Auger Electron-Based Radionuclide Therapy
The focuses of this chapter are to describe the decay processes which result in Auger electron emission and the potential expected importance of therapy with targeted radiopharmaceutical agents radiolabeled with Auger-emitting radioisotopes. Although not yet matured to the point for accepted clinical utility, interest in the therapeutic application of radiopharmaceuticals radiolabeled with Auger-emitting radioisotopes has remained an important intellectual and experimental area because of the great potential utility of these radioisotopes. There are in fact only a few Auger-emitting radioisotopes which are expected—at least within our current understanding—to have any practical utility for clinical therapy. However, these radioisotopes are discussed because of their unique decay properties and potential usefulness. In addition, comments on the issues associated with the production and processing technology required to provide Auger emitters modeling approaches for Auger electron-emitting radioisotopes are also briefly described. Because of the very short path lengths in soft tissue, dosimetric issues are required to assess the usefulness of these radioisotopes for individual cell-targeted therapy for the treatment of cancer in subsequent radiolabeling and biological studies. It is important that sufficient levels of these radioisotopes can be produced and made available in sufficiently high specific activity and radiopurity for development of targeting agents to assess the biological effectiveness of such proposed therapy.
KeywordsAuger Electron Linear Energy Transfer Auger Therapy Auger Electron Spectrum Medical Internal Radiation Dose
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