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Chitosan: A Potential Therapeutic Dressing Material for Wound Healing

  • D. Archana
  • Pradip Kumar Dutta
  • Joydeep DuttaEmail author
Chapter
Part of the Springer Series on Polymer and Composite Materials book series (SSPCM)

Abstract

A wide variety of polymers have been used over decades for the preparation of dressing materials for wound healing applications. But the dressing materials based on polysaccharides such as chitosan (CS) have received tremendous attention of the worldwide researchers as a consequence of its important properties like anti-infectional activity, biocompatibility, biodegradability, nontoxicity to mention a few. CS helps in every phase of wound healing such as acting as barrier against microbes, absorbing exudates, accelerates the infiltration of inflammatory cells like neutrophils and helps in healing without scar formation. A reason behind the popularity of CS is that not only it can easily be processed as gels, films, fibers, and scaffolds but also can be blended with natural as well as synthetic polymers to reduce price and improve properties like mechanical, wettability, gas permeability, and handling. Apart from natural and synthetic polymers, CS is also blended with nanoparticles and growth factors to which it shows better antibacterial activity and reduce time span for wound healing. The present chapter aims to focus on feasibility of combining natural polymers, synthetic polymers, nanoparticles, and growth factors with CS for the preparation of wound dressings as basic healthcare materials for regenerative medicine.

Keywords

Chitosan Synthetic polymers Natural polymers Nanoparticles Growth factors Wound healing applications 

Abbreviations

BC

Bacterial cellulose

BC–Ch

Bacterial cellulose–chitosan

BDE

Bilayer dermal equivalent

CMCS

Carboxymethylated chitosan

CS

Chitosan

ChL

Chitosan lactate

DA

Degree of acetylation

DD

Degree of deacetylation

EGF

Epidermal growth factor

EDC

Ethylcarbodiimide hydrochloride

EDTA

Ethylenediamine tetraacetic acid

ECM

Extracellular matrix

FGF

Fibroblast growth factor

MMP

Induces matrix metalloproteinase

Mw

Molecular weight

OCMC

Oxidation of carboxymethyl cellulose

PDGF

Platelet-derived growth factor

PGA

Poly(L-glutamic acid)

PEO

Poly(ethylene oxide)

PVA

Poly(vinyl alcohol)

PVP

Poly(vinyl pyrrolidone)

PEC

Polyelectrolyte complex

rhGM-CSF

Recombinant human granulocyte-macrophage colony-stimulating factor

AgNPs

Silver nanoparticles

TiO2

Titanium dioxide

β (TGF-β).

Transforming growth factor

VEGF

Vascular endothelial growth factor

Notes

Acknowledgments

One of the authors (DA) gratefully acknowledged the full cooperation as obtained from MNNIT Allahabad during her post doctoral research work.

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Copyright information

© Springer India 2016

Authors and Affiliations

  • D. Archana
    • 1
  • Pradip Kumar Dutta
    • 1
    • 2
  • Joydeep Dutta
    • 3
    Email author
  1. 1.Department of ChemistryMN National Institute of TechnologyAllahabadIndia
  2. 2.Centre for Medical Diagnostics and ResearchMN National Institute of TechnologyAllahabadIndia
  3. 3.Department of Chemistry, Amity School of Applied SciencesAmity University HaryanaManesarIndia

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