Malignant Tumours of the Paranasal Sinuses and Skull Base

  • Oshri Wasserzug
  • Leonor Leider-Trejo
  • Dan M. Fliss
  • Ziv Gil
Part of the Head and Neck Cancer Clinics book series (HNCC)


Malignant tumours of the paranasal sinuses and skull base are relatively rare (~3 % of all malignant tumours of the head and neck) [1]. The salient features of such tumours are male predominance, increased incidence among Caucasians, and an age of over 50 years of most of the patients at the time of diagnosis [2]. Tumours located in the anterior skull base may be of epithelial, neuronal or mesenchymal origin. Lymphomas and plasmocytomas are relatively rare in this area.


Nasal Cavity Skull Base Paranasal Sinus Maxillary Sinus Adenoid Cystic Carcinoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 1.
    Cantu G, Bimbi G, Miceli R, et al. Lymph node metastases in malignant tumors of the paranasal sinuses: Prognostic value and treatment. Arch Otolaryngol Head Neck Surg 2008;134:170–7.PubMedCrossRefGoogle Scholar
  2. 2.
    Hanna EY. Comprehensive management of skull base tumors. Informa Healthcare 2009.Google Scholar
  3. 3.
    DeMonte F, Ginsberg LE, Clayman GL. Primary malignant tumors of the sphenoidal sinus. Neurosurgery 2000;46:1084–91; discussion 91–2.PubMedCrossRefGoogle Scholar
  4. 4.
    Keane WM, Atkins JP, Jr, Wetmore R, et al. Epidemiology of head and neck cancer. Laryngoscope 1981;91:2037–45.PubMedCrossRefGoogle Scholar
  5. 5.
    Klintenberg C, Olofsson J, Hellquist H, et al. Adenocarcinoma of the ethmoid sinuses. A review of 28 cases with special reference to wood dust exposure. Cancer 1984;54:482–8.PubMedCrossRefGoogle Scholar
  6. 6.
    Cummins CW, Flint PW, Harker LA, et al. Cummings otolaryngology: Head and Neck Surgery. 4th ed. Philadelphia: Elsevier Mosby; 2004.Google Scholar
  7. 7.
    Citardi MJ, Batra PS. Intraoperative surgical navigation for endoscopic sinus surgery: Rationale and indications. Curr Opin Otolaryngol Head Neck Surg 2007;5:23–7.CrossRefGoogle Scholar
  8. 8.
    Aronsohn MS, Stringer SP, Brown HM. Utility of image guided surgery in the diagnosis of pterygopalatine fossa lesions. Laryngoscope 2004;114:424–7.PubMedCrossRefGoogle Scholar
  9. 9.
    Dulguerov P, Jacobsen MS, Allal AS, et al. Nasal and paranasal sinus carcinoma: Are we making progress? A series of 220 patients and a systematic review. Cancer 2001;92:3012–29.PubMedCrossRefGoogle Scholar
  10. 10.
    Tiwari R, Hardillo JA, Mehta D, et al. Squamous cell carcinoma of maxillary sinus. Head Neck 2000;22:164–9.PubMedCrossRefGoogle Scholar
  11. 11.
    Myers LL, Nussenbaum B, Bradford CR, et al. Paranasal sinus malignancies: An 18-year single institution experience. Laryngoscope 2002;112:1964–9.PubMedCrossRefGoogle Scholar
  12. 12.
    Le QT, Fu KK, Kaplan M, et al. Treatment of maxillary sinus carcinoma: A comparison of the 1997 and 1977 American Joint Committee on cancer staging systems. Cancer 1999;86:1700–11.PubMedCrossRefGoogle Scholar
  13. 13.
    Weber AL, Stanton AC. Malignant tumors of the paranasal sinuses: Radiologic, clinical, and histopathologic evaluation of 200 cases. Head Neck Surg 1984;6:761–76.PubMedCrossRefGoogle Scholar
  14. 14.
    Robin PE, Powell DJ, Stansbie JM. Carcinoma of the nasal cavity and paranasal sinuses: Incidence and presentation of different histological types. Clin Otolaryngol Allied Sci 1979;4:431–56.PubMedCrossRefGoogle Scholar
  15. 15.
    Lawson W, Kaufman MR, Biller HF. Treatment outcomes in the management of inverted papilloma: An analysis of 160 cases. Laryngoscope 2003;113:1548–56.PubMedCrossRefGoogle Scholar
  16. 16.
    Vrabec DP. The inverted Schneiderian papilloma: A 25-year study. Laryngoscope 1994;104:582–605.PubMedCrossRefGoogle Scholar
  17. 17.
