Advertisement

Intraoperative Spectral Domain Optical Coherence Tomography: Technology, Applications, and Future Perspectives

  • Lyubomyr Lytvynchuk
  • Carl Glittenberg
  • Susanne Binder
Chapter

Abstract

The implementation of spectral domain OCT diagnostic technique into the intraoperative process (iSD-OCT) has drastically improved our understanding of the behavior of ocular tissue during surgical intervention. Being fully integrated into the surgical microscope, iOCT systems allow the surgeon to perform iSD-OCT-guided eye surgery without any interruption of workflow. This chapter reveals the historical aspects of iSD-OCT development, specifics of its exploitation, technical characteristics, as well as its application for use in ophthalmic microsurgery. Multiple ongoing studies are going to determine the feasibility of iSD-OCT in everyday use for certain surgical procedures in the future.

Keywords

Optical Coherence Tomography Macular Hole Internal Limit Membrane Optical Coherence Tomography Imaging Spectral Domain Optical Coherence Tomography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Supplementary material

Video 29.1

(MP4 21989 kb)

324343_1_En_29_MOESM2_ESM.mp4 (391.3 mb)
Video 29.2 (MP4 22875 kb)
324343_1_En_29_MOESM3_ESM.mp4 (202.8 mb)
Video 29.3 (MP4 13822 kb)

