Neurocognitive Deficit in Bipolar Disorders

  • Dimos Dimelis
  • Xenia Gonda
  • Konstantinos N. Fountoulakis


Neurocognitive deficits are increasingly recognized in bipolar disorder patients and have been found to be evident and prevalent in all neurocognitive domains, showing differential association with different affective phases and being also present in euthymic periods. This chapter summarizes the existing information and data on neurocognitive characteristics, alterations, and deficits in bipolar disorder, as well as giving an outlook on their possible use as endophenotypes aiding research and diagnostics and differential diagnostics in bipolar patients. Understanding neurocognitive deficits in bipolar disorders should play a key role in our conceptualization of these illnesses and in the conceptualization of individual cases, because severe deficits affecting all neurocognitive domains are present in all affective episodes, show a progressive nature, and also characterize euthymic phases as residual symptoms deteriorating daily function and quality of life. Therefore, neurocognitive deficits should be incorporated in the understanding, evaluation, and treatment of bipolar disorders and could also aid to expand our current disease models and understanding of the neurobiology and genetic underpinnings of bipolar disorder.


Bipolar Disorder Executive Function Emotion Recognition Verbal Memory Intelligence Quotient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer India 2016

Authors and Affiliations

  • Dimos Dimelis
    • 1
  • Xenia Gonda
    • 2
    • 3
  • Konstantinos N. Fountoulakis
    • 4
  1. 1.Department of Psychiatry424 Military HospitalThessalonikiGreece
  2. 2.Department of Psychiatry and PsychotherapySemmelweis UniversityBudapestHungary
  3. 3.Laboratory of Suicide Research and PreventionNational Institute for Psychiatry and AddictologyBudapestHungary
  4. 4.Division of Neurosciences, 3rd Department of Psychiatry, School of MedicineAristotle University of ThessalonikiThessalonikiGreece

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