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Effects of Methylphenidate and Atomoxetine on Development of the Brain

  • Berrin Zuhal Altunkaynak
  • Mehmet Emin Onger
  • Aysin Pınar Turkmen
  • Kıymet Kubra Yurt
  • Gamze Altun
  • Murat Yuce
  • Suleyman Kaplan
Chapter

Abstract

The development of the neuronal system is a long and highly complex process. Similarly, brain development, while it is part of this process, entails more complex molecular mechanisms and hormonal changes that are independent of this process. Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disease that is generally seen in children and adolescents. Psychostimulants such as methylphenidate (MPH) have been commonly used for the treatment of ADHD. However, atomoxetine (ATX), a non-stimulant noradrenalin (NA) reuptake blocker, is used as an alternative for the therapy of ADHD. Exposure to these drugs gives rise to behavioral, functional, and physiological effects on the brain during the postnatal developmental period. This chapter provides general information about the brain development process and the effects of MPH and ATX on neurodevelopment in the light of the actual findings and the literature.

Keywords

Attention Deficit Hyperactivity Disorder Dentate Gyrus Brain Development Bulimia Nervosa Attention Deficit Hyperactivity Disorder 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer India 2016

Authors and Affiliations

  • Berrin Zuhal Altunkaynak
    • 1
  • Mehmet Emin Onger
    • 1
  • Aysin Pınar Turkmen
    • 1
  • Kıymet Kubra Yurt
    • 1
  • Gamze Altun
    • 1
  • Murat Yuce
    • 2
    • 1
  • Suleyman Kaplan
    • 1
  1. 1.Department of Histology and Embryology, Medical School, Medical FacultyOndokuz Mayıs UniversitySamsunTurkey
  2. 2.Department of Child and Adolescent Psychiatry, Medical SchoolOndokuz Mayıs UniversitySamsunTurkey

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