Induction of High-Level Chimerism in Composite Tissue Transplants

  • Keiichi Muramatsu
  • Kazuteru Doi
  • Hiroshi Tanaka
  • Toshihiko Taguchi


Although the prolonged survival of experimental composite tissue allografts (CTAs) is achievable using immunosuppressive drugs, long-term immunosuppression of CTAs is not acceptable in the clinical setting because of serious side-effects. The development of a model for reliable CTA tolerance induction across a major histocompatibility complex (MHC) mismatch and without the need for long-term immunosuppression is highly desirable.


Chronic GVHD Mixed Chimerism Composite Tissue Graft Acceptance Recipient Bone Marrow 
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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Keiichi Muramatsu
    • 1
  • Kazuteru Doi
    • 2
  • Hiroshi Tanaka
    • 3
  • Toshihiko Taguchi
    • 3
  1. 1.Department of Orthopaedic SurgeryYamaguchi University School of MedicineUbe, YamaguchiJapan
  2. 2.Department of Orthopaedic SurgeryOgori Daiichi General HospitalYamaguchiJapan
  3. 3.Department of Orthopaedic Surgery School of MedicineYamaguchi UniversityYamaguchiJapan

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