Neurobiology and Pharmacological Prevention of Suicide in Mood Disorders

  • Xenia Gonda
  • Zoltan Rihmer
  • Peter Dome


Suicide is a complex and multicausal human behaviour, and because of these characteristics, understanding and delineating its neurobiological background is challenging. In spite of a vast array of suicide studies applying different approaches, we are still far away from understanding suicide in its complexity and integrating the already acquired knowledge into a comprehensive model on suicidal behaviour. This would however highly aid the development of pharmacological agents to prevent suicide especially in the framework of affective episodes in mood disorder patients. In the first part of the chapter, our already existing knowledge concerning the neurobiological background of suicide will be overviewed, while in the second part, we summarise the most relevant findings concerning pharmacological prevention of suicide in mood disorders.


Prefrontal Cortex Suicide Attempt Suicidal Behaviour Mood Stabiliser Lithium Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer India 2016

Authors and Affiliations

  1. 1.Department of Psychiatry and PsychotherapySemmelweis UniversityBudapestHungary
  2. 2.Laboratory of Suicide Research and PreventionNational Institute for Psychiatry and AddictologyBudapestHungary

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