Basal Cell Carcinoma

  • Chintamani
  • Megha Tandon


Cutaneous carcinomas are classified into melanotic and non-melanotic cancers. Non-melanotic cutaneous carcinomas (NMCC) are the most common skin cancers worldwide and include squamous cell carcinoma (SCC) and basal cell carcinoma (BCC). BCC is the most common human cancer, accounting for approximately 75 % of all NMCCs, followed by squamous cell carcinoma (SCC), which represents 20 % of all cutaneous malignancies. BCC consists of plugs and clusters of basal cells, with various clinical manifestations in accordance with various morphological features, which to a certain extent correspond with the various histological types [1].


Basal Cell Carcinoma Zinc Chloride Nevoid Basal Cell Carcinoma Syndrome Mohs Micrographic Surgery Mohs Surgery 
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  1. 1.
    Gallagher RP, Hill GB, Bajdik CD, et al. Sunlight exposure, pigmentation factors, and risk of nonmelanocytic skin cancer: II. Squamous cell carcinoma. Arch Dermatol. 1995;131:164.CrossRefPubMedGoogle Scholar
  2. 2.
    Chintamani, Shankar M, Singhal V, Singh JP, Bansal A, Saxena S. Squamous cell carcinoma developing in the scar of Fournier’s gangrene – case report. BMC Cancer. 2004;27(4):16.CrossRefGoogle Scholar
  3. 3.
    Fonder MA, Lazarus GS, Cowan DA, Aronson-Cook B, Kohli AR, Mamelak AJ. Treating the chronic wound: a practical approach to the care of nonhealing wounds and wound care dressings. J Am Acad Dermatol. 2008;58:185–206.CrossRefPubMedGoogle Scholar
  4. 4.
    Voisard JJ, Lazareth I, Baviera E, Priollet P. Ulceres de jambe et cancer. A propos de 6 observations. J Mal Vasc. 2001;26:85–91.PubMedGoogle Scholar
  5. 5.
    Brash DE. UV mutagenic photoproducts in E coli and human cells: a molecular genetics perspective on human skin cancer. Photochem Photobiol. 1988;48:59.CrossRefPubMedGoogle Scholar
  6. 6.
    Mitchell DL, Nairn RS. The biology of the (6–4) photoproduct. Photochem Photobiol. 1989;49:805.CrossRefPubMedGoogle Scholar
  7. 7.
    Ananthaswamy HN, Pierceall WE. Molecular mechanisms of ultraviolet radiation carcinogenesis. Photochem Photobiol. 1990;52:1119.CrossRefPubMedGoogle Scholar
  8. 8.
    Brash DE, Ziegler A, Jonason A, et al. Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. J Invest Dermatol Symp Proc. 1996;1:136.Google Scholar
  9. 9.
    Black HS, deGruijl FR, Forbes D, et al. Photocarcinogenesis: an overview. J Photochem Photobiol B. 1997;40:29. Leffell DJ, Brash DE. Sunlight and skin cancer. Sci Am. 1996;275:52.CrossRefPubMedGoogle Scholar
  10. 10.
    Zanetti R, et al. The multicentre south European study: skin characteristics and sunburns in basal cell and squamous cell carcinomas of the skin. Br J Cancer. 1996;73:1440.CrossRefPubMedPubMedCentralGoogle Scholar
  11. 11.
    Ziegler A, Leffell DJ, Kunula S, et al. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proc Natl Acad Sci U S A. 1993;90:4216.CrossRefPubMedPubMedCentralGoogle Scholar
  12. 12.
    Hahn N, Woinbwski L, Miller U, Zimmer A. The patched signaling pathway in tumorigenesis and development: lessons from animal models. J Mol Med. 1999;77:459.CrossRefPubMedGoogle Scholar
  13. 13.
    Ping XL, Ratner D, Zhang H, et al. PTCH mutations in squamous cell carcinomas of the skin. J Invest Dermatol. 2001;116:614.CrossRefPubMedGoogle Scholar
