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Central Serous Chorioretinopathy

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Spectral Domain Optical Coherence Tomography in Macular Diseases

Abstract

Central serous chorioretinopathy (CSC) was originally described by Albrecht von Graefe in 1866 as “central recurrent retinitis” (Von Graefe 1866). Since then our understanding of CSC has progressed considerably. Gass in 1967 named the disease as central serous chorioretinopathy and proposed choriocapillaris hyperpermeability as the cause of CSC (Gass 1967). This hypothesis was later supported by studies using indocyanine green angiography (ICGA) which showed multifocal areas of choroidal vascular hyperpermeability in eyes with CSC.

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References

  • Ahn SE, Oh J, Oh JH et al (2013) Three-dimensional configuration of subretinal fluid in central serous chorioretinopathy. Invest Ophthalmol Vis Sci 54:5944–5952

    Article  PubMed  Google Scholar 

  • Bajarborua D (2001) Long-term follow-up of idiopathic central serous chorioretinopathy without laser. Acta Ophthalmol Scand 79:417–421

    Article  Google Scholar 

  • Castro-Correia J, Coutinho MF, Rosas V et al (1992) Long term follow up of central serous retinopathy in 150 patients. Doc Ophthalmol 81:379–386

    Article  CAS  PubMed  Google Scholar 

  • Chan WM, Lam DS, Lai TY et al (2003) Treatment of choroidal neovascularization in central serous chorioretinopathy by photodynamic therapy with verteporfin. Am J Ophthalmol 136:836–845

    Article  CAS  PubMed  Google Scholar 

  • Chan WM, Lai TY, Lai RY et al (2008) Half-dose verteporfin photodynamic therapy for acute central serous chorioretinopathy: one-year results of a randomized controlled trial. Ophthalmology 115:1756–1765

    Article  PubMed  Google Scholar 

  • Cho M, Athanikar A, Paccione J et al (2010) Optical coherence tomography features of acute central serous chorioretinopathy versus neovascular age-related macular degeneration. Br J Ophthalmol 94:597–599

    Article  PubMed  Google Scholar 

  • Ciardella AP, Donsoff IM, Huang SJ et al (2004) Polypoidal choroidal vasculopathy. Surv Ophthalmol 49:25–37

    Article  PubMed  Google Scholar 

  • Cooper BA, Thomas MA (2000) Submacular surgery to remove choroidal neovascularization associated with central serous chorioretinopathy. Am J Ophthalmol 130:187–191

    Article  CAS  PubMed  Google Scholar 

  • Ellabban AA, Tsujikawa A, Ooto S et al (2013) Focal choroidal excavation in eyes with central serous chorioretinopathy. Am J Ophthalmol 56:673–683

    Article  Google Scholar 

  • Fawzi AA, Holland GN, Kreiger AE et al (2006) Central serous chorioretinopathy after solid organ transplantation. Ophthalmology 113:805–813

    Article  PubMed  Google Scholar 

  • Ferrara D, Mohler KJ, Waheed N et al (2014) En-face enhanced-depth swept-source optical coherence tomography features of chronic central serous chorioretinopathy. Ophthalmology 121:719–726

    Article  PubMed  Google Scholar 

  • Fong AH, Li KK, Wong D (2011) Choroidal evaluation using enhanced depth imaging spectral-domain optical coherence tomography in Vogt-Koyanagi-Harada disease. Retina 31:502–509

    Article  PubMed  Google Scholar 

  • Fujimoto H, Gomi F, Wakabayashi T et al (2008) Morphologic changes in acute central serous chorioretinopathy evaluated by Fourier-domain optical coherence tomography. Ophthalmology 115:1494–1500

    Article  PubMed  Google Scholar 

  • Fung AT, Yannuzzi LA, Freund KB (2012) Type 1 (sub-retinal pigment epithelial) neovascularization in central serous chorioretinopathy masquerading as neovascular age-related macular degeneration. Retina 32:1829–1837

    Article  PubMed  Google Scholar 

  • Gäckle HC, Lang GE, Freissler KA et al (1998a) Central serous chorioretinopathy. Clinical, fluorescein angiography and demographic aspects. Ophthalmologe 95:529–533

    Article  PubMed  Google Scholar 

  • Gäckle HC, Lang GE, Freidler KA et al (1998b) Clinical fluorescein angiographic and demographic aspects in central serous chorioretinopathy. Ophthalmologe 95:529–533

