Monitoring Rejection with a Distant Sentinel Skin Graft

  • Marco Lanzetta
  • Luca Rovati


While an internal organ is hidden but works immediately after the transplantation, a hand is fully visible and takes many months to gradually recover sensation and movement [1, 2]. Assessment of viability of transplanted internal organs is usually done by measuring function, either by biochemical evaluations or routine biopsies [3, 4]. In case of a hand, monitoring is largely based on visual inspection [5, 6, 7]. This is a definite advantage compared with internal organs, where an initial rejection may go undetected for some time until the next scheduled biochemical tests or biopsy are carried out. Methods for monitoring rejection in human hand transplantation include visual inspection of skin changes and histological analysis of biopsies. However, repetitive skin biopsies on a relatively small area may pose the problem of leaving multiple visible scars, especially if these procedures must be carried out over a period of many years.


Human Hand Skin Allograft Mixed Leukocyte Reaction Skin Component Hand Transplantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Marco Lanzetta
    • 1
    • 2
    • 3
    • 4
    • 5
  • Luca Rovati
    • 6
  1. 1.Italian Institute of Hand SurgeryMonza,MilanItaly
  2. 2.Hand Surgery and Reconstructive Microsurgery UnitSan Gerardo HospitalMonza,MilanItaly
  3. 3.University of Milan-BicoccaMilanItaly
  4. 4.University of CanberraAustralia
  5. 5.International Hand and CompositeTissue Allograft SocietyAustralia
  6. 6.Plastic Surgery UnitSan Gerardo HospitalMonza, MilanItaly

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