Antepartum Hemorrhage



In addition to unacceptably high perinatal mortality [1], antepartum hemorrhage (APH) is an important contributory cause of maternal mortality and morbidity in the developing countries. Although it is not preventable, an early diagnosis and treatment can improve maternal and perinatal outcome to a large extent.


Vaginal Delivery Cesarean Delivery Disseminate Intravascular Coagulation Vaginal Bleeding Placenta Previa 
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  1. 1.
    Jaju KG, Kulkarni AP, Mundada SP. Study of perinatal outcome in relation to APH. International Journal of Recent trends in Science and Technology. 2014;11(3):355–8.Google Scholar
  2. 2.
    Studd I, Tan SL, Chervenak FA, et al. Progress in obstetrics and gynecology. Edinburgh: Elsevier Ltd; 2008.Google Scholar
  3. 3.
    Konje JC, Taylor DJ. Bleeding in late pregnancy. In: James DK, Steer PJ, Weiner CP, Gonik B, editors. High risk pregnancy management options. 2nd ed. London: Harcourt; 2000.Google Scholar
  4. 4.
    Chan EE, To WW. Antepartum hemorrhage of unknown origin: what is its clinical significance? Acta Obstet Gynecol Scand. 1999;78(3):186–90.CrossRefPubMedGoogle Scholar
  5. 5.
    Chilaka VN, Konje JC, Clarke S, et al. Practice observed: is speculum examination on admission a necessary procedure in the management of all cases of antepartum haemorrhage? J Obstet Gynaecol. 2000;20(4):396–8.CrossRefPubMedGoogle Scholar
  6. 6.
    Sakornbut E, Leeman L, Fontaine P. Late pregnancy bleeding. Am Fam Physician. 2007;75(8):1199–206.PubMedGoogle Scholar
  7. 7.
    Love CD, Wallace EM. Pregnancies complicated by placenta previa: what is appropriate management? Br J Obstet Gynecol. 1996;103(9):864–7.CrossRefGoogle Scholar
  8. 8.
    Mustafa SA, Brizot ML, Carvalho MH, et al. Transvaginal ultrasonography in predicting placenta previa at delivery: a longitudinal study. Ultrasound Obstet Gynecol. 2002;20(4):356–9.CrossRefPubMedGoogle Scholar
  9. 9.
    Faiz AS, Cv A. Etiology and risk factors for placenta previa: an overview and meta-analysis of observational studies. J Matern Fetal Neonatal Med. 2003;13(3):175–90.CrossRefPubMedGoogle Scholar
  10. 10.
    Nielsen TF, Hagberg H, Ljungblad U. Placenta previa and antepartum haemorrhage after previous caesarean section. Gynecol Obstet Invest. 1989;27:88–90.CrossRefPubMedGoogle Scholar
  11. 11.
    Wu S, Kocherginsky M, Hibbard N. Abnormal placentation: twenty-year analysis. Am J Obstet Gynecol. 2005;192:1458–61.CrossRefPubMedGoogle Scholar
  12. 12.
    Monica G, Lilja C. Placenta previa, cigarette smoking and recurrence risk. Acta Obstet Gynecol Scand. 1995;74:341–5.CrossRefPubMedGoogle Scholar
  13. 13.
    Ananth C, Smulian JC, Vintzileos AM. The effect of placenta previa on neonatal mortality: a population-based study in the United States, 1989 through 1997. Am J Obstet Gynecol. 2003;188:1299–304.CrossRefPubMedGoogle Scholar
  14. 14.
    Bricker L, Neilson JP. Routine ultrasound in late pregnancy (after 24 weeks gestation). Cochrane Database Syst Rev. 2000;(2):CD001451.Google Scholar
  15. 15.
    Smith RS, Lauria MR, Comstock CH, et al. Transvaginal ultra-sonography for all placentas that appear to be low-lying or over the internal cervical os. Ultrasound Obstet Gynecol. 1997;9:22–4.CrossRefPubMedGoogle Scholar
  16. 16.
    Timor-Tritsch IE, Yunis RA. Confirming the safety of transvaginal sonography in patients suspected of placenta previa. Obstet Gynecol. 1993;81(5 Pt 1):742–4.PubMedGoogle Scholar
  17. 17.
    Hertzberg BS, Bowie JD, Carroll BA, et al. Diagnosis of placenta previa during the third trimester: role of transperineal sonography. AJR Am J Roentgenol. 1992;159:83–7.CrossRefPubMedGoogle Scholar
  18. 18.
    ACOG Committee on Obstetric Practice. Placenta accreta. ACOG Committee opinion. Number 266, January 2002: placenta accreta. Obstet Gynecol. 2002;99(1):169–70.CrossRefGoogle Scholar
