Depression: Correlations with Thyroid Hormones in Major Depressive Disorder

  • Dominika Berent


Thyroid hormones (THs) were found to play significant role in brain development and its further functioning in adulthood. Several studies deliver data on THs’ meaning in the pathogeny of major depressive disorder (MDD). Supplementation of THs is considered to augment and accelerate antidepressant treatment. THs transport and signaling act via complicated protein net which can be disturbed at any level. This is to review a contemporary knowledge of THs transport, signaling, metabolism, and role in MDD. The relevant English literature from PubMed/MEDLINE and EMBASE databases was searched using the terms: thyroid hormones, transporters, receptors, deiodinases, and depression. Own clinical observations of THs significance for depression severity and outcome are also shared. Studies on variability in thyroid function may provide strategies on more efficient, personalized treatment in MDD patients.


Thyroid Hormone Major Depressive Disorder Major Depressive Disorder Subclinical Hypothyroidism Major Depressive Disorder Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The author have no competing interests to declare.


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© Springer India 2016

Authors and Affiliations

  1. 1.Department of PsychiatryMedical University of WarsawWarsawPoland

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