    Podd TJ, Dawes PK, Marshall HF. Malignant inverted papillomas: A review of 7 cases and implications for treatment. Clin Oncol (R Coll Radiol) 1994;6:305–7.CrossRefGoogle Scholar
  18. 18.
    Phillips PP, Gustafson RO, Facer GW. The clinical behavior of inverting papilloma of the nose and paranasal sinuses: Report of 112 cases and review of the literature. Laryngoscope 1990;100:463–9.PubMedCrossRefGoogle Scholar
  19. 19.
    Thorp MA, Oyarzabal-Amigo MF, du Plessis JH, et al. Inverted papilloma: A review of 53 cases. Laryngoscope 2001;111:1401–5.PubMedCrossRefGoogle Scholar
  20. 20.
    Hug EB, Wang CC, Montgomery WW, et al. Management of inverted papilloma of the nasal cavity and paranasal sinuses: Importance of radiation therapy. Int J Radiat Oncol Biol Phys 1993;26:67–72.PubMedCrossRefGoogle Scholar
  21. 21.
    Paulino AC, Fisher SG, Marks JE. Is prophylactic neck irradiation indicated in patients with squamous cell carcinoma of the maxillary sinus? Int J Radiat Oncol Biol Phys 1997;39:283–9.PubMedCrossRefGoogle Scholar
  22. 22.
    Yom SS, Rashid A, Rosenthal DI, et al. Genetic analysis of sinonasal adenocarcinoma phenotypes: Distinct alterations of histogenetic significance. Mod Pathol 2005;18:315–9.PubMedCrossRefGoogle Scholar
  23. 23.
    Smith SR, Som P, Fahmy A, et al. A clinicopathological study of sinonasal neuroendocrine carcinoma and sinonasal undifferentiated carcinoma. Laryngoscope 2000;110:1617–22.PubMedCrossRefGoogle Scholar
  24. 24.
    Hsu HC, Chen CL, Hsu MM, et al. Pathology of nasopharyngeal carcinoma. Proposal of a new histologic classification correlated with prognosis. Cancer 1987;59:945–51.PubMedCrossRefGoogle Scholar
  25. 25.
    Zukerberg LR, Rosenberg AE, Randolph G, et al. Solitary fibrous tumor of the nasal cavity and paranasal sinuses. Am J Surg Pathol 1991;15:126–30.PubMedCrossRefGoogle Scholar
  26. 26.
    JG B. Tumors of the head and neck. Williams and Wilkins; 1979.Google Scholar
  27. 27.
    Leon B. Surgical pathology of the head and neck. 2nd ed. New York: Marcel Decker; 2001.Google Scholar
  28. 28.
    Franchi A, Gallo O, Santucci M. Clinical relevance of the histological classification of sinonasal intestinal-type adenocarcinomas. Hum Pathol 1999;30:1140–5.PubMedCrossRefGoogle Scholar
  29. 29.
    Gil Z, Carlson DL, Gupta A, et al. Patterns and incidence of neural invasion in patients with cancers of the paranasal sinuses. Arch Otolaryngol Head Neck Surg 2009;135:173–9.PubMedCrossRefGoogle Scholar
  30. 30.
    Fu YS, Perzin KH. Non-epithelial tumors of the nasal cavity paranasal sinuses, and nasopharynx: A clinicopathologic study. V. Skeletal muscle tumors (rhabdomyoma and rhabdomyosarcoma). Cancer 1976;37:364–76.PubMedCrossRefGoogle Scholar
  31. 31.
    Fu YS, Perzin KH. Non-epithelial tumors of the nasal cavity, paranasal sinuses, and nasopharynx. A clinicopathologic study. VI. Fibrous tissue tumors (fibroma, fibromatosis, fibrosarcoma). Cancer 1976;37:2912–28.PubMedCrossRefGoogle Scholar
  32. 32.
    Levine PA, Frierson HF Jr, Stewart FM, et al. Sinonasal undifferentiated carcinoma: A distinctive and highly aggressive neoplasm. Laryngoscope 1987;97:905–8.PubMedGoogle Scholar
  33. 33.
    Lopategui JR, Gaffey MJ, Frierson HF Jr, et al. Detection of Epstein–Barr viral RNA in sinonasal undifferentiated carcinoma from Western and Asian patients. Am J Surg Pathol 1994;18:391–8.PubMedCrossRefGoogle Scholar
  34. 34.
    Righi PD, Francis F, Aron BS, et al. Sinonasal undifferentiated carcinoma: A 10-year experience. Am J Otolaryngol 1996;17:167–71.PubMedCrossRefGoogle Scholar
  35. 35.
    Helliwell TR, Yeoh LH, Stell PM. Anaplastic carcinoma of the nose and paranasal sinuses. Light microscopy, immunohistochemistry and clinical correlation. Cancer 1986;58:2038–45.PubMedCrossRefGoogle Scholar
  36. 36.
