Skip to main content
SpringerLink
Log in

Bioactive Carbohydrate: Dietary Fibers and Colorectal Cancer

  • Chapter
Probiotics and Bioactive Carbohydrates in Colon Cancer Management

Abstract

The health benefits of dietary fibers, namely, the insoluble and soluble fractions, against colorectal cancer are focused here. The role of food and occupational-originated environmental carcinogens or mutagens (heterocyclic amines, HCA, and polycyclic aromatic hydrocarbon, PAH) and the effects of dietary fibers against colorectal cancer (CRC) have recently gained ample interest. Epidemiological and clinical studies show that increasing the consumption of dietary fiber decreases the incidences of CRC. They act differently from drugs, and their effects could be categorized majorly into physiological and cellular or molecular mechanisms. The benefits accruing through the former include increase in intestinal viscosity, detoxification by binding the promutagens and mutagens, dilution and fecal bulking, pH maintenance, growth of favorable bacteria, formation of short-chain fatty acids (in particular, butyrate), and reduced transit time. The major pathway in cellular mechanism includes butyrate formation, which modulates the gene expression and assists in the elimination of damaged DNA. Immunomodulation by phase I and phase II enzymes, antitumor activity by induction of TNF-α and NK-cells, and antiproliferative activity are other cellular mechanisms that induce apoptosis and death of cells containing damaged DNA. Role of various dietary fibers and their fractions against CRC could prove the way for reducing the incidence of the carcinogenesis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • AACC (1995) Approved method of American association of cereal chemists. American Association of Cereal Chemists, St. Paul

    Google Scholar 

  • Abell GC, Cooke CM, Benett CN, Conlon MA, McOnst AL (2008) Phylotypes related to Ruminococcus bromii are abundant in the large bowel of humans and increase in response to a diet high in resistant starch. FEMS Microbiol Ecol 66(3):505–515

    Article  CAS  Google Scholar 

  • Angeli P, Wong F, Watson H, Gines P (2006) Hyponatremia in cirrhosis: results of a patient population survey. Hepatology 44(6):1535–1542

    Article  CAS  Google Scholar 

  • AOAC (1995) Official methods of analysis of the Association of Official Analystical Chemists , 16th edn. Horowitz W (ed). AOAC, Washington, DC, pp18–19

    Google Scholar 

  • Asp NG, Johansson CG, Hallmer H, Siljestroem M (1983) Rapid enzymatic assay of insoluble and soluble dietary fiber. J Agric Food Chem 31(3):476–482

    Article  CAS  Google Scholar 

  • Aune D, Chan DS, Lau R, Vieira R, Greenwood DC, Kampman E, Norat T (2011) Dietary fibre, whole grains, and risk of colorectal cancer: systematic review and dose–response meta-analysis of prospective studies. BMJ 343:d6617

    Article  Google Scholar 

  • Aune D, Norat T, Romundstad P, Vatten LJ (2013) Whole grain and refined grain consumption and the risk of type 2 diabetes: a systematic review and dose–response meta-analysis of cohort studies. Eur J Epidemiol 28(11):845–858

    Article  CAS  Google Scholar 

  • Baker MA, Dorris PA (1981) Effect of dehydration on hypothalamic control of evaporation in the cat. J Physiol 322:457–468

    Article  Google Scholar 

  • Baker D, Norris KH, Li BW (1979) Food fibre analysis: advances in methodology. In: Inglett GE, Falkehag SI (eds) Dietary fibers: chemistry and nutrition. Academic, London

    Google Scholar 

  • Bernardshaw S, Hetland G, Grinde B, Johnson E (2006) An extract of the mushroom Agaricus blazei Murill protects against lethal septicemia in a mouse model of fecal peritonitis. Shock 25(4):420–425

    Article  Google Scholar 

  • Beyer-Sehlmeyer G, Glei M, Hartmann E, Hughes R, Persin C, Böhm V et al (2003) Butyrate is only one of several growth inhibitors produced during gut flora-mediated fermentation of dietary fibre sources. Br J Nutr 90(6):1057–1070

    Article  CAS  Google Scholar 

  • Biondo PD, Goruk S, Ruth MR, O’Connell E, Field CJ (2008) Effect of CVT-E002 (COLD-fX) versus a ginsenoside extract on systemic and gut-associated immune function. Int Immunopharmacol 8(8):1134–1142

    Article  CAS  Google Scholar 

  • Böhmig GA, Krieger PM, Säemann MD, Wenhardt C, Pohanka E, Zlabinger GJ (1997) n-Butyrate downregulates the stimulatory function of peripheral blood-derived antigen-presenting cells: a potential mechanism for modulating T-cell responses by short-chain fatty acids. Immunology 92:234–243

