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Optical Coherence Tomography Angiography

  • Masanori Hangai
Chapter

Abstract

Optical coherence tomography (OCT) angiography allows three-dimensional visualization of retinal, choroidal and optic disc vascular networks. This technology depends on the detection of motion-related signals from back-reflected light from the fundus. En face OCT angiography images are similar with those of fluorescein angiography (FA), but has some differences from them, such as an inability to depict blood plasma leakage and pooling as a disadvantage, and selective visualization of microvascular layers as an advantage. The advantage enables visualization of 4 retinal capillary layers, which allows physicians to determine in which layer the capillary pathologies, such as microaneurysms, capillary dilation, and capillary non-perfusion area, are present in diabetic maculopathy and vein occlusive diseases. OCT angiography has been shown to visualize the choroidal neovascularization that is not detected by dye angiography. Other application of OCT angiography is the early diagnosis of glaucoma by the evaluation of optic disc capillary perfusion, and detection of laminar cribrosa capillary defects in glaucoma eyes. Thus, OCT angiography is potentially a powerful tool for improving the diagnosis and management of retinal and macular diseases and glaucoma. Inability to take clear capillary images in a wide area and loss of OCT angiographic signals due to retinal lesions such as retinal hemorrhage, hard exudates, and cystoid spaces, are the current limitation of OCT angiography technology that hamper the use of OCT angiography for daily clinical use. Despite the limitations, OCT angiography will be clinically accepted as a useful additive method to conventional examinations concurrently with the technological advances.

Keywords

Optical Coherence Tomography Retinal Nerve Fiber Layer Fluorescein Angiography Retinal Vein Occlusion Optical Coherence Tomography Imaging 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgement

All of the OCT angiography images used in this chapter were obtained by the prototype OCT angiography software developed for RS-3000 Advance (NIDEK CO., LTD, Gamagori, Japan), and the OCT device was provided by the NIDEK. The author appreciates his collaborators, Mrs. Masaaki Hanebuchi (NIDEK) and Yasuhiro Furuuchi (NIDEK) for their help in the preliminary experiments. The research was partially supported by a Grant-in-Aid for Scientific Research (15K10845) from the Japan Society for the Promotion of Science (JSPS) KAKENHI.

References

  1. Dansingani KK, Balaratnasingam C, Klufas MA et al (2015) Optical coherence tomography angiography of shallow irregular pigment epithelial detachments in pachychoroid spectrum disease. Am J Ophthalmol 160:1243–1254. doi: 10.1016/j.ajo.2015.08.028 CrossRefPubMedGoogle Scholar
  2. Huang D, Jia Y, Rispoli M et al (2015) Optical coherence tomography angiography of time course of choroidal neovascularization in response to anti-angiogenic treatment. Retina 35:2260–2264CrossRefPubMedPubMedCentralGoogle Scholar
  3. Inoue M, Balaratnasingam C, Freund KB (2015) Optical coherence tomography angiography of polypoidal choroidal vasculopathy and polypoidal choroidal neovascularization. Retina 35:2265–2274CrossRefPubMedGoogle Scholar
  4. Ishibazawa A, Nagaoka T, Takahashi A et al (2015) Optical coherence tomography angiography in diabetic retinopathy: a prospective pilot study. Am J Ophthalmol 160:35–44.e1CrossRefPubMedGoogle Scholar
  5. Iwasaki M, Inomata H (1986) Relation between superficial capillaries and foveal structures in the human retina. Invest Ophthalmol Vis Sci 27:1698–1705PubMedGoogle Scholar
  6. Jia Y, Bailey ST, Hwang TS et al (2015) Quantitative optical coherence tomography angiography of vascular abnormalities in the living human eye. Proc Natl Acad Sci U S A 112:E2395–E2402CrossRefPubMedPubMedCentralGoogle Scholar
  7. Jia Y, Bailey ST, Wilson DJ et al (2014a) Quantitative optical coherence tomography angiography of choroidal neovascularization in age-related macular degeneration. Ophthalmology 121:1435–1444CrossRefPubMedPubMedCentralGoogle Scholar
  8. Jia Y, Wei E, Wang X et al (2014b) Optical coherence tomography angiography of optic disc perfusion in glaucoma. Ophthalmology 121:1322–1332CrossRefPubMedPubMedCentralGoogle Scholar
  9. Kiumehr S, Park SC, Syril D et al (2012) In vivo evaluation of focal lamina cribrosa defects in glaucoma. Arch Ophthalmol 130:552–559CrossRefPubMedGoogle Scholar
  10. Liu L, Jia Y, Takusagawa HL et al (2015) Optical coherence tomography angiography of the peripapillary retina in glaucoma. JAMA Ophthalmol 133:1045–1052CrossRefPubMedPubMedCentralGoogle Scholar
  11. Mahmud MS, Cadotte DW, Vuong B et al (2013) Review of speckle and phase variance optical coherence tomography to visualize microvascular networks. J Biomed Opt 18:50901CrossRefPubMedGoogle Scholar
  12. Palejwala NV, Jia Y, Gao SS et al (2015) Detection of nonexudative choroidal neovascularization in age-related macular degeneration with optical coherence tomography angiography. Retina 35:2204–2211CrossRefPubMedPubMedCentralGoogle Scholar
  13. Quaranta-El Maftouhi M, El Maftouhi A, Eandi CM (2015) Chronic central serous chorioretinopathy imaged by optical coherence tomographic angiography. Am J Ophthalmol 160:581–587CrossRefPubMedGoogle Scholar
  14. Snodderly DM, Weinhaus RS (1990) Retinal vasculature of the fovea of the squirrel monkey, Saimiri sciureus: three-dimensional architecture, visual screening, and relationships to the neuronal layers. J Comp Neurol 297:145–163CrossRefPubMedGoogle Scholar
  15. Snodderly DM, Weinhaus RS, Choi JC (1992) Neural-vascular relationships in central retina of macaque monkeys (Macaca fascicularis). J Neurosci 12:1169–1193PubMedGoogle Scholar
  16. Takayama K, Hangai M, Kimura Y et al (2013) Three-dimensional imaging of lamina cribrosa defects in glaucoma using swept-source optical coherence tomography. Invest Ophthalmol Vis Sci 54:4798–4807CrossRefPubMedGoogle Scholar
  17. Tatham AJ, Miki A, Weinreb RN et al (2014) Defects of the lamina cribrosa in eyes with localized retinal nerve fiber layer loss. Ophthalmology 121:110–118CrossRefPubMedGoogle Scholar
  18. Yu S, Pang CE, Gong Y et al (2015) The spectrum of superficial and deep capillary ischemia in retinal artery occlusion. Am J Ophthalmol 159:53–63CrossRefPubMedGoogle Scholar

Copyright information

© Springer India 2017

Authors and Affiliations

  1. 1.Department of OphthalmologySaitama Medical UniversitySaitamaJapan
  2. 2.Department of Ophthalmology, Doheny Eye InstituteUniversity of Southern CaliforniaLos AngelesUSA

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