    Article  PubMed  Google Scholar 

  • Gass JDM (1967) Pathogenesis of disciform detachment of the neuroepithelium: II. Idiopathic central serous choroidopathy. Am J Ophthalmol 63:587–615

    Google Scholar 

  • Gass JDM (1973) Bullous retinal detachment. An unusual manifestation of idiopathic central serous choroidopathy. Am J Ophthalmol 75:810–882

    Article  CAS  PubMed  Google Scholar 

  • Gass JDM (1991) Central serous chorioretinopathy and white subretinal exudation during pregnancy. Arch Ophthalmol 109:677–681

    Article  CAS  PubMed  Google Scholar 

  • Gass JDM (1992) Bullous retinal detachment and multiple retinal pigment epithelium detachments in patients receiving haemodialysis. Graefes Arch ClinExpOphthalmol 230:454–458

    Article  CAS  Google Scholar 

  • Gass JDM, Little H (1995) Bilateral bullous exudative retinal detachment complicating idiopathic central serous chorioretinopathy during systemic corticosteroid therapy. Ophthalmology 102:737–747

    Article  CAS  PubMed  Google Scholar 

  • Gupta V, Gupta A, Gupta P et al (2009) Spectral-domain cirrus optical coherence tomography of choroidal striations seen in the acute stage of Vogt-Koyanagi-Harada disease. Am J Ophthalmol 147:148–153

    Article  PubMed  Google Scholar 

  • Gupta V, Gupta P, Dogra MR et al (2010a) Spontaneous closure of retinal pigment epithelium microrip in the natural course of central serous chorioretinopathy. Eye (Lond) 24:595–599

    Article  CAS  Google Scholar 

  • Gupta P, Gupta V, Dogra MR et al (2010b) Morphological changes in the retinal pigment epithelium on spectral-domain OCT in the unaffected eyes with idiopathic central serous chorioretinopathy. Int Ophthalmol 30:175–181

    Article  PubMed  Google Scholar 

  • Hooymans JM (1998) Fibrotic scar formation in central serous chorioretinopathy developed during systemic treatment with corticosteroids. Graefes Arch Clin Exp Ophthalmol 236:876–879

    Article  CAS  PubMed  Google Scholar 

  • Iida T, Spaide RF, Haas A et al (2002) Leopard-spot pattern of yellowish subretinal deposits in central serous chorioretinopathy. Arch Ophthalmol 120:37–42

    Article  PubMed  Google Scholar 

  • Imamura Y, Fujiwara T, Margolis R et al (2009) Enhanced depth imaging optical coherence tomography of the choroid in central serous chorioretinopathy. Retina 29:1469–1473

    Article  PubMed  Google Scholar 

  • Imamura Y, Fujiwara T, Spaide RF (2011) Fundus autofluorescence and visual acuity in central serous chorioretinopathy. Ophthalmology 118:700–705

    Article  PubMed  Google Scholar 

  • Ishihara K, Hangai M, Kita M et al (2009) Acute Vogt-Koyanagi-Harada disease in enhanced spectral-domain optical coherence tomography. Ophthalmology 116:1799–1807

    Article  PubMed  Google Scholar 

  • Kim HC, Cho WB, Chung H (2012) Morphologic changes in acute central serous chorioretinopathy using spectral domain optical coherence tomography. Korean J Ophthalmol 26:347–354

    Article  PubMed  PubMed Central  Google Scholar 

  • Kim SK, Kim SW, Oh J et al (2013) Near-infrared and short-wavelength autofluorescence in resolved central serous chorioretinopathy: association with outer retinal layer abnormalities. Am J Ophthalmol 156:157–164

    Article  PubMed  Google Scholar 

  • Kitaya N, Nagaoka T, Hikichi T et al (2003) Features of abnormal choroidal circulation in central serous chorioretinopathy. Br J Ophthalmol 87:709–712

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Koizumi H, Yamagishi T, Yamazaki T et al (2013) Relationship between clinical characteristics of polypoidal choroidal vasculopathy and choroidal vascular hyperpermeability. Am J Ophthalmol 155:305–313

    Article  PubMed  Google Scholar 

  • Konstantinidis L, Mantel I, Zografos L et al (2010) Intravitreal ranibizumab in the treatment of choroidal neovascularization associated with idiopathic central serous chorioretinopathy. Eur J Ophthalmol 20:955–958

    PubMed  Google Scholar 

  • Lanzetta P, Furlan F, Morgante L et al (2008) Nonvisible subthreshold micropulse diode laser (810 nm) treatment of central serous chorioretinopathy. A pilot study. Eur J Ophthalmol 18:934–940