    Article  Google Scholar 

  • Bosscher D, Breynaert A, Pieters L, Hermans N (2009) Food-based strategies to modulate the composition of the intestinal microbiota and their associated health effects. J Physiol Pharmacol 60(Suppl 6):S5–S11

    Google Scholar 

  • Burkitt DP, Walker ARP, Painter NS (1972) Effect of dietary fibre on stools and transit-times, and its role in the causation of disease. Lancet 300(7792):1408–1411

    Article  Google Scholar 

  • Bultman SJ (2014) Molecular pathways: gene–environment interactions regulating dietary fiber Induction of proliferation and apoptosis via butyrate for cancer prevention. Clin Cancer Res 20(4):799–803

    Article  CAS  Google Scholar 

  • Caldwell EF, Nelsen TC (1999) Development of an analytical reference standard for total, insoluble, and soluble dietary fiber. Cereal Foods World 44(5):360–362

    Google Scholar 

  • Chan PA, Duraisamy S, Miller PJ, Newell JA, McBride C, Bond JP et al (2007) Interpreting missense variants: comparing computational methods in human disease genes CDKN2A, MLH1, MSH2, MECP2, and tyrosinase (TYR). Hum Mutat 28(7):683–693

    Article  CAS  Google Scholar 

  • Chawla R, Patil GR (2010) Soluble dietary fiber. Comp Rev Food Sci Food Saf 9(2):178–196

    Article  CAS  Google Scholar 

  • Chen HM, Yu YN, Wang JL, Lin YW, Kong X, Yang CQ et al (2013) Decreased dietary fiber intake and structural alteration of gut microbiota in patients with advanced colorectal adenoma. Am J Clin Nutr 97(5):1044–1052

    Article  CAS  Google Scholar 

  • Cheung NKV, Modak S, Vickers A, Knuckles B (2002) Orally administered beta-glucans enhance anti-tumor effects of monoclonal antibodies. Cancer Immunol Immunother 51(10):557–564

    CAS  Google Scholar 

  • Christophersen CT, Petersen A, Licht TR, Conlon MA (2013) Xylo-oligosaccharides and inulin affect genotoxicity and bacterial populations differently in a human colonic simulator challenged with soy protein. Nutrients 5(9):3740–3756

    Article  CAS  Google Scholar 

  • Comalada M, Ballester I, Bailon E, Sierra S, Xaus J, Galvez J et al (2006) Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure-activity relationship. Biochem Pharmacol 72(8):1010–1021

    Article  CAS  Google Scholar 

  • Coudray C, Demigné C, Rayssiguier Y (2003) Effects of dietary fibers on magnesium absorption in animals and humans. J Nutr 133(1):1–4

    CAS  Google Scholar 

  • Cousin FJ, Jouan-Lanhouet S, Dimanche-Boitrel MT, Corcos L, Jan G (2012) Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells. PLoS One 7(3), e31892

    Article  CAS  Google Scholar 

  • Cummings JH, Macfarlane GT (1991) The control and consequences of bacterial fermentation in the human colon. J Appl Bacteriol 70(6):443–459

    Article  CAS  Google Scholar 

  • Davis CD, Milner JA (2009) Gastrointestinal microflora, food components and colon cancer prevention. J Nutr Biochem 20(10):743–752

    Article  CAS  Google Scholar 

  • De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S et al (2010) Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci U S A 107(33):14691–14696

    Article  Google Scholar 

  • Delzenne NM, Neyrinck AM, Cani PD (2011) Modulation of the gut microbiota by nutrients with prebiotic properties: consequences for host health in the context of obesity and metabolic syndrome. Microb Cell Fact 10(Suppl 1):S10

    Article  Google Scholar 

  • Duckworth J, Godden W (1941) The lability of skeletal magnesium reserves. The influence of rates of bone growth. Biochem J 35(7):816–823

    Article  CAS  Google Scholar 

  • El-Zoghbi M, Sitohy MZ (2001) Mineral absorption by albino rats as affected by some types of dietary pectins with different degrees of esterification. Nahrung 45(2):114–117

    Article  CAS  Google Scholar 

  • Flint HJ, Duncan SH, Scott KP, Louis P (2007) Interactions and competition within the microbial community of the human colon: links between diet and health. Environ Microbiol 9(5):1101–1111

    Article  CAS  Google Scholar 

  • Fujii T, Maeda H, Suzuki F, Ishida N (1978) Isolation and characterization of a new antitumor polysaccharide, KS-2, extracted from culture mycelia of Lentinus edodes. J Antibiot 31(11):1079–1090

    Article  CAS  Google Scholar 

  • Furda I (1981) Simultaneous analysis of soluble and insoluble dietary fiber. In: James WPT, Theander O (eds) The analysis of fiber in food. Marcel Dekker, New York

