Abstract
Ulcers of the foot have evolved as a subspecialty in itself. Though benign conditions comprise of the major causes, malignant ulcers are not at all a rare entity. Melanomas are defined as malignant neoplasms arising from the melanin-producing melanocytes of the skin (originally developed from the neural crests). Malignant melanoma is one of the most common malignant ulcers affecting the extremities in all age groups. Statistics from the Indian subcontinent is a scarcity, but in the United States, the annual incidence is close to 75,000 new cases per year with approximately 9000 deaths per year [1]. A surprising fact remains that females are mostly predisposed to melanomas of the extremities.
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References
Williams NS, Bulstrode CJK, O’Connell PR, editors. Bailey and love short practice of surgery. 26th ed. London: Arnold, A member of the Hodder Headline group; 2000.
Brunicardi CF, Andersen DK, Billiar TR, Dunn DL, Hunter JJ, Pollock RE. Schwartz’s text book of surgery. USA: McGraw-Hill Medical Publishing; 2005.
Jönsson G, et al. Gene expression profiling-based identification of molecular subtypes in stage IV melanomas with different clinical outcome. Clin Cancer Res. 2010;16:3356–67.
Traugott L. Amber, Hall L Bruce. The Washington manual of surgery. 6th ed. St Louis: Wolters Kluwer-Lippincott Williams and Wilkins; 2012.
Cuschieri A, Steele RJC, Moossa AR. Essential surgical practice, higher surgical training in general surgery. 4th ed. London/New York: Arnold; 2002.
Kadison AS, Morton DL. Immunotherapy of malignant melanoma. Surg Clin North Am. 2003;83(2):343–70.
Zeiser R, Schnitzler M, Andrlova H, Hellige T, Meiss F. Immunotherapy for malignant melanoma. Curr Stem Cell Res Ther. 2012;7(3):217–28.
Taber SW, Polk Jr HC. Mortality, major amputation rates, and leukopenia after isolated limb perfusion with phenylalanine mustard for the treatment of melanoma. Ann Surg Oncol. 1997;4:440–5.
Brobeil A, Berman C, Cruse CW, et al. Efficacy of hyperthermic isolated limb perfusion for extremity-confined recurrent melanoma. Ann Surg Oncol. 1998;5:376–83.
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Ganguly, S., Sarkar, D.K. (2016). Melanoma of the Extremity. In: Khanna, A., Tiwary, S. (eds) Ulcers of the Lower Extremity. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2635-2_23
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DOI: https://doi.org/10.1007/978-81-322-2635-2_23
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