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Analysis of Motor Unit Reinnervation in Muscles of the Transplanted Hand

  • Marco Pozzo
  • Dario Farina

Abstract

Sensory and motor recovery in hand-transplanted patients is conditioned by nerve regeneration [1]. Whereas functional recovery can be evaluated clinically [2], there is a need for tools allowing direct assessment of muscle control in transplanted muscles at the level of their smallest functional units, the motor units (MUs). These should permit, for example, the ability to determine when MUs are innervated and whether their control strategies and physiological properties are similar to those observed in normally innervated muscles. These issues can be assessed by techniques that allow extraction of the electrical activity from single MUs, such as intramuscular electromyography (EMG). However, noninvasive methods detecting EMG signals on the skin (surface EMG) should be preferred in hand-transplanted subjects to minimise possible damage to the allograft.

Keywords

Motor Unit Conduction Velocity Intrinsic Muscle Innervation Zone Instantaneous Firing Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Owen ER, Dubernard JM, Lanzetta M et al (2001) Peripheral nerve regeneration in human hand transplantation. Transplant Proc 33:1720–1721PubMedCrossRefGoogle Scholar
  2. 2.
    Dubernard JM, Owen E, Herzberg G et al (1999) Human hand allograft: report on first 6 months. Lancet 353:1315–1320PubMedCrossRefGoogle Scholar
  3. 3.
    Lanzetta M, Pozzo M, Bottin A et al (2005) Reinnervation of motor units in intrinsic muscles of a transplanted hand. Neurosci Lett 373(2):138–143PubMedCrossRefGoogle Scholar
  4. 4.
    Lanzetta M, Bottin A, Farina D et al (2002) Non-invasive assessment of reinnervation in the transplanted hand. 4th international symposium on hand transplantation and composite tissue allograft. Varenna, ItalyGoogle Scholar
  5. 5.
    Lanzetta M, Farina D, Pozzo M et al (2004), Motor unit reinnervation and control properties in intrinsic muscles of a transplanted hand. 15th International Society of Electrophysiology and Kinesiology (ISEK) Congress, p 190Google Scholar
  6. 6.
    Basmajian JV, DeLuca CJ (1985) Muscles alive: their functions revealed by electromyography, 2nd Edn. William and Wilkins, BaltimoreGoogle Scholar
  7. 7.
    Andreassen S, Arendt-Nielsen L (1987) Muscle fibre conduction velocity in motor units of the human anterior tibial muscle: a new size principle parameter. J Physiol 391:561–571PubMedGoogle Scholar
  8. 8.
    Masuda T, Miyano H, Sadoyama T (1983) The propagation of motor unit action potential and the location of neuromuscular junction investigated by surface electrode arrays. Electroenceph Clin Neurophysiol 56:507–603CrossRefGoogle Scholar
  9. 9.
    Merletti R, Farina D, Granata A (1999) Non-invasive assessment of motor unit properties with linear electrode arrays. Electroencephalogr Clin Neurophysiol 50:293–300Google Scholar
  10. 10.
    Merletti R, Farina D, Gazzoni M (2003) The linear electrode array: a useful tool with many applications. J Electromyogr Kinesiol 13:37–47PubMedCrossRefGoogle Scholar
  11. 11.
    Pozzo M, Farina D, Merletti R (2003) Electromyography: detection, processing and applications. In: Moore J, Zouridakis G (eds) Handbook of biomedical technology and devices. CRC Press, Boca Raton, pp 4.1–4.66Google Scholar
  12. 12.
    Farina D, Arendt-Nielsen L, Merletti R, Graven-Nielsen T (2002) Assessment of single motor unit conduction velocity during sustained contractions of the tibialis anterior muscle with advanced spike triggered averaging. J Neurosci Methods 30(115):1–12CrossRefGoogle Scholar
  13. 13.
    Bellemare F, Woods JJ, Johansson R, Bigland-Ritchie B (1983) Motor-unit discharge rates in maximal voluntary contractions of three human muscles. J Neurophysiol 50:1380–1392PubMedGoogle Scholar
  14. 14.
    De Luca CJ, Foley PJ, Erim Z (1996) Motor unit control properties in constant-force isometric contractions. J Neurophysiol 76:1503–1516PubMedGoogle Scholar
  15. 15.
    Bawa P, Calancie B (1983) Repetitive doublets in human flexor carpi radialis muscle. J Physiol 339:123–132PubMedGoogle Scholar
  16. 16.
    Partanen VS (1978) Double discharges in neuromuscular diseases. J Neurol Sci 36:377–382PubMedCrossRefGoogle Scholar
  17. 17.
    Nishizono H, Kurata H, Miyashita M et al (1989) Muscle fiber conduction velocity related to stimulation rate. Electroencephalogr Clin Neurophysiol 72:529–534PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Marco Pozzo
    • 1
  • Dario Farina
    • 2
  1. 1.Department of Physiology and Pharmacology Section for Muscle and Exercise PhysiologyKarolinska InstituteStockholmSweden
  2. 2.Center for Sensory-Motor Interaction (SMI) Faculty of Engineering and Science Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

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