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Bibliometric Study of Scientific Research on Melatonin During the Last 25 Years

  • Francisco López-Muñoz
  • Francisco J. Povedano
  • Cecilio Álamo
Chapter

Abstract

We have carried out a bibliometric analysis of scientific publications related to the the pineal gland and melatonin during the period 1900-2014, to detail its distribution, and to interpret the changes that have affected its development. We selected (EMBASE and MEDLINE databases) documents that contained in their title the descriptors pineal*, epiphys*, melatonin* or agomelatin*. As bibliometric indicators of production, we applied Price’s Law, and others as doubling time and annual growth rate of scientific literature. We also applied Lotka’s Law, Bradford’s Law, and calculated the national Participation Index (PaI) for pineal gland, melatonin, and agomelatine in 20 most productive countries in this topic. We obtained 30,617 original documents (17,046 corresponded to pineal gland, and 14,967 to melatonin). Our results indicate fulfilment of Price’s Law, since scientific production on this topic undergoes exponential growth (correlation coefficient r = 0.9528, vs. r = 0.9139 after linear adjustment). The most used journal in the dissemination of documents is Journal of Pineal Research (the core or first Bradford’s zone), with 2,168 papers. The principal producer country is the United States (PaI = 24.11), followed by Germany (PaI = 6.71), Japan (PaI = 5.78), France (PaI = 5.77), and Spain (PaI = 5.33). Productivity on pineal gland and melatonin has undergone exponential growth in the period 1900–2014, without evidence a saturation point.

