Skip to main content

Graft Thickness and Its Relationship to Visual Outcome in Endothelial Keratoplasty

  • Chapter
  • First Online:
Mastering Endothelial Keratoplasty

Abstract

Descemet’s stripping automated endothelial keratoplasty (DSAEK) is the most popular technique to replace diseased endothelium [1]. In this procedure, donor Descemet’s membrane and endothelium along with a thin layer of deep stroma is juxtaposed to host cornea that is stripped of Descemet’s membrane. Visual outcome is quite good, but not all patients can achieve 20/20 BSCVA. A stromal interface is created between recipient stroma and donor tissue. Some believe this interface is responsible for suboptimal visual results obtained in a percentage of patients undergoing this type of surgery (Fig. 12.1) [2–4].

Financial Interest

Dhaliwal: Novabay (medical advisory board); Abbott Medical Optics (research support, trainer for Visx and Intralase lasers); Avedro (research support)

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Anshu A, Price MO, Tan DT, Price Jr FW. Endothelial keratoplasty: a revolution in evolution. Surv Ophthalmol. 2012;57(3):236–52.

    Article  PubMed  Google Scholar 

  2. Neff KD, Biber JM, Holland EJ. Comparison of central corneal graft thickness to visual acuity outcomes in endothelial keratoplasty. Cornea. 2011;30(4):388–91.

    Article  PubMed  Google Scholar 

  3. Patel SV, Baratz KH, Hodge DO, Maguire LJ, McLaren JW. The effect of corneal light scatter on vision after Descemet stripping with endothelial keratoplasty. Arch Ophthalmol. 2009;127(2):153–60.

    Article  PubMed  Google Scholar 

  4. Dupps Jr WJ, Qian Y, Meisler DM. Multivariate model of refractive shift in Descemet-stripping automated endothelial keratoplasty. J Cataract Refract Surg. 2008;34(4):578–84.

    Article  PubMed  PubMed Central  Google Scholar 

  5. Busin M, Albé E. Does thickness matter: ultrathin Descemet stripping automated endothelial keratoplasty. Curr Opin Ophthalmol. 2014;25(4):312–8.

    Article  PubMed  Google Scholar 

  6. Busin M, Madi S, Santorum P, Scorcia V, Beltz J. Ultrathin Descemet’s stripping automated endothelial keratoplasty with the microkeratome double-pass technique: two-year outcomes. Ophthalmology. 2013;120(6):1186–94.

    Article  PubMed  Google Scholar 

  7. Terry MA, Straiko MD, Goshe JM, Li JY, Davis-Boozer D. Descemet’s stripping automated endothelial keratoplasty: the tenuous relationship between donor thickness and postoperative vision. Ophthalmology. 2012;119(10):1988–96.

    Article  PubMed  Google Scholar 

  8. Daoud YJ, Munro AD, Delmonte DD, Stinnett S, Kim T, Carlson AN, Afshari NA. Effect of cornea donor graft thickness on the outcome of Descemet stripping automated endothelial keratoplasty surgery. Am J Ophthalmol. 2013;156(5):860–6.e1.

    Article  PubMed  Google Scholar 

  9. Shinton AJ, Tsatsos M, Konstantopoulos A, Goverdhan S, Elsahn AF, Anderson DF, Hossain P. Impact of graft thickness on visual acuity after Descemet’s stripping endothelial keratoplasty. Br J Ophthalmol. 2012;96(2):246–9.

    Article  PubMed  Google Scholar 

  10. Van Cleynenbreugel H, Remeijer L, Hillenaar T. Descemet stripping automated endothelial keratoplasty: effect of intraoperative lenticule thickness on visual outcome and endothelial cell density. Cornea. 2011;30(11):1195–200.

    PubMed  Google Scholar 

  11. Woodward MA, Raoof-Daneshvar D, Mian S, Shtein RM. Relationship of visual acuity and lamellar thickness in Descemet stripping automated endothelial keratoplasty. Cornea. 2013;32(5):e69–73.

    Article  PubMed  Google Scholar 

  12. Phillips PM, Phillips LJ, Maloney CM. Preoperative graft thickness measurements do not influence final BSCVA or speed of vision recovery after Descemet stripping automated endothelial keratoplasty. Cornea. 2013;32(11):1423–7.

    Article  PubMed  Google Scholar 

  13. Melles GR, Lander F, Rietveld FJ. Transplantation of Descemet’s membrane carrying viable endothelium through a small scleral incision. Cornea. 2002;21(4):415–8.

