Managing Perineural and Skull Base Involvement

Part of the Head and Neck Cancer Clinics book series (HNCC)


Australia is recognized as the non-melanoma skin cancer (NMSC) capital of the world with approximately 300,000 cases diagnosed annually [1]. NMSC with perineural invasion (PNI) is an aggressive feature, which carries a worse prognosis through higher rates of locoregional recurrence and reduced survival [2–5]. NMSC with PNI has been shown to be associated with a disease-specific survival at 3 years of 64 %, compared to NMSC without PNI of 91 % [6].


Facial Nerve Skull Base Postoperative Radiotherapy Trigeminal Neuralgia Perineural Invasion 



The authors wish to thank Dr Mitesh Gandhi for his input regarding radiological assessment and diagnosis.


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Copyright information

© Faruque Riffat, Carsten E. Palme, Michael Veness, Rehan Kazi, Raghav C. Dwivedi 2015

Authors and Affiliations

  1. 1.Department of Otolaryngology-Head and Neck Surgery, School of MedicineUniversity of Queensland, Princess Alexandra Hospital, QIMR Berghofer Institute of Medical ResearchBrisbaneAustralia
  2. 2.Department of Otolaryngology-Head and Neck Surgery, School of MedicineUniversity of Queensland, Queensland Head and Neck Cancer Centre, Queensland Skull Base Unit, Princess Alexandra HospitalBrisbaneAustralia

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