Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

  • D. Archana
  • Pradip Kumar Dutta
  • Joydeep DuttaEmail author
Part of the Springer Series on Polymer and Composite Materials book series (SSPCM)


A wide variety of polymers have been used over decades for the preparation of dressing materials for wound healing applications. But the dressing materials based on polysaccharides such as chitosan (CS) have received tremendous attention of the worldwide researchers as a consequence of its important properties like anti-infectional activity, biocompatibility, biodegradability, nontoxicity to mention a few. CS helps in every phase of wound healing such as acting as barrier against microbes, absorbing exudates, accelerates the infiltration of inflammatory cells like neutrophils and helps in healing without scar formation. A reason behind the popularity of CS is that not only it can easily be processed as gels, films, fibers, and scaffolds but also can be blended with natural as well as synthetic polymers to reduce price and improve properties like mechanical, wettability, gas permeability, and handling. Apart from natural and synthetic polymers, CS is also blended with nanoparticles and growth factors to which it shows better antibacterial activity and reduce time span for wound healing. The present chapter aims to focus on feasibility of combining natural polymers, synthetic polymers, nanoparticles, and growth factors with CS for the preparation of wound dressings as basic healthcare materials for regenerative medicine.


Chitosan Synthetic polymers Natural polymers Nanoparticles Growth factors Wound healing applications 



Bacterial cellulose


Bacterial cellulose–chitosan


Bilayer dermal equivalent


Carboxymethylated chitosan




Chitosan lactate


Degree of acetylation


Degree of deacetylation


Epidermal growth factor


Ethylcarbodiimide hydrochloride


Ethylenediamine tetraacetic acid


Extracellular matrix


Fibroblast growth factor


Induces matrix metalloproteinase


Molecular weight


Oxidation of carboxymethyl cellulose


Platelet-derived growth factor


Poly(L-glutamic acid)


Poly(ethylene oxide)


Poly(vinyl alcohol)


Poly(vinyl pyrrolidone)


Polyelectrolyte complex


Recombinant human granulocyte-macrophage colony-stimulating factor


Silver nanoparticles


Titanium dioxide

β (TGF-β).

Transforming growth factor


Vascular endothelial growth factor



One of the authors (DA) gratefully acknowledged the full cooperation as obtained from MNNIT Allahabad during her post doctoral research work.


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Copyright information

© Springer India 2016

Authors and Affiliations

  • D. Archana
    • 1
  • Pradip Kumar Dutta
    • 1
    • 2
  • Joydeep Dutta
    • 3
    Email author
  1. 1.Department of ChemistryMN National Institute of TechnologyAllahabadIndia
  2. 2.Centre for Medical Diagnostics and ResearchMN National Institute of TechnologyAllahabadIndia
  3. 3.Department of Chemistry, Amity School of Applied SciencesAmity University HaryanaManesarIndia

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