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Bioactive Potential of Sponge Secondary Metabolites

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Marine Sponges: Chemicobiological and Biomedical Applications

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Abstract

The advent of spongothymidine and spongouridine from the Caribbean sponge Tethya crypta turned the attraction of chemists toward sponges for their unique and novel compounds which have a broad spectrum of biological activity and anticancer property in particular. They find the candidates for the development of new drug analogues with the expected biological activity. The sponge compounds are having a series of bioactivity broadly classified into three groups, viz., pharmacological activity, antagonizing activities, and antifouling activity. Each group is dealt with the allied bioactivities which were observed on the range of sponge compounds during evaluation studies. The biological activities are grouped depending on their similarity and type of testing. The structural groups of the compounds include terpenoids, alkaloids, heterocycles, acetylenic compounds, steroids, and nucleosides. The uniqueness of the selected compounds derived from sponges with the observed bioactivity is discussed.

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Acknowledgment

I am grateful to Dr. A. Gopalakrishnan, Director, ICAR-Central Marine Fisheries Research Institute, Kochi for his support and permission to publish this work.

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  1. Mandapam Regional Centre, Marine Fisheries PO, ICAR-Central Marine Fisheries Research Institute, Ramanathapuram, 623 520, Tamil Nadu, India

    Irudayaraj Rajendran

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    Ramjee Pallela

  2. Biomineralogy & Extreme Biomimetics, Institute of Experimental Physics, Freiberg, Sachsen, Germany

    Hermann Ehrlich

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Rajendran, I. (2016). Bioactive Potential of Sponge Secondary Metabolites. In: Pallela, R., Ehrlich, H. (eds) Marine Sponges: Chemicobiological and Biomedical Applications. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2794-6_10

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