    Article  PubMed  Google Scholar 

  14. Price MO, Giebel AW, Fairchild KM, Price Jr FW. Descemet’s membrane endothelial keratoplasty: prospective multicenter study of visual and refractive outcomes and endothelial survival. Ophthalmology. 2009;116(12):2361–8.

    Article  PubMed  Google Scholar 

  15. Anshu A, Price MO, Price Jr FW. Risk of corneal transplant rejection significantly reduced with Descemet’s membrane endothelial keratoplasty. Ophthalmology. 2012;119(3):536–40.

    Article  PubMed  Google Scholar 

  16. Guerra FP, Anshu A, Price MO, Giebel AW, Price FW. Descemet’s membrane endothelial keratoplasty: prospective study of 1-year visual outcomes, graft survival, and endothelial cell loss. Ophthalmology. 2011;118(12):2368–73.

    Article  PubMed  Google Scholar 

  17. Dapena I, Ham L, Melles GR. Endothelial keratoplasty: DSEK/DSAEK or DMEK--the thinner the better? Curr Opin Ophthalmol. 2009;20(4):299–307.

    Article  PubMed  Google Scholar 

  18. Ham L, Balachandran C, Verschoor CA, van der Wees J, Melles GJ. Visual rehabilitation rate after isolated Descemet membrane transplantation: Descemet membrane endothelial keratoplasty. Arch Ophthalmol. 2009;127(3):252–5.

    Article  PubMed  Google Scholar 

  19. Terry MA, Shamie N, Chen ES, Phillips PM, Hoar KL, Friend DJ. Precut tissue for Descemet’s stripping automated endothelial keratoplasty: vision, astigmatism, and endothelial survival. Ophthalmology. 2009;116(2):248–56.

    Article  PubMed  Google Scholar 

  20. Jun B, Kuo AN, Afshari NA, Carlson AN, Kim T. Refractive change after Descemet stripping automated endothelial keratoplasty surgery and its correlation with graft thickness and diameter. Cornea. 2009;28(1):19–23.

    Article  PubMed  Google Scholar 

  21. Price MO, Baig KM, Brubaker JW, Price Jr FW. Randomized, prospective comparison of precut vs surgeon-dissected grafts for Descemet stripping automated endothelial keratoplasty. Am J Ophthalmol. 2008;146(1):36–41.

    Article  PubMed  Google Scholar 

  22. Yoo SH, Kymionis GD, Deobhakta AA, Ide T, Manns F, Culbertson WW, O’Brien TP, Alfonso EC. One-year results and anterior segment optical coherence tomography findings of Descemet stripping automated endothelial keratoplasty combined with phacoemulsification. Arch Ophthalmol. 2008;126(8):1052–5.

    Article  PubMed  Google Scholar 

  23. Price MO, Fairchild KM, Price DA, Price Jr FW. Descemet’s stripping endothelial keratoplasty five-year graft survival and endothelial cell loss. Ophthalmology. 2011;118(4):725–9.

    Article  PubMed  Google Scholar 

  24. Price MO, Gorovoy M, Price Jr FW, Benetz BA, Menegay HJ, Lass JH. Descemet’s stripping automated endothelial keratoplasty: three-year graft and endothelial cell survival compared with penetrating keratoplasty. Ophthalmology. 2013;120(2):246–51.

    Article  PubMed  Google Scholar 

  25. Kumar DA, Dua HS, Agarwal A, Jacob S. Postoperative spectral-domain optical coherence tomography evaluation of pre-Descemet endothelial keratoplasty grafts. J Cataract Refract Surg. 2015 Jul;41(7):1535–6.

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Deepinder K. Dhaliwal MD, LAc .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer India

About this chapter

Cite this chapter

Dhaliwal, D.K., Kouchouk, A.M. (2016). Graft Thickness and Its Relationship to Visual Outcome in Endothelial Keratoplasty. In: Jacob, S. (eds) Mastering Endothelial Keratoplasty . Springer, New Delhi. https://doi.org/10.1007/978-81-322-2821-9_12

Download citation

  • DOI: https://doi.org/10.1007/978-81-322-2821-9_12

  • Published:

  • Publisher Name: Springer, New Delhi

  • Print ISBN: 978-81-322-2819-6

  • Online ISBN: 978-81-322-2821-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics