Structureomics in Systems-Based Drug Discovery

  • Lumbini R. Yadav
  • Pankaj Thapa
  • Lipi Das
  • Ashok K. Varma


Selection of the appropriate drug target is crucial and furthermore its association with small molecule binding partners is the subject of extensive studies. Drug discovery has evolved from the traditional serendipity to system based approaches of using the three dimensional structures of biological molecules. This chapter provides a brief description about the contribution of large number of proteins structures in drug discovery. This further elucidates the target selection and its role in reducing the time and efforts required for drug development.


Nuclear Magnetic Resonance Drug Discovery Nuclear Magnetic Resonance Spectroscopy Lead Molecule Solution Nuclear Magnetic Resonance 



Structure-based drug designing


Absorption distribution, metabolism, and excretion


Scanning electron microscopy


Transmission electron microscopy


X-ray diffractometer


Protein structure initiative


Structural Genomics Consortium


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Copyright information

© Springer India 2016

Authors and Affiliations

  • Lumbini R. Yadav
    • 1
  • Pankaj Thapa
    • 1
  • Lipi Das
    • 1
  • Ashok K. Varma
    • 1
  1. 1.Varma LabAdvanced Centre for Treatment, Research and Education in CancerKhargharIndia

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