References

  1. Aggarwal A, Panat S, Agarwal N, Sowmya G, Alok A, Kishore M (2013) Optical coherence tomography: an emerging perspective. J Dent Sci Oral Rehabil p. 4–7Google Scholar
  2. Binder S, Falkner-Radler C, Hauger C, Matz H, Glittenberg C (2010) Clinical applications of intrasurgical SD-optical coherence tomography. Poster presented at Association for Research in Vision and Ophthalmology, Fort Lauderdale, 2–6 May 2010Google Scholar
  3. Binder S, Falkner-Radler C, Hauger C, Matz H, Glittenberg C (2011) Feasibility of intrasurgical spectral-domain optical coherence tomography. Retina 31:1332–1336CrossRefPubMedGoogle Scholar
  4. Böhringer HJ, Boller D, Leppert J, Knopp U, Lankenau E, Reusche E, Hüttmann G, Giese A (2006) Time-domain and spectral-domain optical coherence tomography in the analysis of brain tumor tissue. Lasers Surg Med 38(6):588–597Google Scholar
  5. Boppart S, Brezinski M, Pitris C, Fujimoto J (1998) Optical coherence tomography for neurosurgical imaging of human intracortical melanoma. Neurosurgery 43:834–841CrossRefPubMedGoogle Scholar
  6. Bouma B, Tearney G (1999) Power-efficient nonreciprocal interferometer and linear scanning fiber-optic catheter for optical coherence tomography. Opt Lett 24:531–533CrossRefPubMedGoogle Scholar
  7. Bourla D, Hubschman J, Culjat M, Tsirbas A, Gupta A, Schwartz S (2008) Feasibility study of intraocular robotic surgery with the da Vinci surgical system. Retina 28:154–158CrossRefPubMedGoogle Scholar
  8. Cabrera M, Maldonado R, Toth C, O’Connell R, Chen B, Chiu S, Farsiu S, Wallace D, Stinnett S, Panayotti G, Swamy G, Freedman S (2012) Subfoveal fluid in healthy full-term newborns observed by handheld spectral-domain optical coherence tomography. Am J Ophthalmol 153:167–175CrossRefPubMedGoogle Scholar
  9. Cabrera M, O’Connell R, Toth C, Maldonado R, Tran-Viet D, Alling-ham M, Chiu S, Farsiu S, MaradiagaPanayotti G, Swamy G, Freed-man S (2013) Macular findings in healthy full-term Hispanic newborns observed by hand-held spectral-domain optical coherence tomography. Ophthalmic Surg Lasers Imaging Retina 44:448–454CrossRefPubMedGoogle Scholar
  10. Chavala S, Farsiu S, Maldonado R, Wallace D, Freedman S, Toth C (2009) In-sights into advanced retinopathy of prematurity using handheld spectral domain optical coherence tomography imaging. Ophthalmology 116:2448–2456CrossRefPubMedPubMedCentralGoogle Scholar
  11. Dayani P, Maldonado R, Farsiu S, Toth C (2009) Intraoperative use of handheld spectral domain optical coherence tomography imaging in macular surgery. Retina 29:1457–1468CrossRefPubMedPubMedCentralGoogle Scholar
  12. De Benito-Llopis L, Mehta J, Angunawela R, Ang M, Tan D (2014) Intraoperative anterior segment optical coherence tomography: a novel assessment tool during deep anterior lamellar keratoplasty. Am J Ophthalmol 157:334–341CrossRefPubMedGoogle Scholar
  13. Ehlers J (2011) Intraoperative OCT and vitreoretinal surgery. Retina Today, Sept, 50-23. http://retinatoday.com/2011/09/intraoperative-oct-and-vitreoretinal-surgery. Accessed 09 July 2015
  14. Ehlers J, Gupta P, Farsiu S, Maldonado R, Kim T, Toth C, Mruthyunjaya P (2010) Evaluation of contrast agents for enhanced visualization in optical coherence tomography. Invest Ophthalmol Vis Sci 51:6614–6619CrossRefPubMedGoogle Scholar
  15. Ehlers J, Kernstine K, Farsiu S, Sarin N, Maldonado R, Toth C (2011a) Analysis of pars plana vitrectomy for optic pit-related maculopathy with intraoperative optical coherence tomography: a possible connection with the vitreous cavity. Arch Ophthalmol 129:1483–1486CrossRefPubMedPubMedCentralGoogle Scholar
  16. Ehlers J, Tao Y, Farsiu S, Maldonado R, Izatt J, Toth C (2011b) Integration of a spectral domain optical coherence tomography system into a surgical microscope for intraoperative imaging. Invest Ophthalmol Vis Sci 6:3153–3159CrossRefGoogle Scholar
