Induction and Maintenance Therapy

  • Palmina Petruzzo


The optimal immunosuppressive regimen for initial, maintenance and rejection therapy after hand transplantation has not yet been identified. Composite tissue allograft (CTA), such as hand transplantation, has been performed only experimentally for many years because of the skin’s high degree of immunogenicity. Indeed, it was assumed that the dosage of immunosuppressive drugs required to prevent rejection were too high to be used safely in the clinical setting. Advances in immunopharmacology and the encouraging results achieved in animal models [1]–[3] in this last decade allowed the realization of different human CTAs, including larynx, knee, hand and part of a face. These positive outcomes have been made possible through the use of the latest induction and maintenance regimens.


Acute Rejection Mycophenolate Mofetil Calcineurin Inhibitor Antithymocyte Globulin Hand Transplantation 
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Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Palmina Petruzzo
    • 1
    • 2
  1. 1.Department of TransplantationÉdouard Herriot HospitalLyonFrance
  2. 2.Department of SurgeryUniversity of CagliariItaly

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