Disorders of Growth and Development: Diagnosis and Treatment

  • Anil Bhansali
  • Anuradha Aggarwal
  • Girish Parthan
  • Yashpal Gogate


Who needs to be evaluated for short stature?


Celiac Disease Short Stature Gonadal Steroid Noonan Syndrome Serum IGF1 
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Further Readings

  1. 1.
    Carel JC, Ecosse E, Landier F, Meguellati-Hakkas D, Kaguelidou F, Rey G, Coste J. Long-term mortality after recombinant growth hormone treatment for isolated growth hormone deficiency or childhood short stature: preliminary report of the French SAGhE study. J Clin Endocrinol Metab. 2012;97:416–25.CrossRefPubMedGoogle Scholar
  2. 2.
    Cohen P, Rogol A, Deal C, Saenger P, Reiter E, Ross J, et al. Consensus statement on the diagnosis and treatment of children with idiopathic short stature: a summary of the Growth Hormone Research Society, the Lawson Wilkins Pediatric Endocrine Society, and the European Society for Paediatric Endocrinology Workshop. J Clin Endocrinol Metab. 2008;93:4210–7.CrossRefPubMedGoogle Scholar
  3. 3.
    Cook D, Yuen K, Biller B, Kemp S, Vance M. American Association of Clinical Endocrinologists medical guidelines for clinical practice for growth hormone use in growth hormone-deficient adults and transition patients-2009 update. Endocr Pract. 2009;15(S2):1–29.CrossRefPubMedGoogle Scholar
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    DeGroot L, Jameson J. Endocrinology. Philadelphia: Saunders/Elsevier; 2010.Google Scholar
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    Hindmarsh PC. Current indications for growth hormone therapy, 2nd ed, revised. Endocr Dev. Basel: Karger; 2010;18:92–108.Google Scholar
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    Kelberman D, Dattani MT. The role of transcription factors implicated in anterior pituitary development in the aetiology of congenital hypopituitarism. Ann Med. 2006;38:560–77.CrossRefPubMedGoogle Scholar
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    MartÍnez AS, Domené HM, Ropelato MG, Jasper HG, Pennisi PA, Escobar ME, Heinrich JJ. Estrogen priming effect on growth hormone (GH) provocative test: a useful tool for the diagnosis of GH deficiency. J Clin Endocrinol Metab. 2000;85:4168–72.PubMedGoogle Scholar
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    Melmed S, Williams R. Williams textbook of endocrinology. Philadelphia: Elsevier/Saunders; 2011.Google Scholar
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    Molitch M, Clemmons D, Malozowski S, Merriam G, Vance M. Evaluation and treatment of adult growth hormone deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab. 2011;96:1587–609.CrossRefPubMedGoogle Scholar
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    Savage MO, Blum WF, Ranke MB, Postel-Vinay MC, Cotterill AM, Hall K, et al. Clinical features and endocrine status in patients with growth hormone insensitivity (Laron syndrome). J Clin Endocrinol Metab. 1993;77:1465–71.PubMedGoogle Scholar
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    Shalet SM. Consensus guidelines for the diagnosis and treatment of growth hormone (GH) deficiency in childhood and adolescence: summary statement of the GH Research Society. J Clin Endocrinol Metab. 2000;85:3990–3.CrossRefGoogle Scholar
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    Spiliotis BE, August GP, Hung W, Sonis W, Mendelson W, Bercu BB. Growth hormone neurosecretory dysfunction: a treatable cause of short stature. JAMA. 1984;251:2223–30.CrossRefPubMedGoogle Scholar
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    Stanley T. Diagnosis of growth hormone deficiency in childhood. Curr Opin Endocrinol Diabetes Obes. 2012;19:47–52.CrossRefPubMedPubMedCentralGoogle Scholar
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    Van der Eerden BCJ, Karperien M, Wit JM. Systemic and local regulation of the growth plate. Endocr Rev. 2003;24:782–801.CrossRefPubMedGoogle Scholar

Copyright information

© Springer India 2016

Authors and Affiliations

  • Anil Bhansali
    • 1
  • Anuradha Aggarwal
    • 2
  • Girish Parthan
    • 3
  • Yashpal Gogate
    • 4
  1. 1.Department of EndocrinologyPostgraduate Institute of Medical Education and ResearchChandigarhIndia
  2. 2.Paras HospitalPatnaIndia
  3. 3.Renal MedicityCochinIndia
  4. 4.Harmony Health HubNasikIndia

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