    Google Scholar 

  • Furda I, Gengler SC, Johnson RR, Magnuson JS, Smith DE (1979) Complete carbohydrate analysis-sugars, starch, and total dietary fiber in plant residues and food products. In: 93rd annual meeting of the AOAC, Washington, DC

    Google Scholar 

  • Gan L, Zhang SH, Yang XL, Xu HB (2004) Immunomodulation and antitumor activity by a polysaccharide–protein complex from Lycium barbarum. Int Immunopharmacol 4(4):563–569

    Article  CAS  Google Scholar 

  • Garrett WS, Gordon JI, Glimcher LH (2010) Homeostasis and inflammation in the intestine. Cell 140(6):859–870

    Article  CAS  Google Scholar 

  • Gibson GR, Beatty ER, Wang X, Cummings JH (1995) Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108(4):975–982

    Article  CAS  Google Scholar 

  • Greger JL (1999) Nondigestible carbohydrates and mineral bioavailability. J Nutr 129(7):1434S–1435S

    CAS  Google Scholar 

  • Hanaue H, Tokuda Y, Machimura T, Kamijoh A, Kondo Y, Ogoshi K et al (1988) Effects of oral lentinan on T-cell subsets in peripheral venous blood. Clin Ther 11(5):614–622

    Google Scholar 

  • Hara H, Nagata M, Ohta A, Kasai T (1996) Increases in calcium absorption with ingestion of soluble dietary fibre, guar-gum hydrolysate, depend on the caecum in partially nephrectomized and normal rats. Br J Nutr 76(5):773–784

    Article  CAS  Google Scholar 

  • Hayashi A, Gillen AC, Lott JR (2000) Effects of daily oral administration of quercetin chalcone and modified citrus pectin on implanted colon-25 tumor growth in Balb-c mice. Altern Med Rev 5(6):546–552

    CAS  Google Scholar 

  • Hayashi K, Nakano T, Hashimoto M, Kanekiyo K, Hayashi T (2008) Defensive effects of a fucoidan from brown alga Undaria pinnatifida against herpes simplex virus infection. Int Immunopharmacol 8(1):109–116

    Article  CAS  Google Scholar 

  • Heckman MM, Lane SA (1981) Comparison of dietary fiber methods for foods. J Assoc Off Anal Chem 64(6):1339–1343

    CAS  Google Scholar 

  • Hipsley EH (1953) Dietary fibre and pregnancy toxaemia. Br Med J 2(4833):420–422

    Article  CAS  Google Scholar 

  • Hishida I, Nanba H, Kuroda H (1988) Antitumor activity exhibited by orally administered extract from fruit body of Grifola frondosa (maitake). Chem Pharm Bull 36(5):1819–1827

    Article  CAS  Google Scholar 

  • Ho JCK, Konerding MA, Gaumann A, Groth M, Liu WK (2004) Fungal polysaccharopeptide inhibits tumor angiogenesis and tumor growth in mice. Life Sci 75(11):1343–1356

    Article  CAS  Google Scholar 

  • Hong HJ, Hutchings MI, Neu JM, Wright GD, Paget MS, Buttner MJ (2004) Characterization of an inducible vancomycin resistance system in Streptomyces coelicolor reveals a novel gene (vanK) required for drug resistance. Mol Microbiol 52(4):1107–1121

    Article  CAS  Google Scholar 

  • Hyun JH, Kim SC, Kang JI, Kim MK, Boo HJ, Kwon JM et al (2009) Apoptosis inducing activity of fucoidan in HCT-15 colon carcinoma cells. Biol Pharm Bull 32(10):1760–1764

    Article  CAS  Google Scholar 

  • Irhimeh MR, Fitton JH, Lowenthal RM, Kongtawelert P (2005) A quantitative method to detect fucoidan in human plasma using a novel antibody. Methods Find Exp Clin Pharmacol 27(10):705–710

    Article  CAS  Google Scholar 

  • Irhimeh MR, Fitton JH, Lowenthal RM (2007) Fucoidan ingestion increases the expression of CXCR4 on human CD34+ cells. Exp Hematol 35(6):989–994

    Article  CAS  Google Scholar 

  • Ishizuka S, Tanaka S, Xu H, Hara H (2004) Fermentable dietary fiber potentiates the localization of immune cells in the rat large intestinal crypts. Exp Biol Med (Maywood) 229(9):876–884

    CAS  Google Scholar 

  • Ismail-Beigi F, Reinhold JG, Faraji B, Abadi P (1977) Effects of cellulose added to diets of low and high fiber content upon the metabolism of calcium, magnesium, zinc and phosphorus by man. J Nutr 107(4):510–518

    CAS  Google Scholar 

  • Ito H, Shimura K, Itoh H, Kawade M (1997) Antitumor effects of a new polysaccharide-protein complex (ATOM) prepared from Agaricus blazei (Iwade strain 101) “Himematsutake” and its mechanisms in tumor-bearing mice. Anticancer Res 17(1A):277–284

