Fluid Resuscitation

  • Jonathan Leung
  • Derek Hicks


  • The physiology of fluid compartments and fluid deficit in health and disease states are different.

  • Crystalloids are the initial fluid of choice for resuscitation in most situations.

  • Fluid resuscitation requires rational treatment end points during, i.e. fluid responsiveness, in order to prevent negative effects.

  • The effect of over-resuscitation with fluid can be detrimental and lethal.


Fluid Resuscitation Fluid Responsiveness Stroke Volume Index Predict Fluid Responsiveness Oncotic Pressure 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Barsoum N, Kleeman C. Now and then, the history of parenteral fluid administration. Am J Nephrol. 2002;22(2–3):284–9.Google Scholar
  2. 2.
    Latta T. Injections in cholera. Lond Med Gaz. 1832:379–82.Google Scholar
  3. 3.
    O’Shaugnessy WB. Experiments on the blood in cholera. Lancet. 1831–1832;i:490.Google Scholar
  4. 4.
    Latta T. Malignant cholera. Lancet. 1831–1832; ii:274–7.Google Scholar
  5. 5.
    Longson D, et al. National Institute for Health and Clinical Excellence (2013) Intravenous fluid therapy in adults in hospital [Online]. 2013;174. Available at: Accessed on 13 Sept 2014.
  6. 6.
    Matejtschuk P, Dash CH, Gascoine E. Production of human albumin solution: a continually developing colloid. Br J Anaesth. 2000;85(6):887–95.CrossRefPubMedGoogle Scholar
  7. 7.
    Cochrane Injuries Group Albumin Reviewers. Human albumin administration in critically ill patients: systematic review of randomised controlled trials. BMJ. 1998;317:235–40.CrossRefGoogle Scholar
  8. 8.
    Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R, SAFE Study Investigators. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med. 2004;350:2247–56.CrossRefPubMedGoogle Scholar
  9. 9.
    Brunkhorst FM, German Competence Network Sepsis (SepNet). Intensive insulin therapy and pentastarch resuscitation in severe sepsis. N Engl J Med. 2008;358(2):125–39.CrossRefPubMedGoogle Scholar
  10. 10.
    Perner A 6S Trial Group, Scandinavian Critical Care Trials Group. Hydroxyethyl starch 130/0.42 versus Ringer’s acetate in severe sepsis. N Engl J Med. 2012;367(2):124–34.CrossRefGoogle Scholar
  11. 11.
    Myburgh JA, CHEST Investigators, Australian and New Zealand Intensive Care Society Clinical Trials Group, et al. Hydroxyethyl starch or saline for fluid resuscitation in intensive care. N Engl J Med. 2012;367(20):1901–11.CrossRefPubMedGoogle Scholar
  12. 12.
    Wiedemann HP, National Heart, Lung, and Blood Institute Acute Respiratory Distress Syndrome (ARDS) Clinical Trials Network, et al. Comparison of two fluid-management strategies in acute lung injury. N Engl J Med. 2006;354(24):2564–75.CrossRefPubMedGoogle Scholar
  13. 13.
    Marik PE, Baram M, Vahid B. Does central venous pressure predict fluid responsiveness? A systematic review of the literature and the tale of seven mares. Chest. 2008;134(1):172–8.CrossRefPubMedGoogle Scholar

Copyright information

© Springer India 2016

Authors and Affiliations

  1. 1.Department of Emergency MedicineHomerton University Hospital NHS Foundation TrustLondonUK
  2. 2.Department of Emergency MedicineWhipps Cross University Hospital, Barts HealthLondonUK

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