  17. Ehlers J, Ohr M, Kaiser P, Srivastava S (2013) Novel microarchitectural dynamics in rhegmatogenous retinal detachments identified with intraoperative optical coherence tomography. Retina 33:1428–1434CrossRefPubMedGoogle Scholar
  18. Ehlers J, Itoh Y, Xu L, Kaiser P, Singh R, Srivastava S (2014a) Factors associated with persistent subfoveal fluid and complete macular hole closure in the PIONEER study. Invest Ophthalmol Vis Sci 56:1141–1146CrossRefPubMedGoogle Scholar
  19. Ehlers J, Kaiser P, Srivastava S (2014b) Intraoperative optical coherence tomography using the RESCAN 700: preliminary results from the DISCOVER study. Br J Ophthalmol 98:1329–1332CrossRefPubMedPubMedCentralGoogle Scholar
  20. Ehlers J, McNutt S, Dar S, Tao Y, Srivastava S (2014c) Visualisation of contrast-enhanced intraoperative optical coherence tomography with indocyanine green. Br J Ophthalmol 98:1588–1591CrossRefPubMedPubMedCentralGoogle Scholar
  21. Ehlers J, Srivastava S, Feiler D, Noonan A, Rollins A, Tao Y (2014d) Integrative advances for OCT-guided ophthalmic surgery and intraoperative OCT: microscope integration, surgical instrumentation, and heads-up display surgeon feedback. PLoS One 9:e105224CrossRefPubMedPubMedCentralGoogle Scholar
  22. Ehlers J, Tam T, Kaiser P, Martin D, Smith G, Srivastava S (2014e) Utility of intraoperative optical coherence tomography during vitrectomy surgery for vitreomacular traction syndrome. Retina 3:1341–1346CrossRefGoogle Scholar
  23. Ehlers J, Tao Y, Srivastava S (2014f) The value of intraoperative optical coherence tomography imaging in vitreoretinal surgery. Curr Opin Ophthalmol 25:221–227CrossRefPubMedPubMedCentralGoogle Scholar
  24. Ehlers J, Xu D, Kaiser P, Singh R, Srivastava S (2014g) Intrasurgical dynamics of macular hole surgery: an assessment of surgery-induced ultrastructural alterations with intraoperative optical coherence tomography. Retina 34:213–221CrossRefPubMedGoogle Scholar
  25. Ehlers J, Petkovsek D, Yuan A, Singh R, Srivastava S (2015) Intrasurgical assessment of subretinal tPA injection for submacular hemorrhage in the PIONEER study utilizing intraoperative OCT. Ophthalmic Surg Lasers Imaging Retina 46:327–332CrossRefPubMedPubMedCentralGoogle Scholar
  26. Falkner-Radler C, Glittenberg C, Gabriel M, Binder S (2015) Intrasurgical microscope-integrated spectral domain optical coherence tomography-assisted membrane peeling. Retina 35(10):2100–2106CrossRefPubMedGoogle Scholar
  27. Feldchtein F, Gelikonov G, Gelikonov V, Kuranov R, Sergeev A, Gladkova N, Shakhov A, Shakhova N, Snopova L, Terent’eva A, Zagainova E, Chumakov Y, Kuznetzova I (1998) Endoscopic applications of optical coherence tomography. Opt Express 3:257–270CrossRefPubMedGoogle Scholar
  28. Fercher A, Drexler W, Hitzenberger C, Lasser T (2003) Optical coherence tomography principles and applications. Rep Prog Phys 66:239–303CrossRefGoogle Scholar
  29. Fujimoto J, Pitris C, Boppart S, Brezinski M (2000) Optical coherence tomography: an emerging technology for biomedical imaging and optical biopsy. Neoplasia 2:9–25CrossRefPubMedPubMedCentralGoogle Scholar
  30. Hahn P (2014) Microscope-integrated OCT provides 3-D images in real-time. Ophthalmology Times. http://ophthalmologytimes.modernmedicine.com/ophthalmologytimes/news/micros cope-integrated-oct-provides-3-d-images-real-time?page=full. Accessed 09 July 2015
  31. Hahn P, Migacz J, O’Connell R, Maldonado R, Izatt J, Toth C (2011) The use of optical coherence tomography in intraoperative ophthalmic imaging. Ophthalmic Surg Lasers Imaging 42:S85–S94CrossRefPubMedPubMedCentralGoogle Scholar
  32. Hahn P, Migacz J, O’Donnell R, Day S, Lee A, Lin P, Vann R, Kuo A, Fekrat S, Mruthyunjaya P, Postel E, Izatt JA, Toth C (2013a) Preclinical evaluation and intraoperative human retinal imaging with a high-resolution microscope integrated spectral domain optical coherence tomography device. Retina 33:1328–1337CrossRefPubMedPubMedCentralGoogle Scholar