    CAS  Google Scholar 

  • Jacobs DM, Gaudier E, Duynhoven JV, Vaughan EE (2009) Non-digestible food ingredients, colonic microbiota and the impact on gut health and immunity: a role for metabolomics. Curr Drug Metab 10(1):41–54

    Article  CAS  Google Scholar 

  • Jones JM (2014) CODEX-aligned dietary fiber definitions help to bridge the ‘fiber gap’. Nutr J 13(1):34

    Article  CAS  Google Scholar 

  • Kim EJ, Park SY, Lee JY, Park JH (2010) Fucoidan present in brown algae induces apoptosis of human colon cancer cells. BMC Gastroenterol 10(1):96

    Article  CAS  Google Scholar 

  • Kirmaz C, Bayrak P, Yilmaz O, Yuksel H (2005) Effects of glucan treatment on the Th1/Th2 balance in patients with allergic rhinitis: a double-blind placebo-controlled study. Eur Cytokine Netw 16(2):128–134

    CAS  Google Scholar 

  • Kobayashi H, Yoshida R, Kanada Y, Fukuda Y, Yagyu T, Inagaki K et al (2005) Suppressing effects of daily oral supplementation of beta-glucan extracted from Agaricus blazei Murill on spontaneous and peritoneal disseminated metastasis in mouse model. J Cancer Res Clin Oncol 131(8):527–538

    Article  CAS  Google Scholar 

  • Koetzner L, Grove G, Boulet J, Jacoby HI (2010) Plant-derived polysaccharide supplements inhibit dextran sulfate sodium-induced colitis in the rat. Dig Dis Sci 55(5):1278–1285

    Article  CAS  Google Scholar 

  • Koray M, Ak G, Kürklü E, Tanyeri H, Aydin F, Oguz FS et al (2009) The effect of beta-glucan on recurrent aphthous stomatitis. J Altern Complement Med 15(2):111–112

    Article  Google Scholar 

  • Kubo K, Nanba H (1997) Anti-hyperliposis effect of maitake fruit body (Grifola frondosa). I Biol Pharm Bull 20(7):781–785

    Article  CAS  Google Scholar 

  • Kundu JK, Surh YJ (2012) Emerging avenues linking inflammation and cancer. Free Radic Biol Med 52(9):2013–2037

    Article  CAS  Google Scholar 

  • Kurashige S, Akuzawa Y, Endo F (1997) Effects of Lentinus edodes, Grifola frondosa and Pleurotus ostreatus administration on cancer outbreak, and activities of macrophages and lymphocytes in mice treated with a carcinogen, N-butyl-N-butanolnitrosoamine. Immunopharmacol Immunotoxicol 19(2):175–183

    Article  CAS  Google Scholar 

  • Lattimer JM, Haub MD (2010) Effects of dietary fiber and its components on metabolic health. Nutrients 2(12):1266–1289

    Article  CAS  Google Scholar 

  • Le Leu RK, Hu Y, Brown IL, Woodman RJ, Young GP (2010) Synbiotic intervention of Bifidobacterium lactis and resistant starch protects against colorectal cancer development in rats. Carcinogenesis 31(2):246–251

    Article  CAS  Google Scholar 

  • Lee J, Renita M, Fioritto RJ, St. Martin SK, Schwartz SJ, Vodovotz Y (2004) Isoflavone characterization and antioxidant activity of Ohio soybeans. J Agri Food Chem 52(9):2647–2651

    Article  CAS  Google Scholar 

  • Lewis SJ, Heaton KW (1997) Stool form scale as a useful guide to intestinal transit time. Scand J Gastroenterol 32(9):920–924

    Article  CAS  Google Scholar 

  • Lim BO, Lee SH, Park DK, Choue RW (2003) Effect of dietary pectin on the production of immunoglobulins and cytokines by mesenteric lymph node lymphocytes in mouse colitis induced with dextran sulfate sodium. Biosci Biotechnol Biochem 67(8):1706–1712

    Article  CAS  Google Scholar 

  • Lim BO, Lee CJ, Kim JD (2004) Study on immunoregulatory function of dietary fiber. Food Ind Nutr 9:26–30

    Google Scholar 

  • Lin JY, Chen ML, Chiang BL, Lin BF (2006) Ganoderma tsugae supplementation alleviates bronchoalveolar inflammation in an airway sensitization and challenge mouse model. Int Immunopharmacol 6:241–251

    Article  CAS  Google Scholar 

  • Lin KT, Wang YW, Chen CT, Ho CM, Su WH, Jou YS (2012) HDAC inhibitors augmented cell migration and metastasis through induction of PKCs leading to identification of low toxicity modalities for combination cancer therapy. Clin Cancer Res 18(17):4691–4701

