Pharmacological Treatment of Rejection

  • Palmina Petruzzo


At present, rejection of transplanted organs remains the main obstacle in transplantation. It occurs as a result of humoral and cell-mediated responses by the recipient to specific antigens present in donor tissue. These antigens are known as major histocompability complex (MHC) molecules in humans, and this group of molecules is referred to as human leukocyte antigen (HLA) complex molecules. Once graft rejection has begun, it can be classified in hyperacute rejection, acute rejection or chronic rejection [1]. Symptoms of rejection vary depending on the transplanted organ or tissue; usually, the principal sign is improper function of the organ and, rarely, pain or swelling in the location of the transplanted organ. For example, patients who reject a kidney may have oliguria and increase in serum creatinine values, and patients with heart rejection may have symptoms of heart failure.


Human Leukocyte Antigen Acute Rejection Solid Organ Transplantation Chronic Rejection Rejection Episode 
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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Palmina Petruzzo
    • 1
    • 2
  1. 1.Department of TransplantationÉdouard Herriot HospitalLyonFrance
  2. 2.Department of SurgeryUniversity of CagliariItaly

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