  33. Hahn P, Migacz J, O’Connell R, Izatt J, Toth C (2013b) Unprocessed real-time imaging of vitreoretinal surgical maneuvers using a microscope-integrated spectral-domain optical coherence tomography system. Graefes Arch Clin Exp Ophthalmol 251:213–220CrossRefPubMedGoogle Scholar
  34. Hanna N, Saltzman D, Mukai D, Chen Z, Sasse S, Milliken J, Guo S, Jung W, Colt H, Brenner M (2005) Two-dimensional and 3-dimensional optical coherence tomographic imaging of the airway, lung, and pleura. J Thorac Cardiovasc Surg 129:615–622CrossRefPubMedGoogle Scholar
  35. Hayashi A, Yagou T, Nakamura T, Fujita K, Oka M, Fuchizawa C (2011) Intraoperative changes in idiopathic macular holes by spectral-domain optical coherence tomography. Case Rep Ophthalmol 2:149–154CrossRefPubMedPubMedCentralGoogle Scholar
  36. Heindl L, Siebelmann S, Dietlein T, Hüttmann G, Lankenau E, Cursiefen C, Steven P (2015) Future prospects: assessment of intraoperative optical coherence tomography in ab interno glaucoma surgery. Curr Eye Res 40(12):1288–1291CrossRefPubMedGoogle Scholar
  37. Hirnschall N, Amir-Asgari S, Maedel S, Findl O (2013) Predicting the postoperative intraocular lens position using continuous intraoperative optical coherence tomography measurements. Invest Ophthalmol Vis Sci 54:5196–5203CrossRefPubMedGoogle Scholar
  38. Hirnschall N, Norrby S, Weber M, Maedel S, Amir-Asgari S, Findl O (2015) Using continuous intraoperative optical coherence tomography measurements of the aphakic eye for intraocular lens power calculation. Br J Ophthalmol 99:7–10CrossRefPubMedGoogle Scholar
  39. Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA (1991) Optical coherence tomography. Science 22:1178–1181CrossRefGoogle Scholar
  40. Huang Z, Liu X, Song C, Kang J (2012) Motion-compensated hand-held common-path Fourier-domain optical coherence tomography probe for image-guided intervention. Biomed Opt Express 3:3105–3118CrossRefPubMedPubMedCentralGoogle Scholar
  41. Joos K, Shen J (2013) Miniature real-time intraoperative forward-imaging optical coherence tomography probe. Biomed Opt Express 4:1342–1350CrossRefPubMedPubMedCentralGoogle Scholar
  42. Juthani V, Goshe J, Srivastava S, Ehlers J (2014) Association between transient interface fluid on intraoperative OCT and textural interface opacity after DSAEK surgery in the PIONEER study. Cornea 33:887–892CrossRefPubMedPubMedCentralGoogle Scholar
  43. Koprowski R, Wróbel Z (2011) Image processing in optical coherence tomography using Matlab. University of Silesia, KatowiceGoogle Scholar
  44. Kraft M, Glanz H, von Gerlach S, Wisweh H, Lubatschowski H, Arens C (2008) Clinical value of optical coherence tomography in laryngology. Head Neck 30:1628–1635CrossRefPubMedGoogle Scholar
  45. Kumar R, Jariwala M, SA V, Venugopal J, Puttaiah N, Balu R, Rao A, Shetty R (2015) A pilot study on feasibility and effectiveness of intraoperative spectral-domain optical coherence tomography in glaucoma procedures. Transl Vis Sci Technol 4:2CrossRefPubMedPubMedCentralGoogle Scholar
  46. Lee A, Maldonado R, Sarin N, O’Connell R, Wallace D, Freedman S, Cotten M, Toth C (2011) Macular features from spectral-domain optical coherence tomography as an adjunct to indirect ophthalmoscopy in retinopathy of prematurity. Retina 31:1470–1482CrossRefPubMedPubMedCentralGoogle Scholar
  47. Lee L, Srivastava S (2011) Intraoperative spectral-domain optical coherence tomography during complex retinal detachment repair. Ophthalmic Surg Lasers Imaging 42 Online:e71–e74PubMedGoogle Scholar
  48. Li X, Boppart S, Van Dam J, Mashimo H, Mutinga M, Drexler W, Klein M, Pitris C, Krinsky M, Brezinski M, Fujimoto J (2000a) Optical coherence tomography: advanced technology for the endoscopic imaging of Barrett’s esophagus. Endoscopy 32:921–930CrossRefPubMedGoogle Scholar
  49. Li X, Chudoba C, Ko T, Pitris C, Fujimoto J (2000b) Imaging needle for optical coherence tomography. Opt Lett 25:1520–1522CrossRefPubMedGoogle Scholar