    CAS  PubMed  Google Scholar 

  • Lee JH, Lee WK (2014) Choroidal neovascularization associated with focal choroidal excavation. Am J Ophthalmol 157:710–718

    Article  PubMed  Google Scholar 

  • Lee SB, Kim JY, Kim WJ et al (2013) Bilateral central serous chorioretinopathy with retinal pigment epithelium tears following epidural steroid injection. In J Ophthalmol 61:514–515

    Google Scholar 

  • Lee CS, Woo SJ, Kim YK et al (2014) Clinical and spectral-domain optical coherence tomography findings in patients with focal choroidal excavation. Ophthalmology 121:1029–1035

    Article  PubMed  Google Scholar 

  • Lehmann M, Wolff B, Vasseur V et al (2013) Retinal and choroidal changes observed with ‘En-face’ enhanced-depth imaging OCT in central serous chorioretinopathy. Br J Ophthalmol 97:1181–1186

    Article  PubMed  Google Scholar 

  • Levine R, Brucker AJ, Robinson F (1989) Long-term follow-up of idiopathic central serous chorioretinopathy by fluorescein angiography. Ophthalmology 96:854–859

    Article  CAS  PubMed  Google Scholar 

  • Liegl R, Ulbig MW (2014) Central serous chorioretinopathy. Ophthalmologica 232:65–76, Epub ahead of print

    Article  PubMed  Google Scholar 

  • Lumbroso B, Savastano MC, Rispoli M et al (2011) Morphologic differences, according to etiology, in pigment epithelial detachments by means of en-face optical coherence tomography. Retina 31:553–558

    Article  PubMed  Google Scholar 

  • Luk FO, Fok AC, Lee A et al (2015) Focal choroidal excavation in patients with central serous chorioretinopathy. Eye (Lond) 29:453–459

    Google Scholar 

  • Maruko I, Iida T, Sugano Y et al (2010) Subfoveal choroidal thickness after treatment of central serous chorioretinopathy. Ophthalmology 117:1792–1799

    Article  PubMed  Google Scholar 

  • Maruko I, Iida T, Ojima A et al (2011a) Subretinal dot-like precipitates and yellow material in central serous chorioretinopathy. Retina 31:759–765

    Article  PubMed  Google Scholar 

  • Maruko I, Tomohiro I, Sugano Y et al (2011b) Subfoveal choroidal thickness after treatment of Vogt-Koyanagi-Harada disease. Retina 31:510–517

    Article  PubMed  Google Scholar 

  • Matsumoto H, Sato T, Kishi S (2009) Outer nuclear layer thickness at the fovea determines visual outcomes in resolved central serous chorioretinopathy. Am J Ophthalmol 148:105–110

    Article  PubMed  Google Scholar 

  • Matsunaga H, Nangoh K, Uyama M et al (1995) Occurrence of choroidal neovascularization following photocoagulation treatment for central serous retinopathy. Nippon GankaGakkaiZasshi 99:460–468

    CAS  Google Scholar 

  • Miki A, Kondo N, Yanagisawa S et al (2014) Common variants in the complement factor h gene confer genetic susceptibility to central serous chorioretinopathy. Ophthalmology 121:1067–1072

    Article  PubMed  Google Scholar 

  • Montero JA, Ruiz-Moreno JM, Fernandez-Muñoz M (2011) Intravitreal bevacizumab to treat choroidal neovascularization following photodynamic therapy in central serous choroidopathy. Eur J Ophthalmol 21:503–505

    Article  PubMed  Google Scholar 

  • Mrejen S, Spaide RF (2013) Optical coherence tomography: imaging of the choroid and beyond. Surv Ophthalmol 58:387–429

    Article  PubMed  Google Scholar 

  • Nair U, Ganekal S, Soman M et al (2012) Correlation of spectral domain optical coherence tomography findings in acute central serous chorioretinopathy with visual acuity. Clin Ophthalmol 6:1949–1954

    PubMed  PubMed Central  Google Scholar 

  • Nazari H, Hariri A, Hu Z et al (2014) Choroidal atrophy and loss of choriocapillaris in convalescent stage of Vogt-Koyanagi-Harada disease: in vivo documentation. J Ophthalmic Inflamm Infect 4:9