    Gallo O, Graziani P, Fini-Storchi O. Undifferentiated carcinoma of the nose and paranasal sinuses. An immunohistochemical and clinical study. Ear Nose Throat J 1993;72:588–90, 93–5.PubMedGoogle Scholar
  37. 37.
    Phillips CD, Futterer SF, Lipper MH, et al. Sinonasal undifferentiated carcinoma: CT and MR imaging of an uncommon neoplasm of the nasal cavity. Radiology 1997;202:477–80.PubMedCrossRefGoogle Scholar
  38. 38.
    Frierson HF Jr, Mills SE, Fechner RE, et al. Sinonasal undifferentiated carcinoma. An aggressive neoplasm derived from schneiderian epithelium and distinct from olfactory neuroblastoma. Am J Surg Pathol 1986;10:771–9.PubMedCrossRefGoogle Scholar
  39. 39.
    Kraus DH, Dubner S, Harrison LB, et al. Prognostic factors for recurrence and survival in head and neck soft tissue sarcomas. Cancer 1994;74:697–702.PubMedCrossRefGoogle Scholar
  40. 40.
    Landis SH, Murray T, Bolden S, et al. Cancer statistics. CA: A cancer journal for clinicians 1999;49:8–31, 1.Google Scholar
  41. 41.
    Jemal A, Thomas A, Murray T, et al. Cancer statistics. CA: A cancer journal for clinicians 2002;52:23–47.Google Scholar
  42. 42.
    Weber RS, Benjamin RS, Peters LJ, et al. Soft tissue sarcomas of the head and neck in adolescents and adults. Am J Surg 1986;152:386–92.PubMedCrossRefGoogle Scholar
  43. 43.
    Lawrence W Jr, Anderson JR, Gehan EA, et al. Pretreatment TNM staging of childhood rhabdomyosarcoma: A report of the Intergroup Rhabdomyosarcoma Study Group. Children’s Cancer Study Group. Pediatric Oncology Group. Cancer 1997;80:1165–70.PubMedCrossRefGoogle Scholar
  44. 44.
    Lyos AT, Goepfert H, Luna MA, et al. Soft tissue sarcoma of the head and neck in children and adolescents. Cancer 1996;77:193–200.PubMedCrossRefGoogle Scholar
  45. 45.
    Potter BO, Sturgis EM. Sarcomas of the head and neck. Surg Oncol Clin N Am 2003;12:379–417.PubMedCrossRefGoogle Scholar
  46. 46.
    Freedman AM, Reiman HM, Woods JE. Soft-tissue sarcomas of the head and neck. Am J Surg 1989;158:367–72.PubMedCrossRefGoogle Scholar
  47. 47.
    Sturgis EM, Potter BO. Sarcomas of the head and neck region. Curr Opin Oncol 2003;15:239–52.PubMedCrossRefGoogle Scholar
  48. 48.
    Ballo MT, Zagars GK, Cormier JN, et al. Interval between surgery and radiotherapy: Effect on local control of soft tissue sarcoma. Int J Radiat Oncol Biol Phys 2004;58:1461–7.PubMedCrossRefGoogle Scholar
  49. 49.
    Prabhu SS, Diaz E, Sturgis EM, et al. Section on tumors. Mahaley Clinical Research Award. Primary sarcomas of the skull base: An analysis of 63 cases. Clin Neurosurg 2004;51:340–2.PubMedGoogle Scholar
  50. 50.
    Zagars GK, Ballo MT, Pisters PW, et al. Surgical margins and resection in the management of patients with soft tissue sarcoma using conservative surgery and radiation therapy. Cancer 2003;97:2544–53.PubMedCrossRefGoogle Scholar
  51. 51.
    Le Vay J, O’Sullivan B, Catton C, et al. An assessment of prognostic factors in soft-tissue sarcoma of the head and neck. Arch Otolaryngol Head Neck Surg 1994;120:981–6.PubMedCrossRefGoogle Scholar
  52. 52.
    Shah JP, Sundaresan N, Galicich J, et al. Craniofacial resections for tumors involving the base of the skull. Am J Surg 1987;154:352–8.PubMedCrossRefGoogle Scholar
  53. 53.
    O’Sullivan B, Wylie J, Catton C, et al. The local management of soft tissue sarcoma. Semin Radiat Oncol 1999;9:328–48.PubMedCrossRefGoogle Scholar
  54. 54.
    Colville RJ, Charlton F, Kelly CG, et al. Multidisciplinary management of head and neck sarcomas. Head Neck 2005;27:814–24.PubMedCrossRefGoogle Scholar
  55. 55.
