Microbial Vesicles: From Ecosystem to Diseases

  • Shashank S. Kamble
  • Nancy Garg
  • Brijendra Kumar Tiwari
  • Lalit K. Singh
  • Neha Dhasmana
  • Yogendra Singh


The production of outer membrane vesicles (OMVs) is conserved in eukaryotes and prokaryotes. OMVs are double-layered structures with contents from outer membrane, periplasmic space, and even cytosol. Some of them have been shown to contain nucleic acids as well, which explains the specialized system for the packaging of these vesicles. OMVs mediate essential processes such as transport of nutrients, antigens, and virulence factors, etc., which help the microorganisms in communication as well as in killing of other microbial cells. The biogenesis of OMVs differs in bacteria and archaea. The archaeal OMV biogenesis is similar to eukaryotes involving ESCRT machinery, while in gram-negative bacteria, it occurs either due to broken OM-PG interaction or due to increased periplasmic pressure. OMVs containing antigens have been recently explored for use as vaccine which provides another dimension for its applications.


Outer Membrane Membrane Vesicle Anthrax Toxin Outer Membrane Vesicle Pseudomonas Quinolone Signal 



The authors wish to thank the Director of CSIR-Institute of Genomics and Integrative Biology (IGIB), Government of India for providing the necessary funds, and facilities. Authors are also thankful to Academy of Scientific and Innovative Research (AcSIR), New Delhi. SSK is a Senior Research Fellow supported by UGC, India. NG is a project assistant funded from BSC0123 (DRDO, India). BKT is a research associate supported by CSIR, India. LKS is a Senior Research Fellow supported by University Grant Commission, India. ND is a Shyama Prasad Mukherjee-Senior Research Fellow supported by CSIR, India. We highly acknowledge Neha Dubey and Dr. V. C. Kalia from CSIR-IGIB, Delhi, India, for inspiration and critical comments on the manuscript.


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Copyright information

© Springer India 2015

Authors and Affiliations

  • Shashank S. Kamble
    • 1
  • Nancy Garg
    • 1
  • Brijendra Kumar Tiwari
    • 1
  • Lalit K. Singh
    • 1
  • Neha Dhasmana
    • 1
  • Yogendra Singh
    • 2
  1. 1.Allergy and Infectious DiseasesCSIR-Institute of Genomics and Integrative BiologyDelhiIndia
  2. 2.Allergy and Infectious DiseasesCSIR-Institute of Genomics and Integrative BiologyDelhiIndia

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