  19. 19.
    Taipale P, Hiilesmaa V, Ylostalo P. Transvaginal ultrasonography at 18–23 weeks in predicting placenta previa at delivery. Ultrasound Obstet Gynecol. 1998;12:422–5.CrossRefPubMedGoogle Scholar
  20. 20.
    Becker RH, Vonk R, Mende BC, et al. The relevance of placental location at 20–23 gestational weeks for prediction of placenta previa at delivery: evaluation of 8650 cases. Ultrasound Obstet Gynecol. 2001;17:496–501.CrossRefPubMedGoogle Scholar
  21. 21.
    Dashe JS, McIntire DD, Ramus RVI, et al. Persistence of placenta previa according to gestational age at ultrasound detection. Obstet Gynecol. 2002;99(5 Pt 1):692–7.CrossRefPubMedGoogle Scholar
  22. 22.
    Crowley P. Prophylactic corticosteroids for preterm birth. Cochrane Database Syst Rev. 2000;(2):CD000065.Google Scholar
  23. 23.
    American College of Obstetrics and Gynecology. ACOG practice bulletin. Prevention of RhD alloimmunization. Number 4, May 1999 (replaces educational bulletin Number 147, 1990). Clinical management guidelines for obstetrician-gynecologists. Int J Gynaecol Obstet. 1999;66(1):63–70.Google Scholar
  24. 24.
    Cobo E, Conde-Agudelo A, Delgado J, et al. Cervical cerclage: an alternative for the management of placenta previa? Am J Obstet Gynecol. 1998;179:122–5.CrossRefPubMedGoogle Scholar
  25. 25.
    Neilson JP. Interventions for suspected placenta previa. Cochrane Database Syst Rev. 2003;(2):CD001998.Google Scholar
  26. 26.
    Sharma A, Suri V, Gupta L. Tocolytic therapy in conservative management of symptomatic placenta previa. Int J Gynaecol Obstet. 2004;84:109–13.CrossRefPubMedGoogle Scholar
  27. 27.
    Wing DA, Paul RH, Millar LK. Management of the symptomatic placenta previa: a randomized, controlled trial of inpatient versus outpatient expectant management. Am J Obstet Gynecol. 1996;175(4 Pt 1):806–11.CrossRefPubMedGoogle Scholar
  28. 28.
    Hayman R, Arukumaran S, Steer PJ. Uterine compression sutures: surgical management of postpartum hemorrhage. Obstet Gynecol. 2002;99:202–6.CrossRefGoogle Scholar
  29. 29.
    Comstock CH, Love JJ, Bronsteen RA, et al. Sonographic detection of placenta accreta in the second and third trimesters of pregnancy. Am J Obstet Gynecol. 2004;190:1135–40.CrossRefPubMedGoogle Scholar
  30. 30.
    ACOG Committee on Obstetric Practice. ACOG Committee opinion. Number 266, January 2002: placenta accreta. Obstet Gynecol. 2002;99:169–70.CrossRefGoogle Scholar
  31. 31.
    Ananth C, Wilcox AJ. Placental abruption and perinatal mortality in the United States. Am J Epidemiol. 2001;153(4):332–7.CrossRefPubMedGoogle Scholar
  32. 32.
    Neilson JP. Interventions for treating placental abruption. Cochrane Database Syst Rev. 2003;(1):CD003247.Google Scholar
  33. 33.
    Rasmussen S, Irgens LM, Bergsjo P, et al. The occurrence of placental abruption in Norway 1967–1991. Acta Obstet Gynecol Scand. 1996;75:222–8.CrossRefPubMedGoogle Scholar
  34. 34.
    Hladky K, Yankowitz J. Hansen WE Placental abruption. Obstet Gynecol Surv. 2002;57:299–305.CrossRefPubMedGoogle Scholar
  35. 35.
    Miller JM, Boudreaux MC, Regan FA. A case-control study of cocaine use in pregnancy. Am J Obstet Gynecol. 1995;172(l Pt 1):180–5.CrossRefPubMedGoogle Scholar
  36. 36.
    Kramer MS, Usher RH, Pollack R, et al. Etiologic determinants of abruptio placentae. Obstet Gynecol. 1997;89(2):221–6.CrossRefPubMedGoogle Scholar
  37. 37.
    Fleming AD. Abruptio placentae. Crit Care Clin. 1991;7:865–75.PubMedGoogle Scholar
  38. 38.
    Ananth CV, Smulian JC, Demissie K, et al. Placental abruption among singleton and twin births in the United States: risk factor profiles. Am J Epidemiol. 2001;153:771–8.CrossRefPubMedGoogle Scholar
  39. 39.
    Karegard M, Gennser G. Incidence and recurrence rate of abruptio placentae in Sweden. Obstet Gynecol. 1986;67(4):523–8.PubMedGoogle Scholar