    Article  CAS  Google Scholar 

  • Lu H, Kyo E, Uesaka T, Katoh O, Watanabe H (2002) Prevention of development of N, N′-dimethylhydrazine-induced colon tumors by a water-soluble extract from cultured medium of Ganoderma lucidum (Rei-shi) mycelia in male ICR mice. Int J Mol Med 9(2):113–117

    Google Scholar 

  • Lupton JR (2004) Microbial degradation products influence colon cancer risk: the butyrate controversy. J Nutr 134(2):479–482

    CAS  Google Scholar 

  • Luster AD, Alon R, von Andrian UH (2005) Immune cell migration in inflammation: present and future therapeutic targets. Nat Immunol 6(12):1182–1190

    Article  CAS  Google Scholar 

  • Macfarlane GT, Steed H, Macfarlane S (2008) Bacterial metabolism and health-related effects of galacto-oligosaccharides and other prebiotics. J Appl Microbiol 104(2):305–344

    CAS  Google Scholar 

  • Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D et al (2009) Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461(7268):1282–1286

    Article  CAS  Google Scholar 

  • Matsumoto S, Nagaoka M, Hara T, Kimura-Takagi I, Mistuyama K, Ueyama S (2004) Fucoidan derived from Cladosiphon okamuranus Tokida ameliorates murine chronic colitis through the down‐regulation of interleukin‐6 production on colonic epithelial cells. Clin Exp Immunol 136(3):432–439

    Article  CAS  Google Scholar 

  • Mazmanian SK, Kasper DL (2006) The love-hate relationship between bacterial polysaccharides and the host immune system. Nat Rev Immunol 6(11):849–858

    Article  CAS  Google Scholar 

  • McBurney MI, Thompson LU (1990) Fermentative characteristics of cereal brans and vegetable fibers. Nutr Cancer 13(4):271–280

    Article  CAS  Google Scholar 

  • McCance EA, Laurence ED (1929) The carbohydrate content of foods. Med Res Counc Spec Rep Ser 135:73

    Google Scholar 

  • McElhaney JE, Goel V, Toane B, Hooten J, Shan JJ (2006) Efficacy of COLD-fX in the prevention of respiratory symptoms in community-dwelling adults: a randomized, double-blinded, placebo controlled trial. J Altern Complement Med 12(2):153–157

    Article  Google Scholar 

  • Mitomi T, Tsuchiya S, Iijima N, Aso K, Suzuki K, Nishiyama K et al (1992) Randomized, controlled study on adjuvant immunochemotherapy with PSK in curatively resected colorectal cancer. The Cooperative Study Group of Surgical Adjuvant Immunochemotherapy for Cancer of Colon and Rectum (Kanagawa). Dis Colon Rectum 35(2):123–130

    Article  CAS  Google Scholar 

  • Modak S, Koehne G, Vickers A, O’Reilly RJ, Cheung NKV (2005) Rituximab therapy of lymphoma is enhanced by orally administered (1 → 3), (1 → 4)-D-beta-glucan. Leuk Res 29(6):679–683

    Article  CAS  Google Scholar 

  • Murakawa K, Fukunaga K, Tanouchi M, Hosokawa M, Hossain Z, Takahashi K (2007) Therapy of myeloma in vivo using marine phospholipid in combination with Agaricus blazei Murill as an immune respond activator. J Oleo Sci 56(4):179–188

    Article  CAS  Google Scholar 

  • Murphy EA, Davis JM, Brown AS, Carmichael MD, Carson JA, Van Rooijen N et al (2008) Benefits of oat β-glucan on respiratory infection following exercise stress: role of lung macrophages. Am J Physiol Regul Integr Comp Physiol 294(5):R1593–R1599

    Article  CAS  Google Scholar 

  • Naito Y, Takagi T, Katada K, Uchiyama K, Kuroda M, Kokura S et al (2006) Partially hydrolyzed guar gum down-regulates colonic inflammatory response in dextran sulfate sodium-induced colitis in mice. J Nutr Biochem 17(6):402–409

    Article  CAS  Google Scholar 

  • Nanba H, Mori K, Toyomasu T, Kuroda H (1987) Antitumor action of shiitake (Lentinus edodes) fruit bodies orally administered to mice. Chem Pharm Bull 35(6):2453–2458

    Article  CAS  Google Scholar 

  • Nangia-Makker P, Hogan V, Honjo Y, Baccarini S, Tait L, Bresalier R, Raz A (2002) Inhibition of human cancer cell growth and metastasis in nude mice by oral intake of modified citrus pectin. J Natl Cancer Inst 94(24):1854–1862

    Article  CAS  Google Scholar 

  • Nantz MP, Percival SS, Painter AR, Parket E, McGill CR (2001) Evaluation of arabinogalactan’s effect on human immunity. FASEB J 15(4):A633

