Skull Base Surgery in the Twenty-First Century
Part of the
Head and Neck Cancer Clinics
book series (HNCC)
Skull base tumours (SBTs) include a variety of neoplasms that originate in the paranasal sinuses, skull base, meninges or brain. These tumours can be of bone or soft tissue origin. The incidence of these tumours varies according to demographical and geographical factors, as well as exposure to different carcinogens. Tumours originating at different sites also differ in their pathophysiology, biological behaviour, and sensitivity to radiotherapy (RT) and chemotherapy. All these factors play an important role in tailoring treatment in this population. Standardization of staging paradigms has allowed uniformity in categorizing tumour status and histology, enabling common guidelines to be established for evaluating and treating skull base cancers.
KeywordsSkull Base Paranasal Sinus Anterior Skull Base Skull Base Surgery Skull Base Tumour
Ketcham AS, Wilkins RH, Vanburen JM, et al.
A combined intracranial facial approach to the paranasal sinuses. Am J Surg
Van Buren JM, Ommaya AK, Ketcham AS. Ten years’ experience with radical combined craniofacial resection of malignant tumors of the paranasal sinuses. J Neurosurg
Gil Z, Patel SG, Singh B, et al.
Analysis of prognostic factors in 146 patients with anterior skull base sarcoma: An international collaborative study. Cancer
Shah JP, Galicich JH. Craniofacial resection for malignant tumors of ethmoid and anterior skull base. Arch Otolaryngol
Fliss DM, Abergel A, Cavel O, et al.
Combined subcranial approaches for excision of complex anterior skull base tumors. Arch Otolaryngol Head Neck Surg
Patel SG, Singh B, Polluri A, et al.
Craniofacial surgery for malignant skull base tumors: Report of an international collaborative study. Cancer
Gil Z, Patel SG, Bilsky M, et al.
Complications after craniofacial resection for malignant tumors: Are complication trends changing? Otolaryngol Head Neck Surg
Jemal A, Siegel R, Xu J, et al.
Cancer Statistics, 2010. CA Cancer J Clin
Bilsky MH, Bentz B, Vitaz T, et al.
Craniofacial resection for cranial base malignancies involving the infratemporal fossa. Neurosurgery
:339–47; discussion 339–47.PubMedCentralCrossRefPubMedGoogle Scholar
Snyderman C, Carrau R, Kassam A. Who is the skull base surgeon of the future? Skull Base
Hanna E, DeMonte F, Ibrahim S, et al.
Endoscopic resection of sinonasal cancers with and without craniotomy: Oncologic results. Arch Otolaryngol Head Neck Surg
Mehta RP, Cueva RA, Brown JD, et al.
What’s new in skull base medicine and surgery? Skull Base Committee Report. Otolaryngol Head Neck Surg