New Galenic Formulations of Melatonin

  • Pilar García-García
  • Francisco López-Muñoz
  • Cecilio Álamo


Melatonin is a neurohormone that plays an important role in maintaining the body’s internal biological clock (the sleep-wake and thermoregulatory system). Its main role is in relation to circadian rhythms and it also acts as an antioxidant. The pharmacokinetic characteristics of melatonin include a short half-life and extensive metabolism, leading to a short action when exogenous formulations are administered. For this reason, different formulations have been developed to increase and prolong the actions of melatonin.


Sleep Quality Pittsburgh Sleep Quality Index Galenic Formulation Primary Insomnia Melatonin Administration 
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Copyright information

© Springer India 2016

Authors and Affiliations

  • Pilar García-García
    • 1
  • Francisco López-Muñoz
    • 2
    • 3
    • 4
  • Cecilio Álamo
    • 1
  1. 1.Department of Biomedical Sciences (Pharmacology Area), Faculty of Medicine and Health SciencesUniversity of AlcaláMadridSpain
  2. 2.Faculty of Health SciencesCamilo José Cela UniversityMadridSpain
  3. 3.Neuropsychopharmacology UnitHospital 12 de Octubre Research Institute (i+12)MadridSpain
  4. 4.Portucalense Institute of Neuropsychology and Cognitive and Behavioural NeurosciencesPortucalense UniversityPortoPortugal

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