Locoregional Radionuclide Therapy for Nonmelanoma Skin Cancer (NMSC)

  • F. F. (Russ) Knapp
  • Ashutosh Dash


The incidence of skin cancer continues to rapidly increase, especially in the Western world. Melanoma is the most dangerous because of its often undiagnosed presence and metastatic potential and can have a 5-year survival rate of only about 98 %, if detected early before the cancer has penetrated the skin. After metastasis to other organs, however, the survival rate can be as low as 15 %. About 90 % of nonmelanoma skin cancers (NMSC) are estimated to result directly from ultraviolet radiation from sun exposure and primarily consist of the common basal cell (BCC) and squamous cell carcinomas (SCC) which often result from actinic keratosis precancers. These cancers can usually be effectively eradicated by surgery and local radiation treatment. However, scarring and disfigurement, especially on the face, are major issues. A new method using topical application of beta-emitting radionuclides has been introduced as an attractive, inexpensive, and effective alternative.


Skin Cancer Basal Cell Carcinoma Natural Rubber Skin Patch Nonmelanoma Skin Cancer 
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Copyright information

© Springer India 2016

Authors and Affiliations

  • F. F. (Russ) Knapp
    • 1
  • Ashutosh Dash
    • 2
  1. 1.Nuclear Security and Isotope DivisionOak Ridge National LaboratoryOAK RIDGEUSA
  2. 2.Isotope Production and Applications DivisionBhabha Atomic Research CentreMumbaiIndia

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