Skip to main content
SpringerLink
Log in

Laryngeal Transplantation

  • Chapter
Hand Transplantation

  • 1344 Accesses

Abstract

Human laryngeal transplantation was first introduced into the literature in the 1960s with experiments using dog models by Boles [1], Ogura et al. [2], and Silver et al [3]. In 1969, Kluyskens and Ringoir attempted to reconstruct the aerodigestive tract after laryngectomy for cancer with a cadaveric transplantation [4]. This transplant was subtotal, preserving recipient perichondrium to revascularize the donor organ without the use of vascular or neural anastomoses. Rapid recurrence of the tumor quashed interest in the procedure for nearly two decades

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Boles R (1966) Surgical replantation of the larynx in dogs: a progress report. Laryngoscope 76:1057–1067

    Article  PubMed  CAS  Google Scholar 

  2. Ogura JH, Kawasaki M, Takenouchi S el at (1966) Replantation and transplantation of the canine larynx. Ann Otol Rhino Laryng 75:295–312

    Google Scholar 

  3. Silver GE, Lieber PS, Som ML (1967) Autologous transplantation of the canine larynx. Arch Otolaryngol 86:95–102

    PubMed  CAS  Google Scholar 

  4. Kluyskens P, Ringoir S (1970) Follow-up of a human larynx transplantation. Laryngoscope 80:1244–1250

    Article  PubMed  CAS  Google Scholar 

  5. Strome M, Wu J, Strome S et al (1994) A comparison of preservation techniques in a vascularized rat laryngeal transplant model. Laryngoscope 104:666–668

    Article  PubMed  CAS  Google Scholar 

  6. Strome S, Brodsky G, Darrell J et al (1992) Histopathologic correlates of acute laryngeal allograft rejection in a rat model. Ann Otol Rhinol Laryngol 101:156–160

    PubMed  CAS  Google Scholar 

  7. Strome M, Strome S, Darrell J et al (1993) The effects of cyclosporin A on transplanted rat allografts. Laryngoscope 103:394–398

    Article  PubMed  CAS  Google Scholar 

  8. Strome M, Stein J, Esclamado R et al (2001) Laryngeal transplantation: a case report with three-year followup. N Engl J Med 344:1676–1679

    Article  PubMed  CAS  Google Scholar 

  9. Lorenz RR, Hicks DM, Sheilds RW et al (2004) Laryngeal nerve function after total laryngeal transplantation. Otolaryngol Head Neck Surg 131:1016–1018

    Article  PubMed  Google Scholar 

  10. Kevorkian KF, Sercarz JA, Ye M et al (1997) Extended canine laryngeal preservation for transplantation. Laryngoscope 107(12 Pt 1):1623–1626

    Article  PubMed  CAS  Google Scholar 

  11. Genden EM, Iskander A, Bromberg JS, Mayer L (2003) The kinetics and pattern of tracheal allograft re-epithelialization. Am J Respir Cell Mol Biol 28:673–681

    Article  PubMed  CAS  Google Scholar 

  12. Birchall MA, Bailey M, Barker EV et al (2002) Model for experimental revascularized laryngeal allotransplantation. Br J Surg 89(11):1470–1475

    Article  PubMed  CAS  Google Scholar 

  13. Lorenz RR, Dan O, Fritz MA, Strome M (2002) The rat laryngeal transplant model: technical advancements and a re-defined rejection grading system. Ann Otol Rhinol Laryngol 111:1120–1127

    PubMed  Google Scholar 

  14. Nelson M, Dan O, Strome M (2003) Evaluation of parathyroid hormone as a functional biological marker of rat laryngeal transplant rejection. Laryngoscope 113:1483–1486

    Article  PubMed  CAS  Google Scholar 

  15. Barthel SW, Dan O, Myles J et al (2001) Effect of in vitro irradiation of donor larynges on cyclosporine requirements and rejection rates in rat laryngeal transplantation. Ann Otol Rhinol Laryngol 110:20–24

    PubMed  CAS  Google Scholar 

  16. Lorenz RR, Dan O, Haug M et al (2003) Immunosuppressive effect of irradiation in the murine laryngeal transplantation model: a controlled trial. Ann Otol Rhinol Laryngol 112:712–715

    PubMed  Google Scholar 

  17. Haug M, Dan O, Wimberley S et al (2003) Cyclosporine dose, serum trough levels, and allograft preservation in a rat model of laryngeal transplantation. Ann Otol Rhinol Laryngol 112:506–510

    PubMed  Google Scholar 

  18. Nelson M, Fritz M, Dan O et al (2003) Tacrolimus and mycophenolate mofetil provide effective immunosuppression in rat laryngeal transplantation. Laryngoscope 113:1308–1313