    Google Scholar 

  • Neyrinck AM, Mouson A, Delzenne NM (2007) Dietary supplementation with laminarin, a fermentable marine beta (1 → 3) glucan, protects against hepatotoxicity induced by LPS in rat by modulating immune response in the hepatic tissue. Int Immunopharmacol 7(12):1497–1506

    Article  CAS  Google Scholar 

  • Nishiyama C, Nagai T, Yano T (1992) Effects of pH on the in vitro sorption of mutagens to dietary fibers. Biosci Biotechnol Biochem 56(7):1100–1103

    Article  CAS  Google Scholar 

  • Oh GS, Lee MS, Pae HO, Kwon J, Lee SS, Jeong JG et al (2006) Effects of oral administration of Phellinus linteus on the production of Th1- and Th2-type cytokines in mice. Immunopharmacol Immunotoxicol 28(2):281–293

    Article  Google Scholar 

  • Ohkami H, Tazawa K, Yamashita I, Shimizu T, Murai K, Kobashi K, Fujimaki M (1995) Effects of apple pectin on fecal bacterial enzymes in azoxymethane-induced rat colon carcinogenesis. Jpn J Cancer Res 86(6):523–529

    Article  CAS  Google Scholar 

  • Oltmer S, Engelhardt WV (1994) Absorption of short-chain fatty acids from the in-situ-perfused caecum and colon of the guinea pig. Scand J Gastroenterol 29(11):1009–1016

    Article  CAS  Google Scholar 

  • Painter NS (1975) Diverticular disease of the colon, a 20th century problem. Clin Gastroenterol 4(1):3–21

    CAS  Google Scholar 

  • Paolillo R, Carratelli CR, Sorrentino S, Mazzola N, Rizzo A (2009) Immunomodulatory effects of Lactobacillus plantarum on human colon cancer cells. Int Immunopharmacol 9(11):1265–1271

    Article  CAS  Google Scholar 

  • Perrin S, Warchol M, Grill JP, Schneider F (2001) Fermentations of fructo‐oligosaccharides and their components by Bifidobacterium infantis ATCC 15697 on batch culture in semi‐synthetic medium. J Appl Microbiol 90(6):859–865

    Article  CAS  Google Scholar 

  • Pienta KJ, Nailk H, Akhtar A, Yamazaki K, Replogle TS, Lehr J et al (1995) Inhibition of spontaneous metastasis in a rat prostate cancer model by oral administration of modified citrus pectin. J Natl Cancer Inst 87(5):348–353

    Article  CAS  Google Scholar 

  • Prescha A, Krzysik M, Zabłocka-Słowińska K, Grajeta H (2014) Effects of exposure to dietary chromium on tissue mineral contents in rats fed diets with fiber. Biol Trace Elem Res 159(1–3):325–331

    Article  CAS  Google Scholar 

  • Prosky L, Asp N-G, Furda I, DeVries JW, Schweizer TF, Harland BF (1985) Determination of total dietary fiber in foods and food products: collaborative study. J Assoc Off Anal Chem 68:677–679

    CAS  Google Scholar 

  • Qu H, Madl RL, Takemoto DJ, Baybutt RC, Wang W (2005) Lignans are involved in the antitumor activity of wheat bran in colon cancer SW480 cells. J Nutr 5(3):598–602

    Google Scholar 

  • Raman M, Doble M (2014) Physicochemical and structural characterisation of marine algae Kappaphycus alvarezii and the ability of its dietary fibres to bind mutagenic amines. J Appl Psychol 26(5):2183–2191

    CAS  Google Scholar 

  • Raman M, Doble M (2015) Physicochemical characterization of wheat bran and Kappaphycus alvarezii dietary fibres and their ability to bind mutagens, PhIP, Trp-P-2, AαC and BαP. LWT Food Sci Tech 63(1):169–176

    Article  CAS  Google Scholar 

  • Raman M, Devi V, Doble M (2015) Biocompatible ι-carrageenan-γ-maghemite nanocomposite for biomedical applications–synthesis, characterization and in vitro anticancer efficacy. J Nanobiotechnol 13(1):18

    Article  CAS  Google Scholar 

  • Rechkemmer G, Rönnau K, Engelhardt WV (1988) Fermentation of polysaccharides and absorption of short chain fatty acids in the mammalian hindgut. Comp Biochem Physiol A Comp Physiol 90(4):563–568

    Article  CAS  Google Scholar 

  • Rice PJ, Lockhart BE, Barker LA, Adams EL, Ensley HE, Williams DL (2004) Pharmacokinetics of fungal (1–3)-b-D-glucans following intravenous administration in rats. Int Immunopharmacol 4:1209–1215

