Abstract
The enormous burden of infectious as well as noninfectious diseases makes biomarker discovery-based research an imperative in the developing world. The extent of diversity and heterogeneity in the type of diseases that plague the low- and middle-income group nations often show a stark difference with the diseases that affect the developed countries. In order to enable global efforts to combat any given disease, it is important for researchers to have a large number of reliable biospecimens on which they could validate their findings. Inappropriate representation of samples at primary stages of research has sometimes been attributed to researchers not being able to find gold-standard biomarkers. To capture the disease heterogeneity in the subjects ranging from genetic and ethnic diversity to the underlying pathogenesis, it is important to create a resource which could facilitate the availability of biospecimens from a large cohort of subjects along with their clinical annotation, which can be studied by researchers for reliable biomarker discovery. Moreover, biorepositories are also necessary resources for facilitating validation-based studies following the discovery phase. This chapter summarizes the pressing need for well-planned and managed biorepositories as one of the primary steps to facilitate reliable biomarker discovery in the developing world.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Boutayeb A, Boutayeb S (2005) The burden of non communicable diseases in developing countries. Int J Equity Health 4:2. doi:10.1186/1475-9276-4-2
Cheng S, Larson MG, McCabe EL et al (2015) Distinct metabolomic signatures are associated with longevity in humans. Nat Commun. doi:10.1038/ncomms7791
Collins FS, Varmus H (2015) A new initiative on precision medicine. N Engl J Med 372:793–795. doi:10.1056/NEJMp1500523
GBI Research (2012) Biobanks—2012 year book [online], http://www.gbiresearch.com/Report.aspx?ID=Biobanks-2012-Year-Book2012
Gupta S, Venkatesh A, Ray S, Srivastava S (2014) Challenges and prospects for biomarker research: a current perspective from the developing world. Biochim Biophys Acta (5):899–908. doi:10.1016/j.bbapap.2013.12.020
Hanash SM (2011) Why have protein biomarkers not reached the clinic? Genome Med 3(10):66. doi:10.1186/gm282
Harris JR, Burton P, Knoppers BM et al (2012) Toward a roadmap in global biobanking for health. Eur J Hum Genet EJHG 20:1105–1111. doi:10.1038/ejhg.2012.96
Kim MS, Pinto SM, Getnet D et al (2014) A draft map of the human proteome. Nature 509:575–581. doi:10.1038/nature13302
Montague E, Janko E, Stanberry L et al (2015) Beyond protein expression, MOPED goes multi-omics. Nucleic Acids Res. doi:10.1093/nar/gku1175
Otlowski M, Nicol D, Stranger M (2010) Biobanks information paper. J Law Inform Sci 5:20(1)97
Ray S, Moiyadi A, Srivastava S (2013) Biorepositories for cancer research in developing countries. Nat Rev Clin Oncol 10(8):434–436. doi:10.1038/nrclinonc.2013.119
Roychowdhury S, Iyer MK, Robinson DR et al (2011) Personalized oncology through integrative high-throughput sequencing: a pilot study. Sci Transl Med 3:111ra121. doi:10.1126/scitranslmed.3003161
Sgaier SK, Jha P, Mony P, Kurpad A, Lakshmi V, Kumar R, Ganguly NK (2007) Biobanks in developing countries: needs and feasibility. Sci N Y Wash 318(5853):1074
Shi Y, Au JS-K, Thongprasert S et al (2014) A prospective, molecular epidemiology study of EGFR mutations in Asian patients with advanced non–small-cell lung cancer of adenocarcinoma histology (PIONEER). J Thorac Oncol 9:154–162. doi:10.1097/JTO.0000000000000033
Specimen Central (2016) [Online], http://specimencentral.com/biobank-directory/
Stegemann C, Pechlaner R, Willeit P et al (2014) Lipidomics profiling and risk of cardiovascular disease in the prospective population-based Bruneck study. Circulation 129:1821–1831. doi:10.1161/CIRCULATIONAHA.113.002500
Uhlén M, Fagerberg L, Hallström BM et al (2015) Tissue-based map of the human proteome. Science 347:1260419. doi:10.1126/science.1260419
Venter JC, Adams MD, Myers EW et al (2001) The sequence of the human genome. Science 291:1304–1351. doi:10.1126/science.1058040
Wilhelm M, Schlegl J, Hahne H et al (2014) Mass-spectrometry-based draft of the human proteome. Nature 509:582–587. doi:10.1038/nature13319
World Health Organization factsheet (2014) [Online], http://www.who.int/mediacentre/factsheets/fs310/en/
World Health Organization factsheet on the World Malaria Report (2013) [Online], http://www.who.int/malaria/media/world_malaria_report_2013/en/
UNAIDS factsheet (2014) [Online], http://www.unaids.org/en/resources/campaigns/2014/2014gapreport/factsheet
Zika E, Paci D, Bäumen TS, Braun A et al (2010) Biobanks in Europe: prospects for harmonisation and networking, JRC scientific and technical reports, Publications Office of the European Union. ISSN 1018-5593. doi: 10.2791/41701
Acknowledgements
This work has been supported by the Department of Biotechnology, Government of India, Project No. BT/PR8698/MED/29/750/2013.Competing Interests The authors declare no competing interests.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer India
About this chapter
Cite this chapter
Gupta, S. et al. (2016). Exigencies of Biomarker Research in the Developing World: A Focus on the Dearth of Biobanking Resources. In: Srivastava, S. (eds) Biomarker Discovery in the Developing World: Dissecting the Pipeline for Meeting the Challenges. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2837-0_1
Download citation
DOI: https://doi.org/10.1007/978-81-322-2837-0_1
Published:
Publisher Name: Springer, New Delhi
Print ISBN: 978-81-322-2835-6
Online ISBN: 978-81-322-2837-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)