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Fungi Fights Fungi: Tip-off in Antifungal Chemotherapy

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Recent Trends in Antifungal Agents and Antifungal Therapy

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Abstract

Fungal infections have taken a new spectrum due to the increased incidence of multi-drug resistant fungal pathogens. Freedom of choice for drugs to treat fungal infections is also narrow because of lesser probability of discovering drugs that would bypass affecting human cells and target fungal cells producing fewer side effects in patients. An approach has gained prominence in research is to look for bioactive antifungal compounds from natural sources and discover new classes of antifungals to control the recent emergence of fungal infections. Most of antifungal drugs are originated from fungi. A conservative estimate of total number of fungal species on this planet would exceed 106 if taken into account the ones yet to be discovered from diverse habitats ranging from forest land to marine ecosystem. While attempting to summarize the status of reported fungi-derived antifungal compounds discovered since ancient times, the subset of such compounds were found to be anticancer too. Antifungal compounds with the promise of inducing challenge to rediscover the new effective molecules from drug prototype are also discussed.

Anupam Roy and Santi M. Mandal are equally contributed in literature survey.

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Funding

Anupam Roy is thankful to CSIR, India, for providing CSIR Individual Fellowship to Anupam Roy (CSIR sanction No- 9/1103 (0001)2 k13-EMR-I).

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Authors and Affiliations

  1. Department of Microbiology, Vidyasagar University, Midnapore, 721102, West Bengal, India

    Santi M. Mandal

  2. Department of Chemistry, Agriculturtal and Food Engineering Department, Indian Institute of Technology Kharagpur, Kharagpur, 721302, India

    Anupam Roy & Shanker Lal Shrivastava

  3. Amity Institute of Biotechnology, Amity University, Sec 125, Noida, 201303, India

    Debarati Paul

  4. CSIR-Institute of Microbial Technology, Sector 39A, Chandigarh, 160036, India

    Suresh Korpole

  5. Department of Biotechnology, North Bengal University, Siliguri, Darjeeling, 734013, India

    Ranadhir Chakraborty

  6. Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India

    Amit Basak

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  1. Santi M. Mandal
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  3. Debarati Paul
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  5. Shanker Lal Shrivastava
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  6. Ranadhir Chakraborty
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  7. Amit Basak
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Correspondence to Santi M. Mandal or Amit Basak .

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  1. Department of Chemistry Agricultural and Food Engineering Department, Indian Institute of Technology Kharagpur, Kharagpur, West Bengal, India

    Amit Basak

  2. Department of Biotechnolgy, University of North Bengal, Darjeeling, West Bengal, India

    Ranadhir Chakraborty

  3. Department of Microbiology, Vidyasagar University, Midnapore, West Bengal, India

    Santi M. Mandal

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Mandal, S.M. et al. (2016). Fungi Fights Fungi: Tip-off in Antifungal Chemotherapy. In: Basak, A., Chakraborty, R., Mandal, S. (eds) Recent Trends in Antifungal Agents and Antifungal Therapy. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2782-3_1

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