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Prospects of Bioactive Chitosan-Based Scaffolds in Tissue Engineering and Regenerative Medicine

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Chitin and Chitosan for Regenerative Medicine

Part of the book series: Springer Series on Polymer and Composite Materials ((SSPCM))

Abstract

Chitosan, a natural-based polymer obtained by alkaline deacetylation of chitin, is non-toxic, biocompatible, and biodegradable. Due to its desired properties, chitosan-based materials are widely considered to fabricate scaffolds for tissue engineering and regenerative medicine. These scaffolds provide characteristic advantages, such as preservation of cellular phenotype, binding and enhancement of bioactive factors, control of gene expression, and synthesis and deposition of tissue-specific extracellular matrix (ECM), to tissue regeneration. Therefore, the scaffolds based on chitosan and its composites have potential to be used in bone, cartilage, liver, nerve, and musculoskeletal tissue engineering.

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Acknowledgments

The authors thank DST-Nano Mission, Department of Science and Technology, Government of India for their financial support.

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Authors and Affiliations

  1. Department of Chemistry, Hindustan Institute of Technology and Science, Padur, Chennai, 603 103, India

    M. Prabaharan & P. R. Sivashankari

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  1. M. Prabaharan
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  2. P. R. Sivashankari
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Correspondence to M. Prabaharan .

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Editors and Affiliations

  1. Chemistry, MN National Institute of Technology, Allahabad, Uttar Pradesh, India

    Pradip Kumar Dutta

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Prabaharan, M., Sivashankari, P.R. (2016). Prospects of Bioactive Chitosan-Based Scaffolds in Tissue Engineering and Regenerative Medicine. In: Dutta, P. (eds) Chitin and Chitosan for Regenerative Medicine. Springer Series on Polymer and Composite Materials. Springer, New Delhi. https://doi.org/10.1007/978-81-322-2511-9_2

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