Advertisement

Indefinite Survival and Functional Recovery of Limb Allografts in Rodents

  • Takako Kanatani
  • Marco Lanzetta
  • G. Alex Bishop

Abstract

Over the past decade, the focus of experimental limb transplantation has been to obtain functional recovery and indefinite survival, as reported in previous review articles [1]–[10]. These factors are of paramount importance in non-life-saving procedures, such as hand transplantation, where quality of life is the main indication for reconstruction. There is an additional ethical issue in clinical composite tissue transplantation where continuous and extensive use of powerful immunosuppressive drugs required to obtain long-term limb allograft survival might have serious and possibly fatal consequences. It is necessary to balance the opposing requirements for prolonged graft survival with the need to minimise immunosuppressive drug treatment.

Keywords

Composite Tissue Prolonged Graft Survival Hand Transplantation Limb Transplantation Donor Cell Chimerism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hewitt CW, Puglisi RN, Black KS (1995) Current state of composite tissue and limb allotransplantation: Do present data justify clinical application? Transplant Proc 27:1414–1415PubMedGoogle Scholar
  2. 2.
    Llull R, Beko KR, Black KS et al (1992) Composite tissue allotransplantation: Perspectives concerning eventual clinical exploitation. Transplant Rev 6:175–188CrossRefGoogle Scholar
  3. 3.
    Porter BB, Lance EM (1974) Limb and join transplantation, a review of research and clinical experience. Clin Orthop Relat Res 104:249–274PubMedCrossRefGoogle Scholar
  4. 4.
    Petit F, Minns AB, Hettiaratchy SP et al (2003) New trends and future directions of research in hand and composite tissue allotransplantation. J Am Soc Surg Hand 3:170–174CrossRefGoogle Scholar
  5. 5.
    Jensen JN, Mackinon SE (2000) Composite tissue allotransplantation: A comprehensive review of the literature-part I. J Reconstr Microsurg 16:57–68PubMedGoogle Scholar
  6. 6.
    Jensen JN, Mackinon SE (2000) Composite tissue allotransplantation: A comprehensive review of the literature-part II. J Reconstr Microsurg 16:141–157PubMedGoogle Scholar
  7. 7.
    Jensen JN, Mackinon SE (2000) Composite tissue allotransplantation: A comprehensive review of the literature-part III. J Reconstr Microsurg 16:235–251PubMedGoogle Scholar
  8. 8.
    Ayrout C, Lanzetta M, Chunasuwankul R et al (2004) Experimental limb transplantation Part I. Identification of an effective tapered triple combination immunosuppression regime. Transplant Proc 36:669–674PubMedCrossRefGoogle Scholar
  9. 9.
    Lanzetta M, Ayrout C, Gal A et al (2004) Experimental limb transplantation. Part II. Excellent return and indefinite survival after immunosuppression withdrawal. Transplant Proc 36:675–679PubMedCrossRefGoogle Scholar
  10. 10.
    Kanatani T, Lanzetta M, Wright B et al (2004) Experimental limb transplantation Part III: Induction of tolerance in the rigorous strain combination of Brown Norway donor to Lewis recipient. Transplant Proc 36:3276–3282PubMedCrossRefGoogle Scholar
  11. 11.
    Shapiro RI, Cerra FB (1978) A model for reimplantation and transplantation of a complex organ: the rat hind limb. J Surg Res 24:501–506PubMedCrossRefGoogle Scholar
  12. 12.
    Zdichavsky M, Jones JW, Ustuner ET et al (1999) Scoring of skin rejection in swine composite tissue allograft model. J Surg Res 85:1–8PubMedCrossRefGoogle Scholar
  13. 13.
    Bishop GA, Sun J, DeCruz DJ et al (1996) Tolerance to rat liver allografts. III Donor cell migration and tolerance-associated cytokine production in peripheral lymphoid tissues. J Immunol 156:4925–4931PubMedGoogle Scholar
  14. 14.
    Sun J, McCaughan GW, Matsumoto Y et al (1994) Tolerance to rat liver allografts. 1. Differences between tolerance and rejection are more marked in the B cell compared with the T cell or cytokine response. Transplantation 57:1349–1357PubMedCrossRefGoogle Scholar
  15. 15.
    Siemionow MZ, Izycki DM, Zielinski M (2003) Donorspecific tolerance in fully major histocompatibility complex-mismatched limb allograft transplants under an anti-ab T-cell receptor monoclonal antibody and cyclosporine A protocol. Transplantation 12:1662–1668CrossRefGoogle Scholar
  16. 16.
    Starzl TE, Demetris AJ, Murase N et al (1992) Cell migration, chimerism, and graft acceptance. Lancet 339:1579–1582PubMedCrossRefGoogle Scholar
  17. 17.
    Bishop GA, Sun J, Sheil AGR et al (1997) High dose / activation-associated tolerance: a mechanism for allograft tolerance. Transplantation 64:1377–1382PubMedCrossRefGoogle Scholar
  18. 18.
    Hoffman LA, Codner MA, Shuster BA et al (1992) Donor leukocyte migration following extremity transplantation in an experimental model. Plast Reconstr Surg 90:999–1006PubMedCrossRefGoogle Scholar
  19. 19.
    Sharabi Y, Sachs DH (1989) Mixed chimerism and permanent specific transplantation tolerance induced by a nonlethal preparative regimen. J Exp Med 169:493–502PubMedCrossRefGoogle Scholar
  20. 20.
    Cendales LC, Breidenbach WC (2001) Hand transplantation. Hand Clin 17:499–510PubMedGoogle Scholar
  21. 21.
    Udina E, Voda J, Gold BG (2003) Comparative dose-dependance study of FK506 on transected mouse sciatic nerve repaired by allograft or xenograft. J Peripher Nerv Syst 8:145–154PubMedCrossRefGoogle Scholar
  22. 22.
    Gold BG, Katoh K, Strom-Dickerson T (1995) The immunosuppressant FK506 increase the rate of axonal regeneration in rat sciatic nerve. J Neurosci 15:7509–7516PubMedGoogle Scholar
  23. 23.
    Doolabh VB, Machinnon SE (1999) FK506 accelerates functional recovery following nerve grafting in a rat model. Plast Reconstr Surg 103:1928–1936PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Takako Kanatani
    • 1
    • 2
  • Marco Lanzetta
    • 3
    • 4
    • 5
    • 6
    • 7
  • G. Alex Bishop
    • 8
  1. 1.The Microsearch Foundation of AustraliaSydneyAustralia
  2. 2.Department of OrthopaedicsRosai HospitalKobeJapan
  3. 3.Italian Institute of Hand SurgeryMonza, MilanItaly
  4. 4.Hand Surgery and Reconstructive Microsurgery UnitSan Gerardo HospitalMonza, MilanItaly
  5. 5.University of Milan-BicoccaMilanItaly
  6. 6.University of CanberraAustralia
  7. 7.International Hand and CompositeTissue Allograft SocietyAustralia
  8. 8.Collaborative Transplant LaboratorySydney UniversitySydneyAustralia

Personalised recommendations