Indefinite Survival and Functional Recovery of Limb Allografts in Rodents

  • Takako Kanatani
  • Marco Lanzetta
  • G. Alex Bishop


Over the past decade, the focus of experimental limb transplantation has been to obtain functional recovery and indefinite survival, as reported in previous review articles [1]–[10]. These factors are of paramount importance in non-life-saving procedures, such as hand transplantation, where quality of life is the main indication for reconstruction. There is an additional ethical issue in clinical composite tissue transplantation where continuous and extensive use of powerful immunosuppressive drugs required to obtain long-term limb allograft survival might have serious and possibly fatal consequences. It is necessary to balance the opposing requirements for prolonged graft survival with the need to minimise immunosuppressive drug treatment.


Composite Tissue Prolonged Graft Survival Hand Transplantation Limb Transplantation Donor Cell Chimerism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Takako Kanatani
    • 1
    • 2
  • Marco Lanzetta
    • 3
    • 4
    • 5
    • 6
    • 7
  • G. Alex Bishop
    • 8
  1. 1.The Microsearch Foundation of AustraliaSydneyAustralia
  2. 2.Department of OrthopaedicsRosai HospitalKobeJapan
  3. 3.Italian Institute of Hand SurgeryMonza, MilanItaly
  4. 4.Hand Surgery and Reconstructive Microsurgery UnitSan Gerardo HospitalMonza, MilanItaly
  5. 5.University of Milan-BicoccaMilanItaly
  6. 6.University of CanberraAustralia
  7. 7.International Hand and CompositeTissue Allograft SocietyAustralia
  8. 8.Collaborative Transplant LaboratorySydney UniversitySydneyAustralia

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