Neuropsychological Models of Depression

  • Stephan Moratti
  • Alberto Fernández
  • Rosa Jurado
  • Gabriel Rubio


Depression is a psychiatric disorder with high prevalence in Mental Health Centers and in the general population. In recent decades there has been a growing interest in applying models of emotion and motivation to the study of affective disorders. Two of the most relevant models in this field have investigated the relationship between depression and positive and negative affects and also the association between emotional functioning and cortical brain asymmetries in subjects with depression.

In this chapter the contributions of psychophysiology studies of depression focused on the startle response and cortical brain asymmetry are described. Regarding the studies using electroencephalogram (EEG) and magnetoencephalogram (MEG) we have summarized results from studies came from depressed versus controls, as well as the differences found in patients with melancholic and atypical depression. Finally a number of considerations are made to improve the methods of study that may be useful to better understand the psychophysiological processes of patients with depression.


Major Depressive Disorder Depressed Patient Unpleasant Stimulus Poststroke Depression Alpha Asymmetry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer India 2016

Authors and Affiliations

  • Stephan Moratti
    • 1
  • Alberto Fernández
    • 2
  • Rosa Jurado
    • 3
    • 4
  • Gabriel Rubio
    • 5
    • 6
    • 7
  1. 1.Department of Basic Psychology I, Faculty of PsychologyComplutense UniversityMadridSpain
  2. 2.Department of Psychiatry, Faculty of MedicineComplutense UniversityMadridSpain
  3. 3.Department of Basic Psychology II, Faculty of PsychologyComplutense UniversityMadridSpain
  4. 4.Psychology Department, Faculty of Health SciencesUniversidad Camilo Jose Cela, Villanueva de la CañadaMadridSpain
  5. 5.Psychiatry Service12 de Octubre University HospitalMadridSpain
  6. 6.Neuropsychopharmacology UnitHospital 12 de Octubre Research Institute (i+12)MadridSpain
  7. 7.Department of Psychiatry, Faculty of MedicineComplutense UniversityMadridSpain

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