    Article  PubMed  CAS  Google Scholar 

  19. Akst LM, Siemionow M, Dan O et al (2003) Induction of tolerance in a rat model of laryngeal transplantation. Transplantation 76:1763–1770

    Article  PubMed  CAS  Google Scholar 

  20. Genden EM, Mackinnon SE, Yu S et al (2001) Portal venous ultraviolet B-irradiated donor alloantigen prevents rejection in circumferential rat tracheal allografts. Otolaryngol Head Neck Surg 124:481–488

    Article  PubMed  CAS  Google Scholar 

  21. Gorti GK, Birchall MA, Haverson K et al (1999) A preclinical model for laryngeal transplantation: anatomy and mucosal immunology of the porcine larynx. Transplantation 68:1638–1642

    Article  PubMed  CAS  Google Scholar 

  22. Rees LE, Ayoub O, Haverson K et al (2003) Differential major histocompatibility complex class II locus expression on human laryngeal epithelium. Clin Exp Immunol 134:497–502

    Article  PubMed  CAS  Google Scholar 

  23. Govindaraj S, Gordon R, Genden EM (2004) Effect of fibrin matrix and vascular endothelial growth factor on re-epithelialization of orthotopic murine tracheal transplants. Ann Otol Rhinol Laryngol 113:797–804

    PubMed  Google Scholar 

  24. Stavroulaki P, Birchall M (2001) Comparative study of the laryngeal innervation in humans and animal employed in laryngeal transplantation research. J Laryngol Otol 115:257–266

    Article  PubMed  CAS  Google Scholar 

  25. Blumin JH, Ye M, Berke GS et al (1999) Recovery of laryngeal sensation after superior laryngeal nerve anastomosis. Laryngoscope 109:1637–1641

    Article  PubMed  CAS  Google Scholar 

  26. Peterson KL, Andrews RJ, Sercarz JA et al (1999) Comparison of nerve banking techniques in delayed laryngeal reinnervation. Ann Otol Rhinol Laryngol 108:689–694

    PubMed  CAS  Google Scholar 

  27. Andrews RJ, Berke GS, Blackwell KE et al (2000) Hemilaryngeal transplantation in the canine model: technique and implications. Am J Otolaryngol 21:85–91

    Article  PubMed  CAS  Google Scholar 

  28. Birchall MA, Lorenz RR, Genden EM et al (2005) Laryngeal transplantation in 2005: a review. Am J Transplant [In press]

    Google Scholar 

  29. Penn I (1998) Occurrence of cancers in immunosuppressed organ transplant recipients. Clin Transplant 66:147–158

    Google Scholar 

  30. Sedrani R, Cottens S, Kallen J, Schuler Wl (1998) Chemical modification of rapamycin: The discovery of SDZ RAD. Transplant Proc 30:2192–2194

    Article  PubMed  CAS  Google Scholar 

  31. Boulay A, Zumstein-Mecker S, Stephan C (2004). Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells. Cancer Res 64:252–261

    Article  PubMed  CAS  Google Scholar 

  32. Khariwala SS, Kjaergaard J, Lorenz RR et al (2006) Everolimus (RAD) inhibits in vivo growth of murine squamous cell carcinoma (SCC VII). Laryngoscope [In press]

    Google Scholar 

  33. Monaco AP (2001) Transplantation of the larynx: a case report that speaks for itself. N Engl J Med 344:1712–1714

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Section of Head and Neck Surgery, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, The Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Robert R. Lorenz

  2. The Head and Neck Institute, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, The Cleveland Clinic Foundation, Cleveland, Ohio, USA

    Marshall Strome

Authors
  1. Robert R. Lorenz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Marshall Strome
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Italian Institute of Hand Surgery, Monza,Milan, Italy

    Marco Lanzetta (Director, Adjunct Professor and President) (Director, Adjunct Professor and President)

  2. University of Canberra, Australia

    Marco Lanzetta (Director, Adjunct Professor and President) (Director, Adjunct Professor and President)

  3. International Hand and Composite, Tissue Allograft Society, Australia

    Marco Lanzetta (Director, Adjunct Professor and President) (Director, Adjunct Professor and President)

  4. Department of Transplantation, Édouard Herriot Hospital, Lyon, France

    Jean-Michel Dubernard  & Palmina Petruzzo  & 

  5. Department of Surgery, University of Cagliari, Italy

    Palmina Petruzzo

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer-Verlag Italia

About this chapter

Cite this chapter

Lorenz, R.R., Strome, M. (2007). Laryngeal Transplantation. In: Lanzetta, M., Dubernard, JM., Petruzzo, P. (eds) Hand Transplantation. Springer, Milano. https://doi.org/10.1007/978-88-470-0374-3_50

Download citation

  • DOI: https://doi.org/10.1007/978-88-470-0374-3_50

  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-0373-6

  • Online ISBN: 978-88-470-0374-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation