Abstract
Lower leg ulcer is a circumscribed necrosis of epidermis, skin, and occasionally also muscular fascia, tendon, or even underlying bone with sluggish granulation and delayed covering by keratinocytes migrating from the ulcer margins. Following skin microinjury the colonization of denuded surface by local skin and floating down perineal bacterial flora takes place. The predisposing factors are venous stasis with excess capillary filtrate, high tissue fluid pressure, erythrocyte extravasation, hemosiderosis and fibrosis, or ischemia in atherosclerosis and diabetes with decreased arterial supply of nutrients, or lymph stasis with excess tissue fluid, high tissue fluid pressure and fibrosis, or excessive fat deposition in the subcutis in pathological obesity with excess tissue fluid and high tissue fluid pressure. The common denominator, irrespective of predisposing factors, is colonization of the denuded surfaces by bacteria. Although bacteria may not necessarily be the primary etiological factor, they certainly are responsible for progression of ulcer or delayed healing.
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References
Kloos WE, Musselwhite MS. Distribution and persistence of staphylococcus and micrococcus species and other aerobic bacteria on human skin. Appl Microbiol. 1975;30:381–5.
Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI, Knight R. Bacterial community variation in human body habitats across space and time. Science. 2009;326:1694–7.
Galkowska H, Olszewski WL, Wojewodzka U. Keratinocyte and dermal vascular endothelial cell capacities remain unimpaired in the margin of chronic venous ulcer. Arch Dermatol Res. 2005;296:286–95.
Olszewski WL, Zaleska M, Stelmach E, Swoboda-Kopec E, Jain P, Agrawal K, Gogia S, Gogia A, Andziak P, Durlik M. Cryptic bacteria of lower limb deep tissues as a possible cause of inflammatory and necrotic changes in ischemia, venous stasis and varices, and lymphedema. Surg Infect. 2015;16(3):313–22.
Halbert AR, Stacey MC, Rohr JB, Jopp-Mckay A. The effect of bacterial colonization on venous ulcer healing. Australas J Dermatol. 1992;33:75–80.
O’Meara S, Al-Kurdi D, Ovington LG. Antibiotics and antiseptics for venous leg ulcers. Cochrane Database Syst Rev. 2008;(12):CD003557.
Holloway GA, Johansen KH, Barnes RW, et al. Multicenter trial of cadexomer iodine to treat venous stasis ulcer. West J Med. 1989;151:35–8.
Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG, TASC II Working Group. Inter-society consensus for the management of peripheral arterial disease (TASC II). J Vasc Surg. 2007;45(Suppl S):S5–67.
Andziak P, Olszewski WL, Moscicka-Wesolowska M, Interewicz B, Swoboda E, Stelmach E. Skin own bacteria may aggravate inflammatory and occlusive changes in atherosclerotic arteries of lower limbs. Int Angiol. 2012;31:474–82.
O’Meara S, Cullum N, Majid M, Sheldon T. Systematic reviews of wound care management: (3) antimicrobial agents for chronic wounds; (4) diabetic foot ulceration. Health Technol Assess. 2000;4:1–247.
Lipsky BA, Peters EJ, Berendt AR, Senneville E, Bakker K, Embil JM, Urbančič-Rovan V, Jeffcoate WJ, International Working Group on Diabetic Foot. Specific guidelines for the treatment of diabetic foot infections 2011. Diabetes Metab Res Rev. 2012;28 Suppl 1:234–5.
Lipsky BA, et al. 2012 infectious diseases society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis. 2012;54:1679–84.
Galkowska H, Wojewodzka U, Olszewski WL. Low recruitment of immune cells with increased expression of endothelial adhesion molecules in margins of the chronic diabetic foot ulcers. Wound Repair Regen. 2005;13:248–54.
Karnasula VM. Management of ulcers in lymphoedematous limbs. Indian J Plast Surg. 2012;45:261–5.
Olszewski WL, Jamal S, Manokaran G, Pani S, Kumaraswami V, Kubicka U, et al. Bacteriologic studies of skin, tissue fluid, lymph, and lymph nodes in patients with filarial lymphedema. Am J Trop Med Hyg. 1997;57:7–15.
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Olszewski, W.L. (2016). Role of Bacteria in Pathogenesis of Lower Leg Ulcers. In: Khanna, A., Tiwary, S. (eds) Ulcers of the Lower Extremity. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2635-2_9
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DOI: https://doi.org/10.1007/978-81-322-2635-2_9
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