Boerhaavia diffusa-Derived Antiviral Glycoprotein: A Novel, Eco-friendly Approach for the Management of Viral Diseases


Many higher plants are known to contain endogenous proteins that act as virus inhibitors (Hansen 1989; Chessin et al. 1995 and Verma et al. 1998). All these belong to a class of proteins called ribosome-inactivating proteins (RIPs). These proteins have been studied in Phytolacca americana (Irvin 1975), Mirabilis jalapa (Kubo et al. 1990), and Trichosanthes kirilowii (Yeung et al. 1988) and show antiviral activity when mixed with virus inoculum (Loebenstein 1972; Kumar et al. 1997). On the other hand, some virus inhibitors of plant origin have been reported to induce systemic resistance in non-treated parts of plants also and thereby preventing infection of viruses (Verma et al. 1979; Ponz and Broening 1986; Verma et al. 1995, 1996, 1998). One such glycoproteinaceous substance isolated from B. diffusa roots has prevented virus infection and multiplication in plants (Verma and Awasthi 1979: Verma et al. 1979). It has shown very high antiviral activity when mixed with viruses in vitro and provoked the plant system to produce new protein(s) in the treated plants which is the actual virus inhibitory agent (VIA) (Verma and Awasthi 1980). This glycoprotein induces antiviral state in the plants, through formation of a de novo synthesized protein, and perhaps is active in signaling the activation of defense mechanism in susceptible hosts.


Antiviral Agent Ursolic Acid Root Extract Bottle Gourd Antiviral State 


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© Springer India 2015

Authors and Affiliations

  1. 1.Department of Plant PathologyN.D. University of Agriculture and TechnologyFaizabadIndia
  2. 2.Jaipur National UniversityJaipurIndia

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