    Article  CAS  Google Scholar 

  • Rice PJ, Adams EL, Ozment-Skelton T, Gonzalez AJ, Goldman MP, Lockhart BE, Barker LA, Breuel KF, Deponti WK, Kalbfleisch JH, Ensley HE, Brown GD, Gordon S, Williams DL (2005) Oral delivery and gastrointestinal absorption of soluble glucans stimulate increased resistance to infectious challenge. J Pharmacol Exp Ther 314(3):1079–1086

    Article  CAS  Google Scholar 

  • Sakurai MH, Matsumoto T, Kiyohara H, Yamada H (1996) Detection and tissue distribution of anti-ulcer pectic polysaccharides from Bupleurum falcatum by polyclonal antibody. Planta Med 62(4):341–346

    Article  CAS  Google Scholar 

  • Sakurai MH, Marsumoto T, Kiyohara H, Yamada H (1999) B-cell proliferation activity of pectic polysaccharide from a medicinal herb, the roots of Bupleurum falcatum L. and its structural requirement. Immunology 97(3):540–547

    Article  CAS  Google Scholar 

  • Salzman NH (2011) Microbiota-immune system interaction: an uneasy alliance. Curr Opin Microbiol 14:99–105

    Article  Google Scholar 

  • Santarelli RL, Pierre F, Corpet DE (2008) Processed meat and colorectal cancer: a review of epidemiologic and experimental evidence. Nutri Cancer 60(2):131–144

    Article  CAS  Google Scholar 

  • Schweizer TF, Wursch P (1979) Analysis of dietary fibre. J Sci Food Agric 30:613–619

    Article  CAS  Google Scholar 

  • Segain JP, De La Blétiere DR, Bourreille A, Leray V, Gervois N, Rosales C et al (2000) Butyrate inhibits inflammatory responses through NF-κB inhibition: implications for Crohn’s disease. Gut 47:397–403

    Article  CAS  Google Scholar 

  • Shimada T, Fujii-Kuriyama Y (2005) Metabolic activation of polycyclic aromatic hydrocarbons to carcinogens by cytochromes P450 1A1 and 1B1. Cancer Sci 95(1):1–6

    Article  Google Scholar 

  • Sjödin PB, Nyman ME, Nilsson L, Asp N-GL, Jägerstad MI (1985) Binding of 14C-labeled food mutagens (IQ, MeIQ, MeIQx) by dietary fiber in vitro. J Food Sci 50(6):1680–1684

    Article  Google Scholar 

  • Smith EA, Macfarlane GT (1996) Enumeration of human colonic bacteria producing phenolic and indolic compounds: effects of pH, carbohydrate availability and retention time on dissimilatory aromatic amino acid metabolism. J Appl Bacteriol 81(3):288–302

    Article  CAS  Google Scholar 

  • Southgate DAT (1978) Has dietary fibre a role in prevention and treatment of obesity? Bibl Nutr Dieta 26:70–76

    Google Scholar 

  • Sun Y, Zhou X (2014) Purification, initial characterization and immune activities of polysaccharides from the fungus, Polyporus umbellatus. Food Sci Human Wellness 3(2):73–78

    Article  Google Scholar 

  • Suzuki I, Sakurai T, Hashimoto K (1991) Effect of intraperitoneally administered beta-1,3-glucan, SSG, obtained from Sclerotinia sclerotiorum IFO 9395 on the functions of murine alveolar macrophages. Chem Pharm Bull 39(1):214–217

    Article  Google Scholar 

  • Takimoto H, Wakita D, Kawaguchi K, Kumazawa Y (2004) Potentiation of cytotoxic activity in naïve and tumor-bearing mice by oral administration of hot-water extracts from Agaricus brazei fruiting bodies. Biol Pharm Bull 27(3):404–406

    Article  CAS  Google Scholar 

  • Tazoe H, Otomo Y, Karaki SI, Kato I, Fukami Y, Terasaki M, Kuwahara A (2009) Expression of short-chain fatty acid receptor GPR41 in the human colon. Biomed Res 30(3):149–156

    Article  CAS  Google Scholar 

  • Teas J, Harbison ML, Gelman RS (1984) Dietary seaweed (Laminaria) and mammary carcinogenesis in rats. Cancer Res 44(7):2758–2761

    CAS  Google Scholar 

  • Trowell H, Southgate DT, Wolever TS, Leeds A, Gassull M, Jenkins DA (1976) Dietary fibre redefined. Lancet 307(7966):967

    Article  Google Scholar 

  • Tsukada C, Yokohama H, Miyaji C, Ishimoto Y, Kawamura H, Abo T (2003) Immunopotentiation of intraepithelial lymphocytesin the intestine by oral administration of β-glucan. Cell Immunol 221:1–5

