Management of Sickle Cell Crisis in Pregnancy



Sickle cell disease is a group of inherited single-gene autosomal recessive disorders caused by the ‘sickle’ gene, which affects haemoglobin structure. SCD has its origins in sub-Saharan Africa and the Middle East; hence, it is most prevalent in individuals of African descent as well as in the Caribbean, Middle East, parts of India and the Mediterranean and South and Central America. Owing to population migration, SCD is now of increasing importance worldwide [1].


Sickle Cell Anaemia Sickle Cell Sickle Cell Trait Peripartum Cardiomyopathy Acute Chest Syndrome 


  1. 1.
    Stuart MJ, Nagel RL. Sickle cell disease. Lancet. 2004;364:1343–60.CrossRefPubMedGoogle Scholar
  2. 2.
    Weatherall D, Akinyanju O, Fucharoen S, Olivieri N, Musgrove P, et al. Inherited disorders of haemoglobin. In: Jamison DT, Breman JG, Measham AR, Alleye G, Claeson M, Evans DB, editors. Disease control priorities in developing countries. 2nd ed. Washington, DC/New York: The World Bank/Oxford University Press; 2006. p. 663–80.Google Scholar
  3. 3.
    Powars DR, Sandhu M, Niland-Weiss J, Johnson C, Bruce S, Manning PR. Pregnancy in sickle cell disease. Obstet Gynecol. 1986;67:217–28.CrossRefPubMedGoogle Scholar
  4. 4.
    Villers MS, Jamison MG, De Castro LM, James AH. Morbidity associated with sickle cell disease in pregnancy. Am J Obstet Gynecol. 2008;199:125.e1–5.CrossRefGoogle Scholar
  5. 5.
    Clarkson JG. The ocular manifestations of sickle-cell disease: a prevalence and natural history study. Trans Am Ophthalmol Soc. 1992;90:481–504.PubMedPubMedCentralGoogle Scholar
  6. 6.
    Sickle Cell Society. Standards for the clinical care of adults with sickle cell disease in the UK. London: Sickle Cell Society; 2008.Google Scholar
  7. 7.
    Rees DC, Olujohungbe AD, Parker NE, Stephens AD, Telfer P, Wright J, British Committee for Standards in Haematology General Haematology Task Force by the Sickle Cell Working Party. Guidelines for the management of acute painful crisis in sickle cell disease. Br J Haematol. 2003;120:744–52.CrossRefPubMedGoogle Scholar
  8. 8.
    National Confidential Enquiry into Patient Outcome and Death. A sickle crisis? A report of the national confidential enquiry into patient outcome and death. London: NCEPOD; 2008.Google Scholar
  9. 9.
    Howard RJ, Tuck SM, Pearson TC. Pregnancy in sickle cell disease in the UK: results of a multicentre survey of the effect of prophylactic blood transfusion on maternal and fetal outcome. Br J Obstet Gynaecol. 1995;102:947–51.CrossRefPubMedGoogle Scholar
  10. 10.
    Ohene-Frempong K, Weiner SJ, Sleeper LA, Miller ST, Embury S, Moohr JW, et al. Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood. 1998;91:288–94.PubMedGoogle Scholar
  11. 11.
    Smith-Whitley K, Zhao H, Hodinka RL, Kwiatkowski J, Cecil R, Cecil T, et al. Epidemiology of human parvovirus B19 in children with sickle cell disease. Blood. 2004;103:422–7.CrossRefPubMedGoogle Scholar
  12. 12.
    Styles LA, Abboud M, Larkin S, Lo M, Kuypers FA. Transfusion prevents acute chest syndrome predicted by elevated secretory phospholipase A2. Br J Haematol. 2007;136:343–4.CrossRefPubMedGoogle Scholar
  13. 13.
    Tuck SM, Studd JW, White JM. Sickle cell disease in pregnancy complicated by anti-U antibody. Case report. Br J Obstet Gynaecol. 1982;89:91–2.CrossRefPubMedGoogle Scholar
  14. 14.
    Anyaegbunam A, Morel MI, Merkatz IR. Antepartum fetal surveillance tests during sickle cell crisis. Am J Obstet Gynecol. 1991;165:1081–3.CrossRefPubMedGoogle Scholar
  15. 15.
    Legardy JK, Curtis KM. Progestogen-only contraceptive use among women with sickle cell anemia: a systematic review. Contraception. 2006;73:195–204.CrossRefPubMedGoogle Scholar

Copyright information

© Springer India 2016

Authors and Affiliations

  1. 1.Obstetrician and GynecologistJeevan Jyoti Hospital and Medical Research Centre, Jeevan Jyoti Test Tube Baby CentreGorakhpurIndia
  2. 2.Maharani Laxmi Bai Medical CollegeJhansiIndia

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