Keywords

Impact Factor Pineal Gland Science Citation Index Scientific Production Productivity Index 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Axelrod J, Weissbach H. Enzymatic O-methylation of N-acetylserotonin to melatonin. Science. 1960;131:1312.CrossRefPubMedGoogle Scholar
  2. 2.
    Bordons M, Zulueta MA. Evaluación de la actividad científica a través de indicadores bibliométricos. Rev Esp Cardiol. 1999;52:790–800.CrossRefPubMedGoogle Scholar
  3. 3.
    Bradford SC. Documentation. London: Crosby Lockwood and Son Ltd.; 1948.Google Scholar
  4. 4.
    Bünning E. Die physiologischen Uhr. Berlin: Springer; 1958.CrossRefGoogle Scholar
  5. 5.
    Coleman R. Impact factors: use and abuse in biomedical research. Anat Rec. 1999;257:54–7.CrossRefPubMedGoogle Scholar
  6. 6.
    Dubocovich ML. Pharmacology and function of melatonin receptors. FASEB J. 1988;2:2765–33.PubMedGoogle Scholar
  7. 7.
    Fiske VM, Bryant GK, Putnam J. Effect of light in the weight of the pineal in the rat. Endocrinology. 1960;66:489–91.CrossRefGoogle Scholar
  8. 8.
    Garfield E. Citation indexing. Its theory and application in science, technology and humanities. New York: Wiley; 1979.Google Scholar
  9. 9.
    Gross OV. Bradford’s law and the Keenam-Atherton data. Am Doc. 1967;18:46.CrossRefGoogle Scholar
  10. 10.
    Ha TC, Tan SB, Soo KC. The journal impact: too much of an impact. Ann Acad Med Singapore. 2006;35:911–6.PubMedGoogle Scholar
  11. 11.
    Hoffman RA, Reiter RJ. Pineal gland: influence on gonads of male hamsters. Science. 1965;148:1609–11.CrossRefPubMedGoogle Scholar
  12. 12.
    Johnson MH, Cohen J, Grudzinskas G. The uses and abuses of bibliometrics. Rep Biomed Online. 2012;24:485–6.CrossRefGoogle Scholar
  13. 13.
    Kappers JA. The development, topographical relations and innervation of the epiphysis cerebri in the albino rat. Z Zellforsch Mikrosk Anat. 1960;52:163–215.CrossRefPubMedGoogle Scholar
  14. 14.
    Kitay JI, Altschule MD. The pineal gland. A review of the physiologic literature. Cambridge: Harvard University Press; 1954.Google Scholar
  15. 15.
    Lerner AB, Case JD, Takahashi Y, et al. Isolation of melatonin, the pineal gland factor that lightens melanocytes. J Am Chem Soc. 1958;80:2587.CrossRefGoogle Scholar
  16. 16.
    López-Muñoz F, Marín F, Boya J. Evaluación bibliométrica de la producción científica española en neurociencia. Análisis de las publicaciones de difusión internacional durante el periodo 1984–1993. Rev Neurol. 1996;24:417–26.PubMedGoogle Scholar
  17. 17.
    López-Muñoz F, Boya J, Marín F, Calvo JL. Scientific research on the pineal gland and melatonin: a bibliometric study for the period 1966–1994. J Pineal Res. 1996;20:115–24.CrossRefPubMedGoogle Scholar
  18. 18.
    López-Muñoz F, Alamo C, Rubio G, García-García P, Martín-Agueda B, Cuenca E. Bibliometric analysis of biomedical publications on SSRIs during the period 1980–2000. Depres Anxiety. 2003;18:95–103.CrossRefGoogle Scholar
  19. 19.
    López-Muñoz F, Vieta E, Rubio G, García-García P, Alamo C. Bipolar disorder as an emerging pathology in the scientific literature: a bibliometric approach. J Affect Dis. 2006;92:161–70.CrossRefPubMedGoogle Scholar
  20. 20.
    López-Muñoz F, Álamo C, Guerra JA, Rubio G. Twenty-four years of scientific publications on selective serotonin reuptake inhibitors (SSRI): a bibliometric approach. In: Shirley AC, editor. Focus on serotonin uptake inhibitor research. New York: Nova Science Publishers; 2006. p. 191–219.Google Scholar
  21. 21.
    López-Muñoz F, Álamo C, Quintero-Gutiérrez FJ, García-García P. A bibliometric study of international scientific productivity in attention-deficit hyperactivity disorder covering the period 1980–2005. Eur Child Adolesc Psychiatry. 2008;17:381–91.CrossRefPubMedGoogle Scholar
  22. 22.
    López-Muñoz F, García-García P, Sáiz-Ruiz J, et al. A bibliometric study of the use of the classification and diagnostic systems in psychiatry over the last 25 years. Psychopathology. 2008;41:214–25.CrossRefPubMedGoogle Scholar
  23. 23.
    López-Muñoz F, Marín F, Alamo C. El devenir histórico de la glándula pineal. I: de válvula espiritual a sede del alma. Rev Neurol. 2010;50:50–7.PubMedGoogle Scholar
  24. 24.
    López-Muñoz F, Marín F, Alamo C. El devenir histórico de la glándula pineal. II: de sede del alma a órgano neuroendocrino. Rev Neurol. 2010;50:117–25.PubMedGoogle Scholar
  25. 25.
    López-Muñoz F, Shen WW, Shinfuku N, et al. A bibliometric study on second-generation antipsychotic drugs in the Asia-Pacific Region. J Exp Clin Med. 2014;6:111–7.CrossRefGoogle Scholar
  26. 26.
    López-Muñoz F, Povedano FJ, García-García P, Quintero J, Álamo C. Evolution of international scientific production on attention-deficit hyperactivity disorder: a bibliometric analysis of the last 34 years. In: López-Muñoz F, Álamo C, editors. Attention Deficit Hyperactivity Disorder (ADHD): epidemiology, treatment and prevention. New York: Nova Science Publishers; 2015. p. 1–22.Google Scholar
  27. 27.
    López-Muñoz F, Sanz-Fuentenebro FJ, Rubio G, García-García P, Álamo C. Quo vadis clozapine? A bibliometric study of 45 years of research in international context. Int J Mol Sci. 2015;16:23012–34.CrossRefPubMedPubMedCentralGoogle Scholar
  28. 28.
    Lotka AJ. The frequency distribution of scientific productivity. J Wash Acad Sci. 1926;16:317–23.Google Scholar
  29. 29.
    Price DJS. Little science, big science. New York: Columbia University Press; 1963.Google Scholar
  30. 30.
    Pritchard A. Statistical bibliography or bibliometrics. J Doc. 1969;25:348–69.Google Scholar
  31. 31.
    Quay WB. Reduction of mammalian pineal weight and lipid during continuous light. Gen Comp Endocrinol. 1961;1:211–7.CrossRefPubMedGoogle Scholar
  32. 32.
    Quay WB. Circadian rhythm in rat pineal serotonin and its modifications by estrous cycle and photoperiod. Gen Comp Endocrinol. 1963;3:473–9.CrossRefPubMedGoogle Scholar
  33. 33.
    Vollrath L. The pineal organ. In: Handbuch der Mikroskopischen Anatomie des Menschen, vol. VI/7. Berlin: Springer; 1981.Google Scholar
  34. 34.
    Welsh MG. Current methodologies for the study of pineal morphophysiology. J Pineal Res. 1994;16:113–20.CrossRefPubMedGoogle Scholar
  35. 35.
    Wurtman RJ, Axelrod J. The pineal gland. Sci Am. 1965;213:50–60.CrossRefPubMedGoogle Scholar
  36. 36.
    Wurtman RJ, Roth W, Altschule MD, Wurtman JJ. Interactions of the pineal and exposure to continuous light on organ weights of female rats. Acta Endocrinol (Kbh). 1961;36:617–24.Google Scholar
  37. 37.
    Wurtman RJ, Axelrod J, Philips LS. Melatonin synthesis in the pineal gland: control by light. Science. 1963;142:1071–3.CrossRefPubMedGoogle Scholar
  38. 38.
    Wurtman RJ, Axelrod J, Fischer JE. Melatonin synthesis in the pineal gland: effect of light mediated by the sympathetic nervous system. Science. 1964;143:1328–30.CrossRefGoogle Scholar

Copyright information

© Springer India 2016

Authors and Affiliations

  • Francisco López-Muñoz
    • 1
    • 2
    • 3
  • Francisco J. Povedano
    • 1
  • Cecilio Álamo
    • 4
  1. 1.Faculty of Health SciencesCamilo José Cela UniversityMadridSpain
  2. 2.Neuropsychopharmacology UnitHospital 12 de Octubre Research Institute (i+12)MadridSpain
  3. 3.Portucalense Institute of Neuropsychology and Cognitive and Behavioural NeurosciencesPortucalense UniversityPortoPortugal
  4. 4.Department of Biomedical Sciences (Pharmacology Area), Faculty of Medicine and Health SciencesUniversity of Alcalá, Alcalá de HenaresMadridSpain

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