Abstract
Systemic lupus erythematosus (SLE) is a multisystem connective tissue disease characterized by multi-organ involvement; characteristic inflammatory lesions of the skin, joints, serous membranes, kidneys and CNS; and its association with high titres of autoantibodies to an array of autoantigens. Its clinical course is often one of the disease flares followed by variable periods of remission. Approximately 90 % of the affected population are young women in their second or third decades of life. Therefore, SLE is the commonest connective tissue disorder encountered during pregnancy, and it has been widely studied by researchers across the globe. Evidence shows the foetal and maternal outcomes are adversely affected by the disease.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Mintz G, Niz J, Gutierrez G, et al. Prospective study of pregnancy in systemic lupus erythematosus. Results of a multidisciplinary approach. J Rheumatol. 1986;13:732.
Malaviya AN, Singh RR, Singh YN, Kapoor SK, Kumar A. Prevalence of systemic lupus erythematosus in India. Lupus. 1993;2:115–8.
Hochberg MC. Prevalence of systemic lupus erythematosus in England and Wales (1981–82). Ann Rheum Dis. 1987;46:664–6.
Jonsson H, Nived O, Surfelt G. Outcome in systemic lupus erythematosus: a prospective study of patients from a defined population. Medicine (Baltimore). 1989;68:141–50.
Uramoto KM, Michet Jr CJ, Thumboo J, et al. Trends in the incidence and mortality 1950–1992. Arthritis Rheum. 1992;42:46–50.
Fraga A, Mintz G, Orozco J, Orozco JH. Sterility and fertility rates, foetal wastage and maternal morbidity in Systemic lupus erythematosus. J Rheumatol. 1974;1:1293–8.
Garsenstein M, Pollak VE, Karik RM. Systemic lupus erythematosus and pregnancy. N Engl J Med. 1962;267:165–9.
Lockshin MD. Pregnancy does not cause systemic lupus erythematosus to worsen. Arthritis Rheum. 1989;32:665.
Urowitz MB, Gladman DD, Farewell VT, et al. Lupus and pregnancy studies. Arthritis Rheum. 1993;36:1392.
Petri M, Howard D, Repke J. Frequency of lupus flare in pregnancy. The Hopkins Lupus Pregnancy Center Experience. Arthritis Rheum. 1991;34:1538.
Lockshin MD, Reinitz E, Druzin ML, et al. Lupus pregnancy. Case–control prospective study demonstrating absence of lupus exacerbation during or after pregnancy. Am J Med. 1984;77:893.
Denney JM, Porter TF, Branch DW. Autoimmune disease, Chapter 43, High risk pregnancy, management options, 4th ed. Elsevier Saunders. Egerman RS, Ramsey RD.
Kao LW, et al. Hypertensive disease in pregnancies complicated by systemic lupus erythematosus. Am J Obstet Gynecol. 2005;193:1676.
Johnson MJ, Petri M, Witter FR, Repke JT. Evaluation of preterm delivery in a systemic lupus erythematosus pregnancy clinic. Obstet Gynecol. 1995;86:396.
Hochberg MC. Updating The American College of Rheumatology revised criteria for the classification of Systemic lupus erythematosus. Arthritis Rheum. 1997;40:1725.
Repke JT. Hypertensive disorders of pregnancy. Differentiating preeclampsia from active systemic lupus erythematosus. J Reprod Med. 1998;43:350.
Buyon JP, Cronstein BN, Morris M, et al. Serum complement values (C3 and C4) to differentiate between systemic lupus activity and pre-eclampsia. Am J Med. 1986;81:194.
Al-Herz A, Schulzer M, Esdaile JM. Survey of antimalarial use in lupus pregnancy and lactation. J Rheumatol. 2002;29:700.
Costedoat-Chalumeau N, Amoura Z, Duhaut P, et al. Safety of hydroxychloroquine in pregnant patients with connective tissue diseases: a study of one hundred thirty-three cases compared with a control group. Arthritis Rheum. 2003;48:3207.
Clowse ME, Magder L, Witter F, Petri M. Hydroxychloroquine in lupus pregnancy. Arthritis Rheum. 2006;54:3640.
Clowse ME, Magder L, Petri M. Cyclophosphamide for lupus during pregnancy. Lupus. 2005;14:593.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2016 Springer India
About this chapter
Cite this chapter
Konar, H., Chaudhuri, P. (2016). Systemic Lupus Erythematosus and Pregnancy. In: Gandhi, A., Malhotra, N., Malhotra, J., Gupta, N., Bora, N. (eds) Principles of Critical Care in Obstetrics. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2686-4_19
Download citation
DOI: https://doi.org/10.1007/978-81-322-2686-4_19
Published:
Publisher Name: Springer, New Delhi
Print ISBN: 978-81-322-2684-0
Online ISBN: 978-81-322-2686-4
eBook Packages: MedicineMedicine (R0)