Necrotizing Soft Tissue Infection
Necrotizing fasciitis (NF) better called as necrotizing soft tissue infection (NSTI) is infrequent but highly lethal infections. Necrotizing soft tissue infections (NSTIs) are fulminant infections of any layer of the soft tissue compartment associated with widespread necrosis and systemic toxicity. Delay in diagnosing and treating these infections increases the risk of mortality. Early and aggressive surgical debridement with support for the failing organs significantly improves the survival. These infections were first described by Jones in 1871, and at that time they were termed “hospital gangrene” . According to Martin et al., necrotizing fasciitis (NF) is essentially a “severe inflammation of the muscle sheath that leads to necrosis of the subcutaneous tissue and adjacent fascia” that is difficult to diagnose early and even more difficult to manage effectively. Early clinical suspicion, appropriate antimicrobials, and surgery are key to improving survival. The problem is that it is difficult to diagnose as in one survey, the correct diagnosis was initially suspected in only 2 % of admissions [2, 3].
KeywordsHyperbaric Oxygen Necrotizing Fasciitis Streptococcal Infection Toxic Shock Syndrome Necrotizing Soft Tissue Infection
- 1.Jones J,. Surgical Memoirs of the War of the Rebellion: Investigation Upon the Nature, Causes and Treatment of Hospital Gangrene as Prevailed in the Confederate Armies 1861–1865. New York: US Sanitary Commission; 1871.Google Scholar
- 2.Martin A. Necrotising fasciitis – early recognition and treatment can minimise risk of fatalities. N Z Publ Health Rep. 1994;1:9–10.Google Scholar
- 34.Janecicius RV, Hann SE, Batt MD. Necrotising fasciitis. Surg Gynecol Obstet. 1982;154:97–102.Google Scholar
- 42.Escobar SJ, Slade HJB, Hunt TK, Cianci P. Adjuvant hyperbaric oxygen (HBO2) for necrotising fasciitis reduces mortality and amputation rate. Undersea Hyperb Med Soc. 2005;32:437–43.Google Scholar
- 43.Kalaivani V, Hiremath BV, Indumathi VA. Necrotising soft tissue infection – risk factors for mortality. J Clin Diagn Res. 2013;7:1662–5.Google Scholar