    Gil Z, Patel SG, Singh B, et al. Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: An international collaborative study. Cancer 2007;110:1033–41.PubMedCrossRefGoogle Scholar
  56. 56.
    Daou RA, Attia EL, Viloria JB. Malignant fibrous histiocytomas of the head and neck. J Otolaryngol 1983;12:383–8.PubMedGoogle Scholar
  57. 57.
    Barnes L, Kanbour A. Malignant fibrous histiocytoma of the head and neck. A report of 12 cases. Arch Otolaryngol Head Neck Surg 1988;114:1149–56.PubMedCrossRefGoogle Scholar
  58. 58.
    Wood GS, Beckstead JH, Turner RR, et al. Malignant fibrous histiocytoma tumor cells resemble fibroblasts. Am J Surg Pathol 1986;10:323–35.PubMedCrossRefGoogle Scholar
  59. 59.
    Churg AM, Kahn LB. Myofibroblasts and related cells in malignant fibrous and fibrohistiocytic tumors. Hum Pathol 1977;8:205–18.PubMedCrossRefGoogle Scholar
  60. 60.
    Brooks JJ. The significance of double phenotypic patterns and markers in human sarcomas. A new model of mesenchymal differentiation. Am J Pathol 1986;125:113–23.PubMedCentralPubMedGoogle Scholar
  61. 61.
    Gonzalez-Vitale JC, Slavin RE, McQueen JD. Radiation-induced intracranial malignant fibrous histiocytoma. Cancer 1976;37:2960–3.PubMedCrossRefGoogle Scholar
  62. 62.
    Huvos AG, Woodard HQ, Heilweil M. Postradiation malignant fibrous histiocytoma of bone. A clinicopathologic study of 20 patients. Am J Surg Pathol 1986;10:9–18.PubMedCrossRefGoogle Scholar
  63. 63.
    Spector GJ, Ogura JH. Malignant fibrous histiocytoma of the maxilla. A report of an unusual lesion. Arch Otolaryngol 1974;99:385–7.PubMedCrossRefGoogle Scholar
  64. 64.
    Merino MJ, LiVolsi VA. Inflammatory malignant fibrous histiocytoma. Am J Clin Pathol 1980;73:276–81.PubMedGoogle Scholar
  65. 65.
    Kay S. Inflammatory fibrous histiocytoma (? anthogranuloma). Report of two cases with ultrastructural observations in one. Am J Surg Pathol 1978;2:313–9.PubMedCrossRefGoogle Scholar
  66. 66.
    Kyriakos M, Kempson RL. Inflammatory fibrous histiocytoma. An aggressive and lethal lesion. Cancer 1976;37:1584–606.PubMedCrossRefGoogle Scholar
  67. 67.
    Roques AW, Horton LW, Leslie J, et al. Inflammatory fibrous histiocytoma in the left upper abdomen with a leukemoid blood picture. Cancer 1979;43:1800–4.PubMedCrossRefGoogle Scholar
  68. 68.
    Batsakis JG, Rice DH, Howard DR. The pathology of head and neck tumors: Spindle cell lesions (sarcomatoid carcinomas, nodular fasciitis, and fibrosarcoma) of the aerodigestive tracts, Part 14. Head Neck Surg 1982;4:499–513.PubMedCrossRefGoogle Scholar
  69. 69.
    Cavalcanti MG, Ruprecht A, Quets J. Evaluation of maxillofacial fibrosarcoma using computer graphics and spiral computed tomography. Dentomaxillofac Radiol 1999;28:145–51.PubMedCrossRefGoogle Scholar
  70. 70.
    Mark RJ, Bailet JW, Poen J, et al. Postirradiation sarcoma of the head and neck. Cancer 1993;72:887–93.PubMedCrossRefGoogle Scholar
  71. 71.
    Mark RJ, Poen J, Tran LM, et al. Postirradiation sarcomas. A single-institution study and review of the literature. Cancer 1994;73:2653–62.PubMedCrossRefGoogle Scholar
  72. 72.
    Burns WA, Kanhouwa S, Tillman L, et al. Fibrosarcoma occurring at the site of a plastic vascular graft. Cancer 1972;29:66–72.PubMedCrossRefGoogle Scholar
  73. 73.
    Scott SM, Reiman HM, Pritchard DJ, et al. Soft tissue fibrosarcoma. A clinicopathologic study of 132 cases. Cancer 1989;64:925–31.PubMedCrossRefGoogle Scholar
  74. 74.
    Oppenheimer RW, Friedman M. Fibrosarcoma of the maxillary sinus. Ear Nose Throat J 1988;67:193–8.PubMedGoogle Scholar
  75. 75.
