Ocular Tumors

  • Eduardo B. Rodrigues
  • Ana C. Garcia


Advances in ophthalmic imaging improved diagnosis and management of ocular tumors. Optical coherence tomography (OCT) is a powerful imaging technique that provides cross-sectional imaging of the internal microstructures of biological tissues (Huang et al. 1991). Spectral domain OCT (SD-OCT) has replaced traditional time domain OCT providing high-resolution, high-sensitivity, and high-speed imaging (up to 40,000 scans per second). Such implementations enable noninvasive and noncontact visualization and measurement of the microstructures of the human eye. Recently, software upgrades and new imaging techniques have improved the ability to better evaluate intraocular tumors by allowing longer scan lengths, enhanced depth imaging (EDI), and three-dimensional reconstruction. In ocular oncology, OCT provides tools for diagnosis, treatment planning, and monitoring response.


Optical Coherence Tomography Optical Coherence Tomography Imaging Spectral Domain Optical Coherence Tomography Subretinal Fluid Anterior Segment Optical Coherence Tomography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Andrade RE, Farah ME, Costa RA, Belfort R Jr (2005) Optical coherence tomography findings in macular cavernous haemangioma. Acta Ophthalmol Scand 83:267–269Google Scholar
  2. Arevalo JF, Fernandez CF, Garcia RA (2005) Optical coherence tomography characteristics of choroidal metastasis. Ophthalmology 112:1612–1619CrossRefPubMedGoogle Scholar
  3. Bianciotto C, Shields CL, Guzman JM et al (2011) Assessment of anterior segment tumors with ultrasound biomicroscopy versus anterior segment optical coherence tomography in 200 cases. Ophthalmology 118:1297–1302PubMedGoogle Scholar
  4. Brue C, Saitta A, Nicolai M et al (2013) Epiretinal membrane surgery for combined hamartoma of the retina and retinal pigment epithelium: role of multimodal analysis. Clin Ophthalmol 7:179–184CrossRefPubMedPubMedCentralGoogle Scholar
  5. Demirci H, Cullen A, Sunstrom J (2014) Enhanced Depth Imaging Optical Coherence Tomography of Choroidal Metastasis. Retina 34(7):1354–1359Google Scholar
  6. Espinoza G, Rosenblatt B, Harbour JW (2004) Optical coherence tomography in the evaluation of retinal changes associated with suspicious choroidal melanocytic tumors. Am J Ophthalmol 137:90–95CrossRefPubMedGoogle Scholar
  7. Gallwas JK, Turk L, Stepp H et al (2011) Optical coherence tomography for the diagnosis of cervical intraepithelial neoplasia. Lasers Surg Med 43:206–212CrossRefPubMedGoogle Scholar
  8. Hood CT, Schoenfield LR, Torres V, Singh AD (2011) Iris melanoma. Ophthalmology 118:221–222CrossRefPubMedGoogle Scholar
  9. Horgan N, Shields CL, Mashayekhi A et al (2008) Early macular morphological changes following plaque radiotherapy for uveal melanoma. Retina 28:263–273CrossRefPubMedGoogle Scholar
  10. Huang D, Swanson EA, Lin CP et al (1991) Optical coherence tomography. Science 254:1178–1181CrossRefPubMedPubMedCentralGoogle Scholar
  11. Huot CS, Desai KB, Shah VA (2009) Spectral domain optical coherence tomography of combined hamartoma of the retina and retinal pigment epithelium. Ophthalmic Surg Lasers Imaging 40:322–324CrossRefPubMedGoogle Scholar
  12. Kieval JZ, Karp CL, Abou Shousha M et al (2012) Ultra-high resolution optical coherence tomography for differentiation of ocular surface squamous neoplasia and pterygia. Ophthalmology 119:481–486CrossRefPubMedGoogle Scholar
  13. Kimoto K, Kishi D, Kono H et al (2008) Diagnosis of an isolated retinal astrocytic hamartoma aided by optical coherence tomography. Acta Ophthalmol 86:921–922CrossRefPubMedGoogle Scholar
  14. Muscat S, Parks S, Kemp E, Keating D (2004) Secondary retinal changes associated with choroidal naevi and melanomas documented by optical coherence tomography. Br J Ophthalmol 88:120–124CrossRefPubMedPubMedCentralGoogle Scholar
  15. Pavlin CJ, Vasquez LM, Lee R et al (2009) Anterior segment optical coherence tomography and ultrasound biomicroscopy in the imaging of anterior segment tumors. Am J Ophthalmol 147:214–219CrossRefPubMedGoogle Scholar