  50. Maldonado R, Toth C (2013) Optical coherence tomography in retinopathy of prematurity: looking beyond the vessels. Clin Perinatol 40:271–296CrossRefPubMedPubMedCentralGoogle Scholar
  51. Maldonado R, Izatt J, Sarin N, Wallace D, Freedman S, Cotten C, Toth C (2010) Optimizing hand-held spectral domain optical coherence tomography imaging for neonates, infants, and children. Invest Ophthalmol Vis Sci 51:2678–2685CrossRefPubMedPubMedCentralGoogle Scholar
  52. Maldonado R, O’Connell R, Sarin N, Freedman S, Wallace D, Cotten C, Winter K, Stinnett S, Chiu S, Izatt J, Farsiu S, Toth C (2011) Dynamics of human foveal development after premature birth. Ophthalmology 118:2315–2325CrossRefPubMedPubMedCentralGoogle Scholar
  53. Matz H, Binder S, Glittenberg C, Scharioth G, Findl O, Hirnschall N, Hauger C (2012) Intraoperative applications of OCT in ophthalmic surgery. Biomed Tech (Berl) 57:297Google Scholar
  54. Mehta N (2011) Intraoperative spectral-domain OCT in posterior segment surgery. Retina Today, Sept, 54–56. http://retinatoday.com/2011/09/intraoperative-spectral-domain-oct-in-posterior-segment-surgery. Accessed 09 July 2015
  55. Miller D, Kocaoglu OP, Wang Q, Lee S (2011) Adaptive optics and the eye (super resolution OCT). Eye (Lond) 25:321–330CrossRefGoogle Scholar
  56. Miyakoshi A, Ozaki H, Otsuka M, Hayashi A (2014) Efficacy of intraoperative anterior segment optical coherence tomography during descemet’s stripping automated endothelial keratoplasty. ISRN Ophthalmol 2014:562062CrossRefPubMedPubMedCentralGoogle Scholar
  57. Moreno T, O’Connell R, Chiu S, Farsiu S, Cabrera M, Maldonado R, TranViet D, Freedman S, Wallace D, Toth C (2013) Choroid development and feasibility of choroidal imaging in the preterm and term infants utilizing SD-OCT. Invest Ophthalmol Vis Sci 54:4140–4147CrossRefPubMedPubMedCentralGoogle Scholar
  58. Mujat M, Ferguson R, Iftimia N, Hammer D (2009) Compact adaptive optics line scanning ophthalmoscope. Opt Express 17:10242–10258CrossRefPubMedPubMedCentralGoogle Scholar
  59. Nguyen F, Zysk A, Chaney E, Adie S, Kotynek J, Oliphant U, Bellafiore F, Rowland K, Johnson P, Boppart S (2010) Optical coherence tomography: the intraoperative assessment of lymph nodes in breast cancer. IEEE Eng Med Biol Mag 29:63–70CrossRefPubMedPubMedCentralGoogle Scholar
  60. OKT 1300-E BioMedTech. http://www.biomedtech.biz/products.html. Accessed 09 July 2015
  61. Optovue, iVue® SD-OCT. http://optovue.com/products/ivue/. Accessed 09 July 2015
  62. Puliafito C (2010) Optical coherence tomography: a new tool for intraoperative decision making. Ophthalmic Surg Lasers Imaging 41:6CrossRefPubMedGoogle Scholar
  63. Rahimy E, Wilson J, Tsao T, Schwartz S, Hubschman J (2013) Robotassisted intraocular surgery: development of the IRISS and feasibility studies in an animal model. Eye (Lond) 27:972–978CrossRefGoogle Scholar
  64. Regar E1, Ligthart J, Bruining N, van Soest G (2011) The diagnostic value of intracoronary optical coherence tomography. Herz 36(5):417–429Google Scholar
  65. Rollins A, Ung-Arunyawee R, Chak A, Wong C, Kobayashi K, Sivak M, Izat J (1999) Real-time in vivo imaging of human gastrointestinal ultrastructure by use of endoscopic optical coherence tomography with a novel efficient interferometer design. Opt Lett 24:1358–1360CrossRefPubMedGoogle Scholar
  66. Scott A, Farsiu S, Enyedi L, Wallace D, Toth C (2009) Imaging the infant retina with a hand-held spectral-domain optical coherence tomography device. Am J Ophthalmol 147:364–373CrossRefPubMedGoogle Scholar
  67. Sergeev A, Gelikonov V, Gelikonov G, Feldchtein F, Kuranov R, Gladkova N, Shakhova N, Snopova L, Shakov A, Kuznetzova I, Denisenko A, Pochinko V, Chumakov Y, Streltzova O (1997) In vivo endoscopic OCT imaging of precancer and cancer states of human mucosa. Opt Express 1:432–440CrossRefPubMedGoogle Scholar
