Necrotizing Soft Tissue Infection

  • Ajay Kumar Khanna
  • Parameswaran Sundaran
  • Soumya Khanna


Necrotizing fasciitis (NF) better called as necrotizing soft tissue infection (NSTI) is infrequent but highly lethal infections. Necrotizing soft tissue infections (NSTIs) are fulminant infections of any layer of the soft tissue compartment associated with widespread necrosis and systemic toxicity. Delay in diagnosing and treating these infections increases the risk of mortality. Early and aggressive surgical debridement with support for the failing organs significantly improves the survival. These infections were first described by Jones in 1871, and at that time they were termed “hospital gangrene” [1]. According to Martin et al., necrotizing fasciitis (NF) is essentially a “severe inflammation of the muscle sheath that leads to necrosis of the subcutaneous tissue and adjacent fascia” that is difficult to diagnose early and even more difficult to manage effectively. Early clinical suspicion, appropriate antimicrobials, and surgery are key to improving survival. The problem is that it is difficult to diagnose as in one survey, the correct diagnosis was initially suspected in only 2 % of admissions [2, 3].


Hyperbaric Oxygen Necrotizing Fasciitis Streptococcal Infection Toxic Shock Syndrome Necrotizing Soft Tissue Infection 
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Copyright information

© Springer India 2016

Authors and Affiliations

  • Ajay Kumar Khanna
    • 1
  • Parameswaran Sundaran
    • 2
  • Soumya Khanna
    • 3
  1. 1.Department of General SurgeryInstitute of Medical Sciences, Banaras Hindu UniversityVaranasiIndia
  2. 2.Senior Consultant, NSM Cooperative CollegeKollamIndia
  3. 3.Department of AnatomyInstitute of Medical Sciences, Banaras Hindu UniversityVaranasiIndia

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