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Pathobiological Role of CRP in Diseases: Clinical Medical Applications of CRP

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Biology of C Reactive Protein in Health and Disease

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Abstract

Although C-reactive protein has been designated as a marker for inflammation and recently as a marker in assessment of risk in cardiovascular disorders from a number of studies across the globe, the role of CRP in other diseases have also been studied. Some of the major diseases in which CRP levels have been correlated with disease states are detailed in this chapter. Bearing a hepatic origin, C-reactive protein is a protein found in the plasma and belongs to the pentraxin family participating in the inflammatory reaction. The CRP concentration in response to injury or infection becomes escalated about 1000-fold over and above normally expressed levels. CRP is known for its function as a mediator in the classical innate immunity pathway and constitutes a part of both humoral and cellular effector systems of inflammation. Although it is well known as a marker for acute-phase response in injury of the tissue, during the infection of the host by pathogenic agents like viruses, bacteria, parasites, and inflammations, it has recently gained the status of a disease marker in cardiovascular disorders and also has been reported for its clinical and pathological significance. In this chapter we highlight the status of C-reactive protein (CRP) in different disorders and pathological conditions.

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Authors and Affiliations

  1. Department of Zoology, Behala College, Kolkata, West Bengal, India

    Waliza Ansar

  2. National Institute of Science Education, School of Biological Sciences, Bhubaneswar, Odisha, India

    Shyamasree Ghosh

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  1. Waliza Ansar
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  2. Shyamasree Ghosh
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Ansar, W., Ghosh, S. (2016). Pathobiological Role of CRP in Diseases: Clinical Medical Applications of CRP. In: Biology of C Reactive Protein in Health and Disease. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2680-2_6

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