  68. Sivak M, Kobayashi K, Izatt JA, Rollins A, Ung-Runyawee R, Chak A, Wong R, Isenberg G, Willis J (2000) High-resolution endoscopic imaging of the GI tract using optical coherence tomography. Gastrointest Endosc 51:474–479CrossRefPubMedGoogle Scholar
  69. Srivastava S (2010) Intraoperative diagnostic techniques. Paper presented at the American Academy of Ophthalmology Retina Subspecialty Day, Chicago, 15–16 Oct 2010Google Scholar
  70. Srivastava S, Ray R, Hubbard B et al (2011) Intraoperative optical coherence tomography. Paper presented at the American Society of Retina Specialists Annual Meeting, Boston, 20–24 Aug 2011Google Scholar
  71. Steven P, Le Blanc C, Velten K, Lankenau E, Krug M, Oelckers S, Heindl L, Gehlsen U, Hüttmann G, Cursiefen C (2013) Optimizing descemet membrane endothelial keratoplasty using intraoperative optical coherence tomography. JAMA Ophthalmol 131:1135–1142CrossRefPubMedGoogle Scholar
  72. Steven P, Le Blanc C, Lankenau E, Krug M, Oelckers S, Heindl LM, Gehlsen U, Huettmann G, Cursiefen C (2014) Optimising deep anterior lamellar keratoplasty (DALK) using intraoperative online optical coherence tomography (iOCT). Br J Ophthalmol 98:900–904CrossRefPubMedPubMedCentralGoogle Scholar
  73. Stolyarenko G, Doroschenko D, Mazurina N, Unes H, Ledeneva M (2011) Surgical isolation of epimacular structures based on OCT en-face. Retina Mapping Annual meeting 2011 of American academy of Ophthalmology, Orlando, 22–25 Oct 2011Google Scholar
  74. Sun CW, Lee SY, Lin KF (2014) Review: optical scanning probe for optical coherence tomography. J Med Biol Eng 34:95–100CrossRefGoogle Scholar
  75. Tao Y, Ehlers J, Toth C, Izatt J (2010) Intraoperative spectral domain optical coherence tomography for vitreoretinal surgery. Opt Lett 35:3315–3317CrossRefPubMedPubMedCentralGoogle Scholar
  76. Tao Y, Srivastava S, Ehlers J (2014) Microscope-integrated intraoperative OCT with electrically tunable focus and heads-up display for imaging of ophthalmic surgical maneuvers. Biomed Opt Express 5:1877–1878CrossRefPubMedPubMedCentralGoogle Scholar
  77. Terashima M, Kaneda H, Suzuki T (2012) The role of optical coherence tomography in coronary intervention. Korean J Intern Med 27:1–12CrossRefPubMedPubMedCentralGoogle Scholar
  78. Toth C, Carrasco-Zevallos O, Keller B, Shen L, Viehland C, Nam D, Hahn P, Kuo A, Izatt J (2015) Surgically integrated swept source optical coherence tomography (SSOCT) to guide vitreoretinal (VR) surgery. Invest Ophthalmol Vis Sci 56:3512Google Scholar
  79. Wykoff C, Berrocal A, Schefler A, Uhlhorn S, Ruggeri M, Hess D (2010) Intraoperative OCT of a full-thickness macular hole before and after internal limiting membrane peeling. Ophthalmic Surg Lasers Imaging 41:7–11CrossRefPubMedGoogle Scholar
  80. Xu D, Dupps W, Srivastava S, Ehlers J (2014) Automated volumetric analysis of interface fluid in descemet stripping automated endothelial keratoplasty using intraoperative optical coherence tomography. Invest Ophthalmol Vis Sci 55:5610–5615CrossRefPubMedPubMedCentralGoogle Scholar
  81. Yaqoob Z, Wu J, Yang C (2005) Spectral domain optical coherence tomography: a better OCT imaging strategy. Biotechniques 39:S6–S13CrossRefPubMedGoogle Scholar
  82. Yaqoob T, Wu J, McDowell E, Heng X, Yang C (2006) Methods and application areas of endoscopic optical coherence tomography. J Biomed Opt 11:063001CrossRefPubMedGoogle Scholar
  83. Zivelonghi C, Ghione M, Kilickesmez K, Loureiro RE, Foin N, Lind-say A, de Silva R, Ribichini F, Vassanelli C, Di Mario C (2014) Intra-coronary optical coherence tomography: a review of clinical applications. J Cardiovasc Med (Hager-stown) 15:543–553CrossRefGoogle Scholar

Copyright information

© Springer India 2017

Authors and Affiliations

  • Lyubomyr Lytvynchuk
    • 1
  • Carl Glittenberg
    • 1
  • Susanne Binder
    • 1
  1. 1.Department of Ophthalmology, Rudolf Foundation ClinicKarl Landsteiner Institute for Retinal Research and ImagingViennaAustria

Personalised recommendations