    Article  PubMed  PubMed Central  Google Scholar 

  • Nicholson B, Noble J, Forooghian F et al (2013) Central serous chorioretinopathy: update on pathophysiology and treatment. Surv Ophthalmol 58:103–126

    Article  PubMed  PubMed Central  Google Scholar 

  • Nomura Y, Obata R, Yanagi Y (2012) Intravitreal bevacizumab for iatrogenic choroidal neovascularization due to laser photocoagulation in central serous chorioretinopathy. Jpn J Ophthalmol 56:245–249

    Article  CAS  PubMed  Google Scholar 

  • Odrobina D, Laudańska-Olszewska I, Gozdek P et al (2013) Morphologic changes in the foveal photoreceptor layer before and after laser treatment in acute and chronic central serous chorioretinopathy documented in spectral-domain optical coherence tomography. J Ophthalmol 2013:361513

    PubMed  PubMed Central  Google Scholar 

  • Ojima Y, Hangai M, Sasahara M et al (2007) Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography. Ophthalmology 114:2197–2207

    Article  PubMed  Google Scholar 

  • Ooto S, Tsujikawa A, Mori S et al (2010) Thickness of photoreceptor layers in polypoidal choroidal vasculopathy and central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 248:1077–1086

    Article  PubMed  Google Scholar 

  • Ooto S, Tsujikawa A, Mori S et al (2011) Retinal microstructural abnormalities in central serous chorioretinopathy and polypoidal choroidal vasculopathy. Retina 31:527–534

    Article  PubMed  Google Scholar 

  • Otsuka S, Ohnba N, Nakao K (2002) A long-term follow-up study of severe variant of central serous chorioretinopathy. Retina 22:25–32

    Article  PubMed  Google Scholar 

  • Ozdemir O, Erol MK (2014) Morphologic changes and visual outcomes in resolved central serous chorioretinopathy treated with ranibizumab. Cutan Ocul Toxicol 33(2):122–126, Epub ahead of print

    Article  PubMed  Google Scholar 

  • Polak BCP, Baarsma GS, Snyers B (1995) Diffuse retinal pigment epitheliopathy complicating systemic corticosteroid treatment. Br J Ophthalmol 79:922–925

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Pryds A, Larsen M (2013) Foveal function and thickness after verteporfin photodynamic therapy in central serous chorioretinopathy with hyperautofluorescent subretinal deposits. Retina 33:128–135

    Article  CAS  PubMed  Google Scholar 

  • Quin G, Liew G, Ho IV et al (2013) Diagnosis and interventions for central serous chorioretinopathy: review and update. Clin Exp Ophthalmol 41:187–200

    Article  PubMed  Google Scholar 

  • Reibaldi M, Cardascia N, Longo A et al (2010) Standard-fluence versus low-fluence photodynamic therapy in chronic central serous chorioretinopathy: a nonrandomized clinical trial. Am J Ophthalmol 149:307–315

    Article  PubMed  Google Scholar 

  • Rogers AH, Martidis A, Greenberg PB et al (2002) Optical coherence tomography findings following photodynamic therapy of choroidal neovascularization. Am J Ophthalmol 134:566–576

    Article  PubMed  Google Scholar 

  • Roisman L, Magalhães FP, Lavinsky D et al (2013) Micropulse diode laser treatment for chronic central serous chorioretinopathy: a randomized pilot trial. Ophthalmic Surg Lasers Imaging Retina 44:465–470

    Article  PubMed  Google Scholar 

  • Ross A, Ross AH, Mohamed Q (2011) Review and update of central serous chorioretinopathy. Curr Opin Ophthalmol 22:166–173

    Article  PubMed  Google Scholar 

  • Sahu DK, Namperumalsamy P, Hilton GF et al (2000) Bullous variant of idiopathic central serous chorioretinopathy. Br J Ophthalmol 84:485–492

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Sakata VM, da Silva FT, Hirata CE et al (2014) Choroidal bulging in patients with Vogt-Koyanagi-Harada disease in the non-acute uveitic stage. J Ophthalmic Inflamm Infect 4:6

    Article  PubMed  PubMed Central  Google Scholar 

  • Sasahara M, Tsujikawa A, Musashi K et al (2006) Polypoidal choroidal vasculopathy with choroidal vascular hyperpermeability. Am J Ophthalmol 142:601–607

    Article  PubMed  Google Scholar 

  • Sato T, Kishi S, Watanabe G, Matsumoto H, Mukai R (2007) Tomographic features of branching vascular networks in polypoidal choroidal vasculopathy. Retina 27:589–594