  40. 40.
    Fraser R, Watson R. Bleeding during the latter half of pregnancy. In: Chalmers I, Enkin M, Keirse MJNC, editors. Effective care in pregnancy and childbirth. Oxford: Oxford University Press; 1989. p. 594–611.Google Scholar
  41. 41.
    Lewis G, Drife J, Botting B, et al. Why mothers die. Report on confidential enquiries into maternal deaths in the United Kingdom 1994–1996. London: Department of Health and Her Majesty’s Stationary Office; 1998. p. 104–14.Google Scholar
  42. 42.
    Prual A, Bouvier-Colle MH, de Bemis L, et al. Severe maternal morbidity from direct obstetric causes in West Africa: incidence and case fatality rates. Bull World Health Org. 2000;78(5):593–602.PubMedPubMedCentralGoogle Scholar
  43. 43.
    Witlin AG, Sibai BM. Perinatal and maternal outcome following abruptio placentae. Hypertens Pregnancy. 2001;20(2):195–203.CrossRefPubMedGoogle Scholar
  44. 44.
    Glantz C, Purnell L. Clinical utility of sonography in the diagnosis and treatment of placental abruption. J Ultrasound Med. 2002;21:837–40.PubMedGoogle Scholar
  45. 45.
    Knab DR. Abruptio placentae: an assessment of the time and method of delivery. Obstet Gynecol. 1978;52:625–9.PubMedGoogle Scholar
  46. 46.
    Abdella TN, Sibai M, Hays JM, et al. Relationship of hypertensive diseases to abruptio placentae. Obstet Gynecol. 1984;63:365–70.PubMedGoogle Scholar
  47. 47.
    Okonofua FE, Olatubosum A. Caesarean versus vaginal delivery in abruptio placentae associated with live fetuses. Int J Gynecol Obstet. 1985;23:471–4.CrossRefGoogle Scholar
  48. 48.
    Rasmussen S, Irgens LM, Bergsjo P, et al. Perinatal mortality and case fatality after placental abruption in Norway 1967–1991. Acta Obstet Gynecol Scand. 1996;75:229–34.CrossRefPubMedGoogle Scholar
  49. 49.
    Towers CV, Pircon RA, Heppard M. Is tocolysis safe in the management of third-trimester bleeding? Am J Obstet Gynecol. 1999;180(6 Pt 1):1572–8.CrossRefPubMedGoogle Scholar
  50. 50.
    Altman D, Carroli G, Duley L, et al. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? Lancet. 2002;359(9321):1877–90.CrossRefPubMedGoogle Scholar
  51. 51.
    Neilson IP. Antepartum haemorrhage. In: Edmonds DK, editor. Dewhursts textbook of obstetrics and gynaecology for postgraduates. 6th ed. London: Blackwell Science Publishers; 1999. p. 134–44.Google Scholar
  52. 52.
    Cotton DB, Read TA, Paul RH, et al. The conservative management of placenta previa. Am J Obstet Gynecol. 1980;137:687–95.CrossRefPubMedGoogle Scholar
  53. 53.
    Oyalese KO, Turner M, Lees C, et al. Vasa previa: an avoidable obstetric tragedy. Obstet Gynecol Surv. 1999;54:138–45.CrossRefGoogle Scholar
  54. 54.
    Ananth CV, Oyelese Y, Yeo L, et al. Placental abruption in the United States, 1979 through 2001: temporal trends and potential determinants. Am J Obstet Gynecol. 2005;192:191–8.CrossRefPubMedGoogle Scholar
  55. 55.
    Nelle M, Zilow EP, Kraus M, et al. The effect of Leboyer delivery on blood viscosity and other hemorrheologic parameters in term neonates. Am J Obstet Gynecol. 1993;169:189–93.CrossRefPubMedGoogle Scholar
  56. 56.
    Apt L, Downey WS. Melena neonatorum: the swallowed blood syndrome; a simple test for the differentiation of adult and fetal hemoglobin in bloody stools. J Pediatr. 1955;47:6–12.CrossRefPubMedGoogle Scholar
  57. 57.
    Oyelese Y, Catanzarite V, Prefumo F, et al. Vasa previa: the impact of prenatal diagnosis on outcomes. Obstet Gynecol. 2004;103(5 Pt 1):937–42.CrossRefPubMedGoogle Scholar
  58. 58.
    Lee W, Lee VL, Kirk JS, et al. Vasa previa: prenatal diagnosis, natural evolution, and clinical outcome. Obstet Gynecol. 2000;95:572–6.CrossRefPubMedGoogle Scholar

Copyright information

© Springer India 2016

Authors and Affiliations

  1. 1.Department of Obstetrics & GynaecologyS.N. Medical CollegeAgraIndia

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