The New Massive Data: miRnomics and Its Application to Therapeutics

  • Mohammad Ahmed Khan
  • Maryam Mahfooz
  • Ghufrana Abdus Sami
  • Hashim AlSalmi
  • Abdullah E. A. Mathkoor
  • Ghazi A. Damanhauri
  • Mahmood Rasool
  • Mohammad Sarwar Jamal


Genomic medicine is highly dependent on understanding the biological processes regulating gene expression. In this reference, the discovery of phenomena of RNA interference in 1998 served as turning point for the field of genomic medicine. It was observed that the double stranded RNA (dsRNA) is capable of silencing specific genes in Caenorhabditis elegans [12]. Later, studies on RNA interference have revealed that RNA interference operates in many species and serves in silencing genes. In C. elegans, the inhibitory potential of RNA was induced by introducing endogeneous long dsRNA’s while in mammalian cells, the introduction of small 21 nt RNA’s could induce RNAi. [10].


Generation AMOs Lock Nucleic Acid Genomic Medicine miRNA Inhibition miRNA Sponge 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer India 2016

Authors and Affiliations

  • Mohammad Ahmed Khan
    • 1
  • Maryam Mahfooz
    • 2
  • Ghufrana Abdus Sami
    • 3
  • Hashim AlSalmi
    • 4
  • Abdullah E. A. Mathkoor
    • 3
  • Ghazi A. Damanhauri
    • 4
  • Mahmood Rasool
    • 5
  • Mohammad Sarwar Jamal
    • 4
  1. 1.National Institute of BiologicalsNoidaIndia
  2. 2.Department of Computer ScienceJamia Millia IslamiaNew DelhiIndia
  3. 3.Department of BiotechnologyJamia Millia IslamiaNew DelhiIndia
  4. 4.King Fahd Medical Research Center (KFMRC)King Abdulaziz UniversityJeddahSaudi Arabia
  5. 5.Center of Excellence in Genomic Medicine Research (CEGMR)King Abdulaziz UniversityJeddahSaudi Arabia

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