From Silent Neuroma to Reactivation of Axonal Growth: How a Peripheral Nerve can Start to Regenerate into a Transplanted Hand?

  • Lars B. Dahlin
  • Göran Lundborg


Neuronal injury with subsequent axonal outgrowth following transection and repair of a nerve trunk puts great demand on the neuron, thereby representing a situation of enormous complexity [1]. Transection of a peripheral nerve trunk has immediate as well as long-term physiological, biochemical and cellular effects on multiple levels of the nervous system, ranging from targets, such as sensory receptors and muscles, in the periphery and all the way up to somatosensory and motor brain cortex [1]–[4]. Such a situation constitutes one of the most challenging and difficult reconstructive problems faced by surgeons. Even a simple cut of a digital nerve represents a major problem for the patient. In spite of immediate repair of the injured nerve, there is usually a suboptimal functional recovery in an adult patient, creating extensive costs for society [5]. This is even worse when large nerve trunks or parts of the brachial plexus are injured.


Dorsal Root Ganglion Schwann Cell Nerve Regeneration Nerve Cell Body Nerve Repair 
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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Lars B. Dahlin
    • 1
  • Göran Lundborg
    • 1
  1. 1.Department of Hand SurgeryMalmö University HospitalMalmöSweden

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