Sleep Abnormalities as a Diagnostic Tool for Major Depressive Disorder

  • Alan B. Douglass
  • Marcus Ward
  • Timothy Roerhrs
  • Cynthia L. Arfken
  • Nash N. Boutrous


The purposes of this chapter are to describe the REM sleep control system for researchers not primarily working in that area and to recount the history of its use in psychiatric research. For the uninitiated, there are many quirks and complexities in the psychiatric sleep literature which make it difficult to synthesize the findings of papers from different decades.


Major Depressive Disorder Dorsal Raphe Nucleus NREM Sleep Paradoxical Sleep Major Depressive Disorder Group 
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Copyright information

© Springer India 2016

Authors and Affiliations

  • Alan B. Douglass
    • 1
  • Marcus Ward
    • 1
  • Timothy Roerhrs
    • 2
  • Cynthia L. Arfken
    • 3
  • Nash N. Boutrous
    • 4
  1. 1.Royal Ottawa Mental Health CenterUniversity of Ottawa Institute of Mental Health ResearchOttawaCanada
  2. 2.Henry Ford Sleep Disorders and Research Center, Henry Ford Health System, Department of Psychiatry and Behavioral NeurosciencesWayne State UniversityDetroitUSA
  3. 3.Department of Psychiatry and Behavioral NeurosciencesWayne State UniversityDetroitUSA
  4. 4.Department of PsychiatryUniversity of Missouri – Kansas CityKansas CityUSA

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