    Farhood AI, Hajdu SI, Shiu MH, et al. Soft tissue sarcomas of the head and neck in adults. Am J Surg 1990;160:365–9.PubMedCrossRefGoogle Scholar
  76. 76.
    Heffner DK, Gnepp DR. Sinonasal fibrosarcomas, malignant schwannomas, and “Triton” tumors. A clinicopathologic study of 67 cases. Cancer 1992;70:1089–101.PubMedCrossRefGoogle Scholar
  77. 77.
    Greager JA, Reichard K, Campana JP, et al. Fibrosarcoma of the head and neck. Am J Surg 1994;167:437–9.PubMedCrossRefGoogle Scholar
  78. 78.
    Gardner DG. The peripheral odontogenic fibroma: An attempt at clarification. Oral Surg Oral Med Oral Pathol 1982;54:40–8.PubMedCrossRefGoogle Scholar
  79. 79.
    Kim KI, Yoo SL. Infantile fibrosarcoma in the nasal cavity. Otolaryngol Head Neck Surg 1996;114:98–102.PubMedCrossRefGoogle Scholar
  80. 80.
    Nayar RC, Prudhomme F, Parise O Jr, et al. Rhabdomyosarcoma of the head and neck in adults: A study of 26 patients. Laryngoscope 1993;103:1362–6.PubMedCrossRefGoogle Scholar
  81. 81.
    Lee YY, Van Tassel P, Nauert C, et al. Craniofacial osteosarcomas: Plain film, CT, and MR findings in 46 cases. AJR Am J Roentgenol 1988;150:1397–402.PubMedCrossRefGoogle Scholar
  82. 82.
    Dahlin DC, Coventry MB, Scanlon PW. Ewing’s sarcoma. A critical analysis of 165 cases. J Bone Joint Surg Am 1961;43-A:185–92.PubMedGoogle Scholar
  83. 83.
    Angervall L, Enzinger FM. Extraskeletal neoplasm resembling Ewing’s sarcoma. Cancer 1975;36:240–51.PubMedCrossRefGoogle Scholar
  84. 84.
    Jaffe R, Santamaria M, Yunis EJ, et al. The neuroectodermal tumor of bone. Am J Surg Pathol 1984;8:885–98.PubMedCrossRefGoogle Scholar
  85. 85.
    Dehner LP. Peripheral and central primitive neuroectodermal tumors. A nosologic concept seeking a consensus. Arch Pathol Lab Med 1986;110:997–1005.PubMedGoogle Scholar
  86. 86.
    Dehner LP. Primitive neuroectodermal tumor and Ewing’s sarcoma. Am J Surg Pathol 1993;17:1–13.PubMedCrossRefGoogle Scholar
  87. 87.
    Dehner LP. Neuroepithelioma (primitive neuroectodermal tumor) and Ewing’s sarcoma. At least a partial consensus. Arch Pathol Lab Med 1994;118:606–7.PubMedGoogle Scholar
  88. 88.
    Batsakis JG, Mackay B, el-Naggar AK. Ewing’s sarcoma and peripheral primitive neuroectodermal tumor: An interim report. Ann Otol Rhinol Laryngol 1996;105:838–43.PubMedCrossRefGoogle Scholar
  89. 89.
    Grier HE. The Ewing family of tumors. Ewing’s sarcoma and primitive neuroectodermal tumors. Pediatr Clin North Am 1997;44:991–1004.PubMedCrossRefGoogle Scholar
  90. 90.
    Lee CS, Southey MC, Slater H, et al. Primary cutaneous Ewing’s sarcoma/peripheral primitive neuroectodermal tumors in childhood. A molecular, cytogenetic, and immunohistochemical study. Diagn Mol Pathol 1995;4:174–81.PubMedCrossRefGoogle Scholar
  91. 91.
    Raney RB, Asmar L, Newton WA Jr, et al. Ewing’s sarcoma of soft tissues in childhood: A report from the Intergroup Rhabdomyosarcoma Study, 1972 to 1991. J Clin Oncol 1997;15:574–82.PubMedGoogle Scholar
  92. 92.
    Zelazny A, Remus WR, Wilson AJ. Quantitative analysis of the plain radiographic appearance of Ewing’s sarcoma of bone. Invest Radiol 1997;32:59–65.PubMedCrossRefGoogle Scholar
  93. 93.
    Ibarburen C, Haberman JJ, Zerhouni EA. Peripheral primitive neuroectodermal tumors. CT and MRI evaluation. Eur J Radiol 1996;21:225–32.PubMedCrossRefGoogle Scholar
  94. 94.
    Dunkel IJ, Gerald WL, Rosenfield NS, et al. Outcome of patients with a history of bilateral retinoblastoma treated for a second malignancy: The Memorial Sloan-Kettering experience. Med Pediatr Oncol 1998;30:59–62.PubMedCrossRefGoogle Scholar
  95. 95.
