Systemic Lupus Erythematosus and Pregnancy
Systemic lupus erythematosus (SLE) is a multisystem connective tissue disease characterized by multi-organ involvement; characteristic inflammatory lesions of the skin, joints, serous membranes, kidneys and CNS; and its association with high titres of autoantibodies to an array of autoantigens. Its clinical course is often one of the disease flares followed by variable periods of remission. Approximately 90 % of the affected population are young women in their second or third decades of life. Therefore, SLE is the commonest connective tissue disorder encountered during pregnancy, and it has been widely studied by researchers across the globe. Evidence shows the foetal and maternal outcomes are adversely affected by the disease.
KeywordsSystemic Lupus Erythematosus Preterm Birth Foetal Growth Restriction Anticardiolipin Antibody Gestational Hypertension
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