Melatonin: Basic and Clinical Aspects

  • Agata Carpentieri
  • Vanessa Areco
  • Gabriela Díaz de Barboza
  • María Angélica Rivoira
  • Solange Guizzardi
  • Nori Tolosa de Talamoni


Melatonin (MEL), the “hormone of darkness,” is an indolamine mainly secreted at night by the pineal gland. It is also synthesized by other tissues, being the enterochromaffin cells the most important extrapineal sites. The ubiquity, pleiotropy, and complexity are the three terms that summarize the properties and actions of MEL. Two well-characterized enzymes participate in its synthesis: N-acetyltransferase, the first-rate limiting enzyme in MEL production, which converts serotonin to N-acetylserotonin (NAS), and hydroxyindole-O-methyltransferase, which converts NAS to MEL. Most of the MEL’s actions are mediated by membrane (MT1 and MT2) and nuclear (ROR/RZR) receptors. However, some MEL effects seem to be independent of the involvement of receptors or related to Ca2+-binding proteins. The signal transduction pathways triggered by MEL involve the AC/cAMP/PKA/CREB, phospholipase C (PLC)-β and PLC-η, and Rafs/MEK1/2/ERK1/2 cascades. MEL participates in the circadian rhythms, the modulation of season changes, in reproduction, as well as an antioxidant, antiapoptotic, anti-inflammatory, oncostatic, and anticonvulsant drug. Exogenous MEL is employed in a number of physiopathological conditions, mainly for the treatment of sleep disorders and jet lag. The antioxidant properties of MEL have been proven to be beneficial to patients with rheumatoid arthritis, females with infertility, elderly patients with primary essential hypertension, and multiple sclerosis patients. The spectrum of the uses of MEL seems to be wide, although more investigation is needed in order to know better the molecular mechanisms and the possible side effects.


Irritable Bowel Syndrome Pineal Gland Alzheimer Disease Mouse Zinc Double Finger Extrapineal Tissue 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Dr. Nori T. de Talamoni and Carpentieri A. are members of career from CONICET. Areco V. is recipient of a fellowship from the Instituto Nacional del Cancer.


This work was supported by grants from CONICET [PIP 2013–2015] and SECYT (UNC) (Dr. Nori T. de Talamoni).


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Copyright information

© Springer India 2016

Authors and Affiliations

  • Agata Carpentieri
    • 1
    • 2
  • Vanessa Areco
    • 1
  • Gabriela Díaz de Barboza
    • 1
  • María Angélica Rivoira
    • 1
  • Solange Guizzardi
    • 1
  • Nori Tolosa de Talamoni
    • 1
  1. 1.“Dr. Cañas” Laboratory, Biochemistry and Molecular Biology, Faculty of Medical SciencesUniversidad Nacional de Córdoba, INICSA (CONICET-UNC)CórdobaArgentina
  2. 2.Biological Chemistry, Faculty of DentistryUniversidad Nacional de CórdobaCórdobaArgentina

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