    Klein EA, Anzil AP, Mezzacappa P, et al. Sinonasal primitive neuroectodermal tumor arising in a long-term survivor of heritable unilateral retinoblastoma. Cancer 1992;70:423–31.PubMedCrossRefGoogle Scholar
  96. 96.
    O’Connor TA, McLean P, Juillard GJ, et al. Olfactory neuroblastoma. Cancer 1989; 63:2426–8.PubMedCrossRefGoogle Scholar
  97. 97.
    Dulguerov P, Allal AS, Calcaterra TC. Esthesioneuroblastoma: A meta-analysis and review. Lancet Oncol 2001;2:683–90.PubMedCrossRefGoogle Scholar
  98. 98.
    Rinaldo A, Ferlito A, Shaha AR, et al. Esthesioneuroblastoma and cervical lymph node metastases: Clinical and therapeutic implications. Acta Otolaryngol 2002;122:215–21.PubMedCrossRefGoogle Scholar
  99. 99.
    Lund VJ, Howard D, Wei W, et al. Olfactory neuroblastoma: Past, present, and future? Laryngoscope 2003;113:502–7.PubMedCrossRefGoogle Scholar
  100. 100.
    Lund VJ, Milroy C. Olfactory neuroblastoma: Clinical and pathological aspects. Rhinology 1993;31:1–6.PubMedGoogle Scholar
  101. 101.
    Hirose T, Scheithauer BW, Lopes MB, et al. Olfactory neuroblastoma. An immuno-histochemical, ultrastructural, and flow cytometric study. Cancer 1995;76:4–19.PubMedCrossRefGoogle Scholar
  102. 102.
    Kadish S, Goodman M, Wang CC. Olfactory neuroblastoma. A clinical analysis of 17 cases. Cancer 1976;37:1571–6.PubMedCrossRefGoogle Scholar
  103. 103.
    Kingdom TT, Kaplan MJ. Mucosal melanoma of the nasal cavity and paranasal sinuses. Head Neck 1995;17:184–9.PubMedCrossRefGoogle Scholar
  104. 104.
    Trapp TK, Fu YS, Calcaterra TC. Melanoma of the nasal and paranasal sinus mucosa. Arch Otolaryngol Head Neck Surg 1987;113:1086–9.PubMedCrossRefGoogle Scholar
  105. 105.
    Blatchford SJ, Koopmann CF Jr, Coulthard SW. Mucosal melanoma of the head and neck. Laryngoscope 1986;96:929–34.PubMedCrossRefGoogle Scholar
  106. 106.
    Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: A summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 1998;83:1664–78.PubMedCrossRefGoogle Scholar
  107. 107.
    Holdcraft J, Gallagher JC. Malignant melanomas of the nasal and paranasal sinus mucosa. Ann Otol Rhinol Laryngol 1969;78:5–20.PubMedCrossRefGoogle Scholar
  108. 108.
    Freedman HM, DeSanto LW, Devine KD, et al. Malignant melanoma of the nasal cavity and paranasal sinuses. Arch Otolaryngol 1973;97:322–5.PubMedCrossRefGoogle Scholar
  109. 109.
    Matias C, Corde J, Soares J. Primary malignant melanoma of the nasal cavity: A clinicopathologic study of nine cases. J Surg Oncol 1988;39:29–32.PubMedCrossRefGoogle Scholar
  110. 110.
    Patel SG, Prasad ML, Escrig M, et al. Primary mucosal malignant melanoma of the head and neck. Head Neck 2002;24:247–57.PubMedCrossRefGoogle Scholar
  111. 111.
    Temam S, Mamelle G, Marandas P, et al. Postoperative radiotherapy for primary mucosal melanoma of the head and neck. Cancer 2005;103:313–9.PubMedCrossRefGoogle Scholar
  112. 112.
    Guzzo M, Grandi C, Licitra L, et al. Mucosal malignant melanoma of head and neck: Forty-eight cases treated at Istituto Nazionale Tumori of Milan. Eur J Surg Oncol 1993;19:316–9.PubMedGoogle Scholar
  113. 113.
    Stern SJ, Guillamondegui OM. Mucosal melanoma of the head and neck. Head Neck 1991;13:22–7.PubMedCrossRefGoogle Scholar
  114. 114.
    Yii NW, Eisen T, Nicolson M, et al. Mucosal malignant melanoma of the head and neck: The Marsden experience over half a century. Clin Oncol (R Coll Radiol) 2003;15:199–204.CrossRefGoogle Scholar
  115. 115.