    Article  PubMed  Google Scholar 

  • Schatz H, McDonald HR, Johnson RN et al (1995) Subretinal fibrosis in central serous chorioretinopathy. Ophthalmology 102:1077–1088

    Article  CAS  PubMed  Google Scholar 

  • Sekiryu T, Iida T, Maruko I et al (2010) Infrared fundus autofluorescence and central serous chorioretinopathy. Invest Ophthalmol Vis Sci 51:4956–4962

    Article  PubMed  Google Scholar 

  • Shinojima A, Hirose T, Mori R et al (2010) Morphologic findings in acute central serous chorioretinopathy using spectral domain-optical coherence tomography with simultaneous angiography. Retina 30:193–202

    Article  PubMed  Google Scholar 

  • Song IS, Shin YU, Lee BR (2012) Time-periodic characteristics in the morphology of idiopathic central serous chorioretinopathy evaluated by volume scan using spectral-domain optical coherence tomography. Am J Ophthalmol 154:366–375

    Article  PubMed  Google Scholar 

  • Spaide RF, Koizumi H, Pozzoni MC (2008) Enhanced depth imaging spectral-domain optical coherence tomography. Am J Ophthalmol 146:496–500

    Article  PubMed  Google Scholar 

  • Suzuki M, Gomi F, Hara C et al (2014) Characteristics of central serous chorioretinopathy complicated by focal choroidal excavation. Retina 4(6):1216–1222 [Epub ahead of print]

    Article  Google Scholar 

  • Vasconcelos-Santos DV, Sohn EH, Sadda S et al (2010) Retinal pigment epithelial changes in chronic Vogt-Koyanagi-Harada disease: fundus autofluorescence and spectral domain-optical coherence tomography findings. Retina 30:33–41

    Article  PubMed  PubMed Central  Google Scholar 

  • Von Graefe A (1866) Ueber central recidivierende retinitis. Graefes Arch Clin Exp Ophthalmol 12:211–215

    Article  Google Scholar 

  • Wang M, Sander B, la Cour M et al (2005) Clinical characteristics of subretinal deposits in central serous chorioretinopathy. Acta Ophthalmol Scand 83:691–696

    Article  PubMed  Google Scholar 

  • Wojtkowski M, Srinivasan V, Fujimoto JG et al (2005) Three-dimensional retinal imaging with high speed ultrahigh resolution optical coherence tomography. Ophthalmology 112:1734–1746

    Article  PubMed  PubMed Central  Google Scholar 

  • Yalcinbayir O, Gelisken O, Akova-Budak B et al (2014) Correlation of spectral domain optical coherence tomography findings and visual acuity in central serous chorioretinopathy. Retina 34:705–712

    Article  PubMed  Google Scholar 

  • Yang L, Jonas JB, Wei W et al (2013) Optical coherence tomography assisted enhanced depth imaging of central serous chorioretinopathy. Invest Ophthalmol Vis Sci 54:4659–4665

    Article  PubMed  Google Scholar 

  • Yannuzzi LA, Shakin JL, Fisher YL et al (1984) Peripheral retinal detachments and retinal pigment epithelial atrophic tracts secondary to central serous pigment epitheliopathy. Ophthalmology 91:1554–1572

    Article  CAS  PubMed  Google Scholar 

  • Yannuzzi LA, Slakter JS, Gross NE et al (2012) Indocyanine green angiography-guided photodynamic therapy for treatment of chronic central serous chorioretinopathy: a pilot study. Retina 32(Suppl 1):288–298

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China

    Angie H. C. Fong FRCS & Timothy Y. Y. Lai FRCS, FRCOphth

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  1. Angie H. C. Fong FRCS
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  2. Timothy Y. Y. Lai FRCS, FRCOphth
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Correspondence to Timothy Y. Y. Lai FRCS, FRCOphth .

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Editors and Affiliations

  1. Pallas Clinic, Aarau, Switzerland

    Carsten H. Meyer

  2. Department of Ophthalmology, King George's Medical University, Lucknow, India

    Sandeep Saxena

  3. Doheny Eye Institute, Los Angeles, USA

    SriniVas R Sadda

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Fong, A.H.C., Lai, T.Y.Y. (2017). Central Serous Chorioretinopathy. In: Meyer, C., Saxena, S., Sadda, S. (eds) Spectral Domain Optical Coherence Tomography in Macular Diseases. Springer, New Delhi. https://doi.org/10.1007/978-81-322-3610-8_18

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