  14. 14.
    Weninger W, et al. Differences in tumor microvessel density between squamous cell carcinomas and basal cell carcinomas may relate to their different biologic behavior. J Cutan Pathol. 1997;24:364.CrossRefPubMedGoogle Scholar
  15. 15.
    Miller SJ. Biology of basal cell carcinoma (part I). J Am Acad Dermatol. 1991;24:1.CrossRefPubMedGoogle Scholar
  16. 16.
    Robinson JK, Dahiya M. Basal cell carcinoma with pulmonary and lymph node metastasis causing death. Arch Dermatol. 2003;139:643.CrossRefPubMedGoogle Scholar
  17. 17.
    Niazi ZB, Lamberty BG. Perineural infiltration in basal cell carcinomas. Br J Plast Surg. 1993;46:156.CrossRefPubMedGoogle Scholar
  18. 18.
    Scherbenske JM, et al. A solitary nodule on the chest: fibroepithelioma of Pinkus. Arch Dermatol. 1990;126:955.CrossRefPubMedGoogle Scholar
  19. 19.
    Muller P, Roul S, Mahe A, Roudier M, Vaque D, Strobel M. Carcinomeepidermoide sur ulcere de jambeaux Antilles. Ann Dermatol Venereol. 2004;131:347–50.CrossRefPubMedGoogle Scholar
  20. 20.
    Combemale P, Bousquet M, Estival J, Dupin M, le groupe d’Angio-Dermatologie de la Societe Francaisede Dermatologie. Degenerescencecarcinomateuse des ulceres vasculaires de jambe: etude nationale retrospectivede 80 cas. Ann Dermatol Vénéréol. 2004;131:1S67.Google Scholar
  21. 21.
    Coulomb A, Agence Nationaled’Accreditation et d’Evaluation(ANAES). Recommandations pour lapratique clinique. Prise en charge ducarcinome basocellulaire de ladulte. Ann Dermatol Venereol. 2004;131:661–756.CrossRefPubMedGoogle Scholar
  22. 22.
    Holmkvist KA, Rogers GS, Dahl PR. Incidence of residual basal cell carcinoma in who appear tumor free after biopsy. J Am Acad Dermatol. 1999;41:600.PubMedGoogle Scholar
  23. 23.
    Evans GR, Williams JZ, Ainslie NB. Cutaneous nasal malignancies: is primary reconstruction safe? Head Neck. 1997;3:182.CrossRefGoogle Scholar
  24. 24.
    Kumar B, et al. A review of 24 cases of Mohs surgery and ophthalmic plastic reconstruction. Aust N Z J Ophthalmol. 1997;25:289.CrossRefPubMedGoogle Scholar
  25. 25.
    Wolf DJ, Zitelli JA. Surgical margins for basal cell carcinoma. Arch Dermatol. 1987;123:340.CrossRefPubMedGoogle Scholar
  26. 26.
    Leslie DF, Greenway HT. Mohs micrographic surgery for skin cancer. Australas J Dermatol. 1991;32:159.CrossRefPubMedGoogle Scholar
  27. 27.
    Rowe DE, Carroll RJ, Day Jr CL. Mohs surgery is the treatment of choice for recurrent (previously treated) basal cell carcinoma. J Dermatol Surg Oncol. 1989;15:424.CrossRefPubMedGoogle Scholar
  28. 28.
    Kopf AW, et al. Curettage-electrodesiccation treatment of basal cell carcinomas. Arch Dermatol. 1977;113:439.CrossRefPubMedGoogle Scholar
  29. 29.
    Goncalves JC. Fractional cryosurgery. A new technique for basal cell carcinoma of the eyelids and periorbital area. Dermatol Surg. 1997;23:475.CrossRefPubMedGoogle Scholar
  30. 30.
    Wilder RB, Kittelson JM, Shimm DS. Basal cell carcinoma treated with radiation therapy. Cancer. 1991;68:2134.CrossRefPubMedGoogle Scholar

Copyright information

© Springer India 2016

Authors and Affiliations

  1. 1.Department of SurgeryVMMC, Safdarjung HospitalNew DelhiIndia

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