    Manolidis S, Donald PJ. Malignant mucosal melanoma of the head and neck: Review of the literature and report of 14 patients. Cancer 1997;80:1373–86.PubMedCrossRefGoogle Scholar
  116. 116.
    Ravid JM, Esteves JA. Malignant melanoma of the nose and paranasal sinuses and juvenile melanoma of the nose. Arch Otolaryngol 1960;72:431–44.PubMedCrossRefGoogle Scholar
  117. 117.
    Gilligan D, Slevin NJ. Radical radiotherapy for 28 cases of mucosal melanoma in the nasal cavity and sinuses. Br J Radiol 1991;64:1147–50.PubMedCrossRefGoogle Scholar
  118. 118.
    Briggs J, Evans JN. Malignant oxyphilic granular-cell tumor (oncocytoma) of the palate. Review of the recent literature and report of a case. Oral Surg Oral Med Oral Pathol 1967;23:796–802.PubMedCrossRefGoogle Scholar
  119. 119.
    Gorsky M, Epstein JB. Melanoma arising from the mucosal surfaces of the head and neck. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1998;86:715–9.PubMedCrossRefGoogle Scholar
  120. 120.
    Thompson LD, Wieneke JA, Miettinen M. Sinonasal tract and nasopharyngeal melanomas: A clinicopathologic study of 115 cases with a proposed staging system. Am J Surg Pathol 2003;27:594–611.PubMedCrossRefGoogle Scholar
  121. 121.
    Crawford RI, Tron VA, Ma R, et al. Sinonasal malignant melanoma—a clinicopathologic analysis of 18 cases. Melanoma Res 1995;5:261–5.PubMedCrossRefGoogle Scholar
  122. 122.
    Franquemont DW, Mills SE. Sinonasal malignant melanoma. A clinicopathologic and immunohistochemical study of 14 cases. Am J Clin Pathol 1991;96:689–97.PubMedGoogle Scholar
  123. 123.
    Prasad ML, Busam KJ, Patel SG, et al. Clinicopathologic differences in malignant melanoma arising in oral squamous and sinonasal respiratory mucosa of the upper aerodigestive tract. Arch Pathol Lab Med 2003;127:997–1002.PubMedGoogle Scholar
  124. 124.
    Chetty R, Slavin JL, Pitson GA, et al. Melanoma botryoides: A distinctive myxoid pattern of sino-nasal malignant melanoma. Histopathology 1994;24:377–9.PubMedCrossRefGoogle Scholar
  125. 125.
    Prasad ML, Patel SG, Busam KJ. Primary mucosal desmoplastic melanoma of the head and neck. Head Neck 2004;26:373–7.PubMedCrossRefGoogle Scholar
  126. 126.
    Batsakis JG, Regezi JA, Solomon AR, et al. The pathology of head and neck tumors: Mucosal melanomas, part 13. Head Neck Surg 1982;4:404–18.PubMedCrossRefGoogle Scholar
  127. 127.
    Kilpatrick SE, White WL, Browne JD. Desmoplastic malignant melanoma of the oral mucosa. An underrecognized diagnostic pitfall. Cancer 1996;78:383–9.PubMedCrossRefGoogle Scholar
  128. 128.
    Brandwein MS, Rothstein A, Lawson W, et al. Sinonasal melanoma. A clinicopathologic study of 25 cases and literature meta-analysis. Arch Otolaryngol Head Neck Surg 1997;123:290–6.PubMedCrossRefGoogle Scholar
  129. 129.
    Briele HA, Walker MJ, Das Gupta TK. Melanoma of the head and neck. Clin Plast Surg 1985;12:495–504.PubMedGoogle Scholar
  130. 130.
    Conley J, Pack GT. Melanoma of the mucous membranes of the head and neck. Arch Otolaryngol 1974;99:315–9.PubMedCrossRefGoogle Scholar
  131. 131.
    Lentsch EJ, Myers JN. Melanoma of the head and neck: Current concepts in diagnosis and management. Laryngoscope 2001;111:1209–22.PubMedCrossRefGoogle Scholar
  132. 132.
    Ganly I, Patel SG, Singh B, et al. Craniofacial resection for malignant melanoma of the skull base: Report of an international collaborative study. Arch Otolaryngol Head Neck Surg 2006;132:73–8.PubMedCrossRefGoogle Scholar
  133. 133.
    McMaster MJ, Soule EH, Ivins JC. Hemangiopericytoma. A clinicopathologic study and long-term followup of 60 patients. Cancer 1975;36:2232–44.PubMedCrossRefGoogle Scholar
  134. 134.
    Nielsen GP, Dickersin GR, Provenzal JM, et al. Lipomatous hemangiopericytoma. A histologic, ultrastructural and immunohistochemical study of a unique variant of hemangiopericytoma. Am J Surg Pathol 1995;19:748–56.PubMedCrossRefGoogle Scholar
  135. 135.
