Selection of Candidates and Waiting List, Dealing with the Media and the Public, Setting Up a Pilot Study, Clinical Trial Organization, Staff Requisites for Hand Transplantation: The Lyon Experience

  • Jean-Michel Dubernard
  • Xavier Martin
  • Palmina Petruzzo


The hand transplant programme conducted by the Department of Transplantation in Lyon, France, is based on a clinical trial programme approved by the Minister of Health, which allowed only bilateral hand transplantation after evaluation of the protocol by regulatory, scientific and ethical authorities (Comité Consultatif de Protection des Personnes participant à la Recherche Biomédicale Lyon I, Comité Consultatif National d’Éthique, Agence Française de Sécurité Sanitaire des Produits de Santé, Agence de Biomédecine, Comité d’Éthique de l’Université Claude Bernard, Lyon I).


Ethical Climate Solid Organ Transplant Recipient Immunosuppressive Protocol Presume Consent Ethical Research Guideline 
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  1. 1.
    Dubernard JM, Burloux G, Giraux P et al (2002) Three lessons learned from the first double hand transplantation. Bull Acad Natl Med 186(6): 1051–1062PubMedGoogle Scholar
  2. 2.
    Petruzzo P, Revillard JP, Kanitakis J et al (2003) First human double hand transplantation: efficacy of a conventional immunosuppressive protocol. Clin Transplant 17(5):455–460PubMedCrossRefGoogle Scholar
  3. 3.
    Houssin DM, Bouvier d’Yvoire M, Loty B (2001) Composite tissue allografts: the donor side. In: Dubernard JM (ed) Composite tissue allografts. John Libbey Eurotext, ParisGoogle Scholar
  4. 4.
    Moore FD (2000) Ethical problems special to surgery: surgical teaching, surgical innovation, and the surgeon in managed care. Arch Surg 135(1):14–16PubMedCrossRefGoogle Scholar
  5. 5.
    Hausman MR, Masters J, Panozzo A (2003) Hand transplantation: current status. Mt Sinai J Med 70(3):148–152PubMedGoogle Scholar
  6. 6.
    Dubernard JM, Petruzzo P, Lanzetta M et al (2003) Functional results of the first human double-hand transplantation. Ann Surg 238(1):128–136PubMedCrossRefGoogle Scholar
  7. 7.
    Giraux P, Sirigu A, Schneider F, Dubernard JM (2001) Cortical reorganization in motor cortex after graft of both hands. Nat Neurosci 4(7):691–692PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Italia 2007

Authors and Affiliations

  • Jean-Michel Dubernard
    • 1
  • Xavier Martin
    • 1
  • Palmina Petruzzo
    • 1
    • 2
  1. 1.Department of TransplantationÉdouard Herriot HospitalLyonFrance
  2. 2.Department of SurgeryUniversity of CagliariItaly

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