    Article  CAS  Google Scholar 

  • Turner ND, Lupton JR (2011) Dietary fiber. Adv Nutr 2(2):151–152

    Article  Google Scholar 

  • Udani JK, Singh BB, Barrett ML, Singh VJ (2009) Evaluation of mangosteen juice blend on biomarkers of inflammation in obese subjects: a pilot,dose finding study. Nutr J 8:48

    Article  CAS  Google Scholar 

  • Van Der Kamp JW, Jone J, McCleary B, Topping DJ (2010) Dietary fibre: new frontiers for food and health. Wageningen Academic Publishers, Wageningen

    Book  Google Scholar 

  • Vetvicka V, Vashishta A, Saraswat-Ohri S, Vetvickova J (2008) Immunological effects of yeast-and mushroomderived β-glucans. J Med Food 11(4):615–622

    Article  CAS  Google Scholar 

  • Vijay-Kumar M, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S et al (2010) Metabolic syndrome and altered gut microbiota in mice lacking Toll-like receptor 5. Science 328(5975):228–231

    Article  CAS  Google Scholar 

  • Vinolo M, Rodrigues H, Hatanaka E, Hebeda C, Farsky S, Curi R (2009) Short chain fatty acids stimulate the migration of neutrophils to inflammatory sites. Clin Sci 117:331–338

    Article  CAS  Google Scholar 

  • Vinolo MA, Ferguson GJ, Kulkarni S, Damoulakis G, Anderson K, Bohlooly-Y M et al (2011) SCFAs induce mouse neutrophil chemotaxis through the GPR43 receptor. PLoS One 6(6), e21205

    Article  CAS  Google Scholar 

  • Waldecker M, Kautenburger T, Daumann H, Busch C, Schrenk D (2008) Inhibition of histone-deacetylase activity by short-chain fatty acids and some polyphenol metabolites formed in the colon. J Nutr Biochem 19(9):587–593

    Article  CAS  Google Scholar 

  • Watanabe K, Reddy BS, Weisburger JH, Kritchevsky D (1979) Effect of dietary alfalfa, pectin, and wheat bran on azoxymethane-or methylnitrosourea-induced colon carcinogenesis in F344 rats. J Natl Cancer Inst 63(1):141–145

    CAS  Google Scholar 

  • Yamada H, Kiyohara H, Matsumoto T (2003) Recent studies on possible functions of bioactive pectins and pectic polysaccharides from medicinal herbs on health care. In: Advances in pectin and pectinase research. Springer, Dordrecht, pp 481–490

    Chapter  Google Scholar 

  • Yuan H, Song J, Li X, Li N, Dai J (2006) Immunomodulation and antitumor activity of κ-carrageenan oligosaccharides. Cancer Lett 243(2):228–234

    Article  CAS  Google Scholar 

  • Yuminamochi E, Koike T, Takeda K, Horiuchi I, Okumura K (2007) Interleukin-12- and interferon-gamma-mediated natural killer cell activation by Agaricus blazei Murill. Immunology 121(2):197–206

    Article  CAS  Google Scholar 

  • Yun CH, Estrada A, Kessel A, Park BC, Laarveld B (2003) Beta-glucan, extracted from oat, enhances disease resistance against bacterial and parasitic infections. FEMS Immunol Med Microbiol 35(1):67–75

    Article  CAS  Google Scholar 

  • Zapolska-Downar D, Naruszewicz M (2009) Propionate reduces the cytokine-induced VCAM-1 and ICAM-1 expression by inhibiting nuclear factor-kappa B (NF-kappaB) activation. J Physiol Pharmacol 60(2):123–131

    CAS  Google Scholar 

  • Zhu Y, Luo TM, Jobin C, Young HA (2011) Gut microbiota and probiotics in colon tumorigenesis. Cancer Lett 309(2):119–127

    Article  CAS  Google Scholar 

  • Zimmerman MA, Singh N, Martin PM, Thangaraju M, Ganapathy V, Waller JL et al (2012) Butyrate suppresses colonic inflammation through HDAC1-dependent Fas upregulation and Fas-mediated apoptosis of T cells. Am J Physiol Gastrointest Liver Physiol 302(12):G1405–G1415

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Bioengineering and Drug Design Lab Department of Biotechnology, Indian Institute of Technology Madras, Chennai, TN, India

    Maya Raman & Mukesh Doble

  2. Department of Biotechnology, Christ College, Saurashtra University, Rajkot, Gujarat, India

    Padma Ambalam

Authors
  1. Maya Raman
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Padma Ambalam
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mukesh Doble
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2016 Springer India

About this chapter

Cite this chapter

Raman, M., Ambalam, P., Doble, M. (2016). Bioactive Carbohydrate: Dietary Fibers and Colorectal Cancer. In: Probiotics and Bioactive Carbohydrates in Colon Cancer Management. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2586-7_3

Download citation

Publish with us

Policies and ethics

Search

Navigation