  16. Ramasubramanian A, Shields CL, Harmon SA, Shields JA (2010) Autofluorescence of choroidal hemangioma in 34 consecutive eyes. Retina 30:16–22CrossRefPubMedGoogle Scholar
  17. Razzaq L, Emmanouilidis-van SK, Luyten GP, Keizer RJ (2011) Anterior segment imaging for iris melanocytic tumors. Eur J Ophthalmol 21:608–614CrossRefPubMedGoogle Scholar
  18. Saxena S, Sharma B, Bhasker SK (2010) Three-dimensional spectral-domain optical coherence tomography of melanocytoma of the optic nerve head. J Ocul Biol Dis Infor 3:112–116CrossRefPubMedGoogle Scholar
  19. Say EAT, Shah SU, Ferenczy S, Shields C (2011) Optical coherence tomography of retinal and choroidal tumors. J Ophthalmol 2011:385058. doi: 10.1155/2011/385058 PubMedPubMedCentralGoogle Scholar
  20. Sayanagi K, Pelayes DE, Kaiser PK, Singh AD (2011) 3D Spectral domain optical coherence tomography findings in choroidal tumors. Eur J Ophthalmol 21:271–275CrossRefPubMedGoogle Scholar
  21. Schachat AP, Shields JA, Fine SL (1984) Combined hamartomas of the retina and retinal pigment epithelium. Ophthalmology 91:1609–1615CrossRefPubMedGoogle Scholar
  22. Shields CL, Shields JA (2008) Intraocular tumors: an atlas and textbook. Lippincott Williams & Wilkins, PhiladelphiaGoogle Scholar
  23. Shields CL, Materin MA, Shields JA (2005a) Review of optical coherence tomography for intraocular tumors. Curr Opin Ophthalmol 16:141–154CrossRefPubMedGoogle Scholar
  24. Shields CL, Mashayekhi A, Materin MA et al (2005b) Optical coherence tomography of choroidal nevus in 120 patients. Retina 25:243–252CrossRefPubMedGoogle Scholar
  25. Shields CL, Mashayekhi A, Dai VV et al (2005c) Optical coherence tomographic findings of combined hamartoma of the retina and retinal pigment epithelium in 11 patients. Arch Ophthalmol 123:1746–1750CrossRefPubMedGoogle Scholar
  26. Shields CL, Materin MA, Walker C, Marr BP, Shields JA (2006) Photoreceptor loss overlying congenital hypertrophy of the retinal pigment epithelium by optical coherence tomography. Ophthalmology 113:661–665CrossRefPubMedGoogle Scholar
  27. Shields CL, Perez B, Materin MA et al (2007) Optical coherence tomography of choroidal osteoma in 22 cases: evidence for photoreceptor atrophy over the decalcified portion of the tumor. Ophthalmology 114:e53–e58CrossRefPubMedGoogle Scholar
  28. Shields CL, Perez B, Benavides R, Materin MA, Shields JA (2008) Optical coherence tomography of optic disk melanocytoma in 15 cases. Retina 28:441–446CrossRefPubMedGoogle Scholar
  29. Shields CL, Kaliki S, Rojanaporn D et al (2012) Enhanced depth imaging optical coherence tomography of small choroidal melanoma: comparison with choroidal nevus. Arch Ophthalmol 130:850–856CrossRefPubMedGoogle Scholar
  30. Shousha MA, Karp C et al (2013) Diagnosis of ocular surface lesions using ultra–high-resolution optical coherence tomography. Ophthalmology 120:883–891CrossRefPubMedPubMedCentralGoogle Scholar
  31. Singh AD, Belfort RN, Sayanagi K, Kaiser PK (2010) Fourier domain optical coherence tomographic and auto-fluorescence findings in indeterminate choroidal melanocytic lesions. Br J Ophthalmol 94:474–478CrossRefPubMedGoogle Scholar
  32. Spaide RF, Koizumi H, Pozzoni MC (2008) Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 146:496–500CrossRefPubMedGoogle Scholar
  33. Thomas BJ et al (2014) Ultra high-resolution anterior segment optical coherence tomography in the diagnosis and management of ocular surface squamous neoplasia. Ocul Surf 12:46–58CrossRefPubMedGoogle Scholar
  34. Torres VL, Brugnoni N, Kaiser PK, Singh AD (2011) Optical coherence tomography enhanced depth imaging of choroidal tumors. Am J Ophthalmol 151:586–593.e2CrossRefPubMedGoogle Scholar

Copyright information

© Springer India 2017

Authors and Affiliations

  1. 1.Department of OphthalmologyFederal University of São PauloSão PauloBrazil

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