First Human Face Allograft: Report at 4 months

  • Jean-Michel Dubernard
  • Bernard Devauchelle


On 27 November 2005, the first face allotransplantation was performed on a patient with an extended soft tissue effect, including the nose, both lips and chin. This type of lesion is very difficult, if not impossible, to reconstruct with satisfactory cosmetic and functional results [1, 2]. Encouraged by the excellent long-term survival and good functional results of human hand allograft [3, 4], we came to the conclusion that composite tissue transplantation was a valuable option in functional facial reconstructive surgery


Radial Forearm Flap Composite Tissue Nasal Vestibule Donor Bone Marrow Cell Hand Transplantation 
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  1. 1.
    Latifoglu O, Ayhan S, Abtay K (1999) Total face reconstruction: skin graft versus skin flap. Plast Reconstruct Surg 103:1076–1078Google Scholar
  2. 2.
    Angrigiani C, Grilli D (1997) Total face reconstruction with one free flap. Plast Reconstruct Surg 99:1566–1571CrossRefGoogle Scholar
  3. 3.
    Dubernard JM, Owen E, Herzberg G et al (1999) Human hand allograft: report on first 6 months. Lancet 353(9161):1315–1320PubMedCrossRefGoogle Scholar
  4. 4.
    Petruzzo P, Revillard JP, Kanitakis J et al (2003) First human double hand transplantation: efficacy of a conventional immunosuppressive protocol. Clin Transplant 17(5):455–460PubMedCrossRefGoogle Scholar
  5. 5.
    Prigozhina T, Slavin S (2004) Transplantation of hematopoietic stem cells for induction of unresponsiveness to organ allografts. Springer, Berlin Heidelberg New YorkGoogle Scholar
  6. 6.
    Monaco AP, Clark AW, Wood ML et al (1976) Possible active enhancement of a human cadaver renal allograft with antilymphocytic serum and donor specific bone marrow: case report of an initial allograft. Surgery 79:384–392PubMedGoogle Scholar
  7. 7.
    Mathew JM, Garcia-Morales RO, Carreno M et al (2003) Immune responses and their regulation by donor bone marrow cells in clinical organ transplantation. Transpl Immunol 11:307–321PubMedCrossRefGoogle Scholar
  8. 8.
    Mathew JM, Garcia-Morales RO, Fuller L et al (2000) Donor bone marrow-derived chimeric cells present in renal transplant recipients infused with donor marrow. I. Potent regulators of recipient antidonor immune responses. Transplantation 70:1675–1682PubMedCrossRefGoogle Scholar
  9. 9.
    Kanitakis J, Petruzzo P, Jullien D et al (2005) Pathological score for evaluation of allograft rejection in human hand composite tissue allotransplantation. Eur J Dermatol 15:235–238PubMedGoogle Scholar
  10. 10.
    Siemionow M, Agaoglu G (2005) Allotransplantation of the face: How close we are? Clin Plast Surg 32:401–409PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Jean-Michel Dubernard
    • 1
  • Bernard Devauchelle
    • 2
  1. 1.Department of TransplantationÉdouard Herriot HospitalLyonFrance
  2. 2.Maxillofacial Unit Nord HospitalCHU AmiensFrance

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