Abstract
The HELLP syndrome is a serious complication in pregnancy characterized by haemolysis, elevated liver enzymes and low platelet count occurring in 0.5–0.9 % of all pregnancies and in 10–20 % of cases with severe preeclampsia.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Sibai BM. Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Obstet Gynecol. 2004;103:981–91.
Sibai BM. Imitators of severe pre-eclampsia/eclampsia. Clin Perinatol. 2004;31:835–52.
Martin JN, Brewer JM, Wallace K, Sunesara I, Canizaro A, et al. Hellp syndrome and composite major maternal morbidity: importance of Mississippi classification system. J Matern Fetal Neonatal Med. 2013;26(12):1201–6.
Yıldırım G, Güngördük K, Aslan H, Gül A, Bayraktar M, et al. Comparison of maternal and perinatal outcomes of severe pre-eclampsia, eclampsia and HELLP syndrome. J Turk Ger Gynecol Assoc. 2011;12(2):90–6.
Ciantar E, Walker JJ. Pre-eclampsia, severe pre-eclampsia and hemolysis, elevated liver enzymes and low platelets syndrome: what is new? Womens Health. 2011;7(5):555–69.
Steinborn A, Rebmann V, Scharf A, Sohn C, Grosse-Wilde H. Soluble HLA-DR levels in the maternal circulation of normal and pathologic pregnancy. Am J Obstet Gynecol. 2003;188:473–9.
Agatisa PK, Ness RB, Roberts JM, Costantino JP, Kuller LH, McLaughlin MK. Impairment of endothelial function in women with a history of preeclampsia: an indicator of cardiovascular risk. Am J Physiol Heart Circ Physiol. 2004;286:H1389–93.
Araujo AC, Leao MD, Nobrega MH, et al. Characteristics and treatment of hepatic rupture caused by HELLP syndrome. Am J Obstet Gynecol. 2006;195:129–33.
Romero R, Chaiworapongsa T. Preeclampsia: a link between trophoblast dysregulation and an antiangiogenic state. J Clin Invest. 2013;123(7):2775–7.
Holub M, Bodamer OA, Item C, Mühl A, Pollak A, Stöckler- Ipsiroglu S. Lack of correlation between fatty acid oxidation disorders and haemolysis, elevated liver enzymes, low platelets (HELLP) syndrome? Acta Paediatr. 2005;94:48–52.
Sibai BM. Diagnosis, controversies, and management of the syndrome of hemolysis, elevated liver enzymes, and low platelet count. Obstet Gynecol. 2004;103(5 Pt 1):981–91.
Serdar A, Fırat E, Ark C, Aydın CA. Partial HELLP syndrome: maternal, perinatal, subsequent pregnancy and long-term maternal outcomes. J Obstet Gynaecol Res. 2014;40(4):932–40.
Martin JN. Milestones in the quest for best management of patients with HELLP syndrome (microangiopathic hemolytic anemia, hepatic dysfunction, thrombocytopenia). Int J Gynaecol Obstet. 2013;121(3):202–7.
Qureshi NS, Tomlinson AJ. Prenatal corticosteroid therapy for elevated liver enzyme/low platelet count syndrome: a case report. J Reprod Med. 2005;50:64–6.
Sultan P, Butwick A. Platelet counts and coagulation tests prior to neuraxial anesthesia in patients with preeclampsia: a retrospective analysis. Clin Appl Thromb Hemost. 2013;19(5):529–34.
Vigil-De GP. Maternal deaths due to eclampsia and HELLP syndrome. Int J Gynaecol Obstet. 2009;104(2):90–4.
Haram K, Svendsen E, Abildgaard U. The HELLP syndrome: clinical issues and management. A review. BMC Pregnancy Childbirth. 2009;9:8.
Prakash J. The kidney in pregnancy: a journey of three decades. Indian J Nephrol. 2012;22(3):159–67.
Sibai BM. Evaluation and management of severe preeclampsia before 34 weeks’ gestation. Am J Obstet Gynecol. 2011;205(3):191–8.
Mamouni N, Bougern H, Derkaoui A, Bendahou K, Fakir S, et al. HELLP syndrome: report of 61 cases and literature review. Pan Afr Med J. 2012;11:30.
Haram K, Svendsen E, Abildgaard U. The HELLP syndrome: clinical issues and management: a review. BMC Pregnancy Childbirth. 2009;9:8. doi:10.1186/1471-2393-9-8.
Martin Jr JN. Milestones in the quest for best management of patients with HELLP syndrome. Int J Gynecol Obetet. 2013;12:202–7.
Burwick RM, Feinberg BB. Eculizumab for the treatment of preeclampsia/HELLP syndrome. Placenta. 2013;34:201–3.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer India
About this chapter
Cite this chapter
Shah, P.K., Daigavane, M., DSouza, N. (2016). HELLP Syndrome. In: Gandhi, A., Malhotra, N., Malhotra, J., Gupta, N., Bora, N. (eds) Principles of Critical Care in Obstetrics. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2692-5_28
Download citation
DOI: https://doi.org/10.1007/978-81-322-2692-5_28
Published:
Publisher Name: Springer, New Delhi
Print ISBN: 978-81-322-2690-1
Online ISBN: 978-81-322-2692-5
eBook Packages: MedicineMedicine (R0)