    Eichhorn JH, Dickersin GR, Bhan AK, et al. Sinonasal hemangioperi-cytoma. A reassessment with electron microscopy, immunohistochemistry, and long-term follow-up. Am J Surg Pathol 1990;14:856–66.PubMedCrossRefGoogle Scholar
  136. 136.
    Chan JK, Ng CS, Lau WH, et al. Most nasal/nasopharyngeal lymphomas are peripheral T-cell neoplasms. Am J Surg Pathol 1987;11:418–29.PubMedCrossRefGoogle Scholar
  137. 137.
    Tomita Y, Ohsawa M, Mishiro Y, et al. The presence and subtype of Epstein–Barr virus in B and T-cell lymphomas of the sino-nasal region from the Osaka and Okinawa districts of Japan. Lab Invest 1995;73:190–6.PubMedGoogle Scholar
  138. 138.
    Abbondanzo SL, Wenig BM. Non-Hodgkin’s lymphoma of the sinonasal tract. A clinicopathologic and immunophenotypic study of 120 cases. Cancer 1995;75:1281–91.PubMedCrossRefGoogle Scholar
  139. 139.
    Rog RP. Beware of malignant lymphoma masquerading as facial inflammatory processes. Oral Surg Oral Med Oral Pathol 1991;71:415–9.PubMedCrossRefGoogle Scholar
  140. 140.
    Ferry JA, Sklar J, Zukerberg LR, et al. Nasal lymphoma. A clinicopathologic study with immunophenotypic and genotypic analysis. Am J Surg Pathol 1991;15:268–79.PubMedCrossRefGoogle Scholar
  141. 141.
    Ratech H, Burke JS, Blayney DW, et al. A clinicopathologic study of malignant lymphomas of the nose, paranasal sinuses, and hard palate, including cases of lethal midline granuloma. Cancer 1989;64:2525–31.PubMedCrossRefGoogle Scholar
  142. 142.
    Cheung MM, Chan JK, Lau WH, et al. Primary non-Hodgkin’s lymphoma of the nose and nasopharynx: Clinical features, tumor immunophenotype, and treatment outcome in 113 patients. J Clin Oncol 1998;16:70–7.PubMedGoogle Scholar
  143. 143.
    Nakamura K, Uehara S, Omagari J, et al. Primary non-Hodgkin lymphoma of the sinonasal cavities: Correlation of CT evaluation with clinical outcome. Radiology 1997;204:431–5.PubMedCrossRefGoogle Scholar
  144. 144.
    Wollner N, Mandell L, Filippa D, et al. Primary nasal-paranasal oropharyngeal lymphoma in the pediatric age group. Cancer 1990;65:1438–44.PubMedCrossRefGoogle Scholar
  145. 145.
    Sabo R, Sela M, Sabo G, et al. Metastatic hypernephroma to the head and neck: Unusual case reports and review of the literature. J Otolaryngol 2001;30:140–4.PubMedCrossRefGoogle Scholar
  146. 146.
    Nahum AM, Bailey BJ. Malignant tumors metastatic to the paranasal sinuses: Case report and review of the literature. Laryngoscope 1963;73:942–53.PubMedCrossRefGoogle Scholar
  147. 147.
    Prescher A, Brors D. Sarcomas of the head and neck. Surg Oncol Clin N Am 2003;12:583–94.Google Scholar
  148. 148.
    Prescher A, Brors D. Metastases to the paranasal sinuses: Case report and review of the literature. Laryngorhinootologie 2001;80:583–94.PubMedCrossRefGoogle Scholar
  149. 149.
    Stern SJ, Goepfert H, Clayman G, et al. Squamous cell carcinoma of the maxillary sinus. Arch Otolaryngol Head Neck Surg 1993;119:964–9.PubMedCrossRefGoogle Scholar

Copyright information

© The Author(s)  2012

Authors and Affiliations

  • Oshri Wasserzug
    • 1
  • Leonor Leider-Trejo
    • 2
  • Dan M. Fliss
    • 1
  • Ziv Gil
    • 3
  1. 1.Department of Otolaryngology, Head and Neck and Maxillofacial SurgeryTel Aviv Sourasky Medical Center, Tel Aviv UniversityTel AvivIsrael
  2. 2.Institute of PathologyTel Aviv Sourasky Medical Center, Tel Aviv UniversityTel AvivIsrael
  3. 3.Head and Neck Surgery Unit, Department of Otolaryngology, Head and Neck and Maxillofacial SurgeryTel Aviv Sourasky Medical Center, Tel Aviv UniversityTel AvivIsrael

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